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Contact Dermatitis (Eczema, Contact)

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A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.

Also Known As:

Eczema, Contact; Dermatitis, Contact; Contact Dermatitides; Contact Eczema; Contact Hypersensitivities; Contact Hypersensitivity; Contact Sensitivities; Contact Sensitivity; Dermatitides, Contact; Hypersensitivities, Contact; Sensitivities, Contact; Dermatitis Venenata; Hypersensitivity, Contact; Sensitivity, Contact

Networked: 5268 relevant articles (94 outcomes, 370 trials/studies)

Relationship Network

Disease Context: Research Results

Skin and Connective Tissue Diseases
- Skin Diseases: 8226
  - Dermatitis: 5730
    - Contact Dermatitis: 5268
  - Eczematous Skin Diseases: 17
    - Contact Dermatitis: 5268

Related Diseases

1.	Hypersensitivity (Allergy)
2.	Atopic Dermatitis (Atopic Eczema)
3.	Eczema
4.	Rhinitis
5.	Edema

Experts

1.	Szczepanik, Marian: 37 articles (10/2015 - 05/2002)
2.	Maibach, Howard I: 34 articles (11/2015 - 02/2002)
3.	Fowler, Joseph F: 29 articles (11/2015 - 02/2002)
4.	Sasseville, Denis: 28 articles (11/2015 - 03/2006)
5.	Storrs, Frances J: 27 articles (09/2013 - 02/2002)
6.	Belsito, Donald V: 26 articles (11/2015 - 02/2002)
7.	Taylor, James S: 25 articles (11/2015 - 12/2002)
8.	Marks, James G: 25 articles (11/2015 - 03/2002)
9.	Warshaw, Erin M: 25 articles (11/2015 - 09/2004)
10.	Zug, Kathryn A: 22 articles (11/2015 - 06/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Contact Dermatitis:

