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4-phenylenediamine (p-phenylenediamine)

Subscribe to New Research on 4-phenylenediamine

agent hair dye responsible for contact dermatitis; RN given refers to parent cpd

Also Known As:

p-phenylenediamine; para-phenylenediamine; 1,4-benzenediamine; 1,4-phenyldiamine; 1,4-phenylenediamine; 4-phenylenediamine bromide, ion(1+); 4-phenylenediamine dihydrochloride; 4-phenylenediamine diperchlorate; 4-phenylenediamine ion (1+); 4-phenylenediamine monohydrobromide; 4-phenylenediamine monohydrochloride; 4-phenylenediamine monohydroiodide; 4-phenylenediamine monooxalate; 4-phenylenediamine monoperchlorate; 4-phenylenediamine monosulfate; 4-phenylenediamine sulfate; Ursol-D; paraphenylenediamine

Networked: 283 relevant articles (1 outcomes, 11 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Amines: 1422
  - Polyamines: 1386
    - Diamines: 43
      - Phenylenediamines: 2
        4-phenylenediamine: 283
  - Aniline Compounds: 3
    - Phenylenediamines: 2
      - 4-phenylenediamine: 283

Experts

1.	Naisbitt, Dean J: 7 articles (10/2015 - 02/2007)
2.	Johansen, Jeanne D: 5 articles (04/2014 - 03/2011)
3.	Menné, Torkil: 5 articles (07/2013 - 06/2005)
4.	McFadden, J P: 5 articles (12/2007 - 08/2002)
5.	Bruze, Magnus: 4 articles (07/2015 - 02/2013)
6.	Park, B Kevin: 4 articles (08/2014 - 02/2007)
7.	Jenkinson, Claire: 4 articles (03/2010 - 04/2008)
8.	Krecisz, Beata: 4 articles (01/2009 - 01/2007)
9.	Basketter, D A: 4 articles (12/2007 - 08/2002)
10.	Pirmohamed, Munir: 3 articles (10/2015 - 04/2008)

Related Diseases

1.	Necrosis 04/15/1992 - "Muscle mitochondria were found to be particularly effective in promoting p-phenylenediamine oxidation in vitro and the magnitude of the mitochondrial effects of the various compounds tested correlated well with their ability to cause muscle necrosis in vivo. " 08/01/1989 - "In the present study, the autoxidation rates of p-phenylenediamine and its N-methyl, dimethyl, trimethyl and tetramethyl derivatives have been determined and compared with the severity of the muscle necrosis induced by each of these compounds in rats. " 04/15/1992 - "A number of p-phenylenediamine derivatives are known to cause necrosis of skeletal and/or cardiac muscle when administered to experimental animals. " 10/01/1983 - "Paraphenylenediamine induced acute tubular necrosis following hair dye ingestion." 05/01/1977 - "The process of degeneration, necrosis and regeneration of skeletal muscle fibers of rats administered dimethyl-para-phenylenediamine was studied by light and electron microscopy. "
2.	Hypersensitivity (Allergy) 07/01/2015 - "Contact allergy to TDM was found in 3.6% (1.3-18.2) Simultaneous reactivity to p-phenylenediamine was found in 61.1% of the TDM-positive patients. " 04/01/2015 - "Analysis of the Results from the Patch Test to Para-Phenylenediamine in the TRUE Test in Patients with a Hair Dye Contact Allergy." 02/01/2014 - "Introduction of a methoxymethyl side chain into p-phenylenediamine attenuates its sensitizing potency and reduces the risk of allergy induction." 06/01/2013 - "Para-phenylenediamine is a substance with high allergenicity potential and may cause serious allergic reactions. " 02/01/2013 - "This could possibly be explained by the fact that the prevalence of p-phenylenediamine allergy was higher in the Belgian population. "
3.	Poisoning 01/01/1962 - "[Experimental studies of orthophenylenediamine, metaphenylenediamine and paraphenylenediamine hydrochloride poisoning]." 09/01/2015 - "Paraphenylenediamine poisoning is among one of the emerging causes of poisoning in Asian countries, because it is a constituent of hair dye formulations and is easily available in market at low cost. " 09/01/2015 - "Paraphenylenediamine Containing Hair Dye: An Emerging Household Poisoning." 04/01/2013 - "Paraphenylenediamine poisoning." 03/01/2013 - "Hair dye poisoning [paraphenylenediamine, Super vasamol 33]."
4.	Contact Dermatitis (Eczema, Contact) 01/01/2014 - "Clues to diagnosis of connubial contact dermatitis to paraphenylenediamine." 08/01/2012 - "Contact dermatitis to para-phenylenediamine in hair dye following sensitization to black henna tattoos - an ongoing problem." 07/01/2011 - "Epidemiological trends in contact dermatitis to hair dye: Comparing para-phenylenediamine positivity after a decade long interval." 04/01/2011 - "Late reactions to patch test preparations with reduced concentrations of p-phenylenediamine: a multicentre investigation of the German Contact Dermatitis Research Group." 05/01/2009 - "Para-phenylenediamine, which is sometimes added to obtain a dark, blackish henna, causes the majority of contact dermatitis reported related with tattoos. "
5.	Rhabdomyolysis 06/01/1995 - "Rhabdomyolysis in paraphenylenediamine intoxication." 12/01/1990 - "[Rhabdomyolysis due to paraphenylenediamine (hair dye)--report of an autopsy case]." 08/27/1983 - "Rhabdomyolysis in para-phenylenediamine intoxication." 09/01/1989 - "3. Paraphenylenediamine may cause rhabdomyolysis resulting in acute renal failure in humans. " 09/01/1989 - "1. We present a 40-year-old healthy man who developed a typical clinical picture of rhabdomyolysis following the administration of paraphenylenediamine by a witchdoctor as a pain killer. "

Related Drugs and Biologics

1.	Tuberculin (PPD)
2.	Coloring Agents (Dyes)
3.	Nickel
4.	4-(2'-pyridyldithio)benzyldiazoacetate (PPDA)
5.	Cobalt
6.	Bandrowski's base
7.	4-nitroaniline
8.	Hair Dyes
9.	Allergens
10.	Formaldehyde (Formol)

Related Therapies and Procedures

1.	Skin Care
2.	Tattooing
3.	Lasers (Laser)
4.	Electrodes (Electrode)