1.	Dinitrochlorobenzene (DNCB)IBA 06/11/2014 - "This study investigated the anti-inflammatory effects of externally applied Kochia scoparia water extract (KSW) in 2,4-dinitrochlorobenzene (DNCB)-induced contact dermatitis mouse model. " 10/01/2013 - "The aim of this study is to explore the impact of the sensitization on contact hypersensitivity to dinitrochlorobenzene (DNCB) in rats by measuring the incidence and intensity of a challenge response in hosts sensitized with two different doses (i.e. " 06/01/2011 - "The study revealed that OWV has anti-inflammatory and anti-proliferative effects in a DNCB-induced contact dermatitis mice model. " 01/01/1999 - "In the present study, CD4+ cell and gammadelta T-cell populations were of similar size in the normal and DNCB-treated lambs, suggesting an equal participation in the elicitation phase of contact hypersensitivity." 06/01/1993 - "Ultrastructural studies bearing on the mechanism of UVB-impaired induction of contact hypersensitivity to DNCB in man."
2.	Sunscreening Agents (Sunscreens)IBA 03/01/1993 - "All three sunscreens gave complete protection against local suppression of contact hypersensitivity caused by a dose of 2 kJ/m2 UVB. " 04/01/2000 - "Both sunscreens protected against suppression of contact hypersensitivity but the product with the higher ultraviolet A-protection factor showed significantly greater protection. " 01/01/2002 - "Protection against UV-induced suppression of contact hypersensitivity responses by sunscreens in humans." 11/01/1997 - "Several studies in mice of the protection afforded by sunscreens from UVB-induced suppression of contact hypersensitivity have yielded conflicting reports ranging from complete protection to no protection. " 10/01/1995 - "To date, studies of the effectiveness of sunscreens in preventing UVB-induced suppression of contact hypersensitivity in humans have not been published. "
3.	AntigensIBA 06/01/2012 - "Percutaneous immune responses were evaluated through irritant- and hapten-induced contact hypersensitivity studies and by measuring humoral responses to epicutaneous sensitization with protein antigen. " 05/01/2012 - "Extensive studies of contact sensitivity reactions in mice established a mechanistic paradigm that has been revisited in recent years, and the involvement of Langerhans cells (LCs), a population of epidermal dendritic cells, in immune responses to epicutaneously applied antigens has been questioned. " 03/01/1994 - "In this study, 2,4-dinitro-1-fluorobenzene contact sensitivity responses in BALB/c and C3H/He mice demonstrated the importance of early-acting and antigen-specific contact sensitivity-initiating cells to recruit the classical, late-acting contact sensitivity effector T cells. " 09/01/2015 - "Hapten-induced contact hypersensitivity responses were more sustained in LC-specific CTCF-deficient mice, whereas epicutaneous sensitization to protein antigen was attenuated, indicating that CTCF-dependent LC homeostasis is required for optimal immune function of LCs in a context-dependent manner. " 09/01/2015 - "Murine contact sensitivity (CS) reaction could be antigen-specifically regulated by T CD8(+) suppressor (Ts) lymphocytes releasing microRNA-150 in antibody light-chain-coated exosomes that were formerly suggested to suppress CS through action on macrophages (Mφ). "
4.	Adrenal Cortex Hormones (Corticosteroids)IBA 03/01/1992 - "We found corticosteroids to be the 7th most frequent allergen, positive results being obtained in 2.9% of all patients referred to our contact dermatitis unit. " 11/01/2001 - "Efficacy of corticosteroids in acute experimental irritant contact dermatitis?" 03/01/2000 - "The concentrations chosen for the corticosteroids were the same as those used in a study within the European Environmental Contact Dermatitis Research Group (EECDRG), in which 2 corticosteroid mixes (1 with a high concentration and 1 with a low concentration) and the 3 individual constituents, each at 2 concentrations, were patch tested. " 07/01/1997 - "Further studies are needed to assess whether treatment with topical corticosteroids is an effective modality in skin irritation and irritant contact dermatitis." 12/01/2012 - "The reactions observed seem to be in most cases 'systemic contact dermatitis' due to oral or parenteral re-exposure of sensitized individuals with the respective corticosteroids previously applied topically. "
5.	AllergensIBA 03/01/2008 - "The patient's condition cleared after discontinuation of all topical products containing PG and her other identified allergens, but she noted flares of her contact dermatitis following the ingestion of foods containing PG. " 07/01/2015 - "The study was conducted to assess the performance of the Chemotechnique plant series (PL-1000), consisting of 14 allergens, in patients with clinically suspected occupational contact dermatitis to plant allergens. " 05/01/2015 - "The aims of this study were to determine the clinical pattern patch-testing profile of contact dermatitis in saffron workers and to identify the most common allergens/sensitizers. " 03/01/2014 - "This study demonstrates the results of patch testing performed between 2000 and 2009 at the contact dermatitis clinic, Siriraj Hospital, Bangkok and risk factors for the top 5 common allergens. " 01/01/2014 - "This study has two purposes:--to know whether the European standard series is still the key reference when it comes to contact dermatitis, i.e., are its components still the most frequently involved allergens in contact dermatitis nowadays?--to assess the results of the European standard series among French and Belgian dermatologists/allergists as, so far, most of them have failed to provide statistical data within the European community of allergists/dermatologists. "
6.	DinitrofluorobenzeneIBA 06/01/2013 - "In the present study, we used 1-fluoro-2,4- dinitrofluorobenzene (DNFB)-induced contact dermatitis (CD) mouse model to investigate the antiallergic and the anti-inflammatory effects of URC on skin lesion, histopathological changes and specific antibody production. " 06/26/2012 - "The present study investigated the anti-allergic and anti-inflammatory effects of SR using 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis mouse model and in vitro using RBL-2H3 cells. " 06/01/2012 - "In the present study, we investigate anti-allergic and anti-inflammatory effects of LR by using the 1-fluoro-2, 4- dinitrofluorobenzene (DNFB)-induced contact dermatitis mouse model. " 01/15/2010 - "In this study, we have examined its role in local skin inflammatory reactions during development of contact hypersensitivity toward a hapten 2,4-dinitrofluorobenzene (DNFB). " 04/15/2008 - "The objective of the study was to determine the cellular and cytokine responses associated with dinitrofluorobenzene (DNFB)-induced skin contact hypersensitivity (SCH), as an indicator of cell-mediated immune response, in the chicken. "
7.	NickelIBA 12/01/2000 - "We review controlled trials of corticosteroid effect in experimentally elicited acute nickel contact dermatitis in man, in the hope of clarifying optimal efficacy for clinical use. " 03/01/2013 - "Therefore, a nutritional study was performed to assess the effect on UVR suppression of cutaneous cell-mediated immunity (CMI) reflected by nickel contact hypersensitivity (CHS). " 09/01/2010 - "Nickel is the most common sensitizer in almost all studies pertaining to pediatric contact dermatitis. " 02/01/2006 - "The aim of this meta-analysis study on former nickel-exposure investigations was to provide the best possible estimation of threshold values of nickel doses that may cause systemic contact dermatitis in nickel-sensitive patients. " 01/01/2005 - "This study examined the effect of topically applied TTO on nickel-induced contact hypersensitivity reactions in human dorsal skin. "
8.	OxazoloneIBA 03/01/2015 - "Previous studies suggested that immune cells bearing the FcRγ subunit are essential for oxazolone-induced contact hypersensitivity, but the biological functions of the FcRγ subunit in the process of sensitisation to oxazolone remain unknown. " 11/01/2007 - "In this study, we investigated the expression of CCR4, CCL17, and CCL22 in a mouse model of contact hypersensitivity to oxazolone. " 02/01/1989 - "In this study we evaluated the effects of CCB on in vivo cellular immunity by using contact sensitivity to oxazolone in mice. " 09/01/2015 - "Leukotriene B₄-leukotriene B₄ receptor axis promotes oxazolone-induced contact dermatitis by directing skin homing of neutrophils and CD8⁺ T cells." 03/01/2015 - "Our findings clearly indicate that, in an experimental mouse model, the FcRγ subunit positively regulates contact hypersensitivity to oxazolone without affecting the contact sensitisation process."
9.	Tacrolimus (Prograf)FDA LinkGeneric 01/01/2002 - "Studies have also suggested that topical tacrolimus may be effective in the treatment of acute contact dermatitis. " 07/01/2001 - "In human, small studies have reported tacrolimus ointment to be effective in controlling acute contact dermatitis. " 09/01/2004 - "Efficacy of tacrolimus ointment in the prevention and treatment of contact dermatitis." 03/01/2012 - "Tacrolimus is a promising alternative therapy for contact dermatitis patients as it is effective from the first month of treatment, well tolerated and offers similar therapeutic results to topical corticosteroid therapy." 01/01/2005 - "Treatment of protein contact dermatitis with topical tacrolimus."
10.	urushiolIBA 12/01/1999 - "Because human efficacy studies using CWA cannot be conducted, the efficacy will be demonstrated by the level of protection against poison ivy (urushiol) contact dermatitis in humans." 12/01/1999 - "The objective of the studies was to demonstrate that the contact sensitivity (CS) response to poison ivy/oak could be downregulated following treatment with a monoclonal antibody (mAb) reacting with the allergen urushiol. " 07/01/2015 - "Contact dermatitis (both local and systemic) represents the most-common side effect of urushiol chicken ingestion. " 04/01/2012 - "Urushiol-induced contact dermatitis is the medical name given to allergic rashes produced by the oil Urushiol. " 04/01/2012 - "Urushiol-induced contact dermatitis caused during Shodhana (purificatory measures) of Bhallataka (Semecarpus anacardium Linn.) fruit."

Therapies and Procedures

1.	Transplants (Transplant) 01/01/1988 - "It was also determined that the capacity of these animals to elicit contact hypersensitivity responses was significantly greater when compared with animals whose thymic grafts had been radiated. " 03/03/2003 - "CCL17-deficient mice mount diminished T cell-dependent contact hypersensitivity responses and display a deficiency in rejection of allogeneic organ transplants. " 03/01/1999 - "The contact hypersensitivity response (CHR) of rats, and their ability to induce a host versus graft reaction (HVGR) in the popliteal node were used to assess immune system as in vivo measures. " 01/01/1990 - "The data show that exposure to alcohol via the mother's milk was associated with long-term deficits in cellular immunity, including suppression of the local graft vs host and contact hypersensitivity responses. " 02/01/1984 - "Nonvital syngeneic, but not allogeneic, grafts were able to induce contact hypersensitivity, so it is proposed that the immunogenic signal derived from haptenated skin grafts consists of hapten and a class I or class II MHC gene product, but need not necessarily be delivered on a viable cell."
2.	Intraperitoneal Injections 01/01/2006 - "Intraperitoneal injection of GSPs-fed mice with a neutralizing anti-IL-12 antibody abrogated the protective effects of the GSPs against UVB-induced suppression of the contact hypersensitivity response. " 10/01/1993 - "Intraperitoneal injection of pentoxifylline into sensitized Balb/c and C3H/HeN mice before application of the challenging hapten dose resulted in a significant reduction of the outcome of the contact hypersensitivity reaction. " 07/01/2006 - "Intraperitoneal injection of mice treated with silymarin with an endotoxin-free neutralizing anti-IL-12 antibody abrogated the protective effects of the silymarin against UVB-induced suppression of the contact hypersensitivity response. " 12/01/2010 - "Furthermore, intraperitoneal injection of anti-α4β7 integrin neutralizing antibody elicit impaired contact hypersensitivity responses. " 07/01/2010 - "In an in vivo model of contact hypersensitivity in C57BL/6 mice, intraperitoneal injection of baclofen markedly alleviated signs of inflammation as well as recruitment of neutrophils, monocytes and lymphocytes into the skin. "
3.	Oral Administration 05/01/2014 - "Furthermore, we found that oral administration of GL attenuated the 2,4-Dinitro-1-fluorobenzene induced contact hypersensitivity (CHS) in animal models. " 03/01/2012 - "Oral administration of PLE to PA-induced allergic mice also led to a striking suppression of the development of contact dermatitis, ear swelling and lymph node weight. " 07/01/1994 - "The non-responsiveness induced by oral administration of AMLX to AMLX-induced animals was transient, and clinical prophylaxis by desensitization with oral AMLX may only increase the risk of systemic contact dermatitis. " 06/01/1983 - "Suppression of contact sensitivity and cell-mediated lympholysis by oral administration of hapten is caused by different mechanisms." 07/01/1951 - "Contact dermatitis due to cinnamon; recurrence of dermatitis following oral administration of cinnamon oil."
4.	Skin Care 03/01/2004 - "Improved skin condition resulted from the regular use of an effective skin conditioning hand moisturizer as part of a skin care regimen in work environments in which workers were prone to experiencing occupational irritant contact dermatitis." 01/01/2008 - "Preventive measures, including education, individual skin protection and proper skin care may contribute to the reduced incidence of occupational irritant contact dermatitis." 06/01/2015 - "The benefit of the combined application of protective creams and skin care products in the primary and secondary prevention of work-related contact dermatitis has been widely confirmed by recent clinical-epidemiological studies. " 01/01/2011 - "A scientifically based preventive program consisting of skin protection during work, cleaning and skin care after work has generally been recommended to prevent occupational contact dermatitis. " 05/01/2010 - "Skin care to minimise contamination and more effective ways of applying medical adhesive tape may be needed to prevent contact dermatitis."
5.	Hypophysectomy 08/01/1981 - "Treatment of normal rats with a potent prolactin antagonist drug, bromocriptine, was as effective in inhibiting contact sensitivity as was hypophysectomy. " 10/01/1986 - "Treatment of rats with tamoxifen citrate or pergolide mesylate was as effective in inhibiting antibody formation and contact sensitivity skin reactions as was hypophysectomy. "