Polyamines

11/01/1998 - "Because the prostate gland has a high polyamine content, by using the polyamine transporter for selective uptake into cancer cells, alkylating polyamines are likely to be highly effective against prostatic tumors. "
01/01/2015 - "Studies using mice with genetic alterations in epidermal polyamines suggest that they play key roles in tumor promotion and epithelial cell survival pathways, and recent clinical trials indicate that pharmacological inhibitors of polyamine metabolism show promise in individuals at high risk for NMSC. "
06/23/1995 - "Improved high-performance liquid chromatographic method for the determination of polyamines as their benzoylated derivatives: application to P388 cancer cells."
01/01/1983 - "Since other such specific kinetic markers are not available, polyamines should be clinically utilized to track tumor evolution and tumor response to therapy in those patients at high risk, in which such measurements could be translated into therapeutic efficacy."
05/01/1980 - "The urinary levels of polyamines are significantly higher in cancer in evolution than in cancer in remission. "

10/05/1999 - "We used MCF-7 breast cancer cells to investigate the efficacy of polyamines on the internalization of the TFO. "
01/01/2008 - "These four serum polyamines may be a good index to study both production and metabolism of polyamines, and a useful tool in assessment of the polyamine status of breast cancer patients."
10/01/2002 - "The aim of this study is to correlate the polyamines with apoptosis and clinico-pathologic events in Egyptian breast cancer patients. "
06/01/2002 - "In the present study, we report the importance of polyamines in protein phosphorylation in MCF-7 human breast cancer cells. "
05/01/2001 - "We believe that this technique will be useful for future studies aimed at expanding our knowledge of the role of ODC and polyamines (PA) in breast cancer biology."

01/01/1988 - "[Polyamines as a prognostic criterion of the duration of clinico-hematologic remission in acute leukemia in children]."
01/01/1977 - "Bone marrow polyamines in children with acute leukemia as related to remission status, therapy, and cellularity of specimens."
11/01/2003 - "In this study, we reported whether polyamines were capable of affecting apoptotic cell death triggered by H2O2 in leukemia cells or not. "
05/01/1984 - "Previous studies, however, have demonstrated that the polyamines are essential for proliferation, but not differentiation, of HL-60 human promyelocytic leukemia cells. "
10/23/1980 - "A preliminary study of polyamines in the bone-marrow plasma of adult patients with leukemia."

08/01/2003 - "Taken together, our results demonstrated that lytic infection of PRV was not influenced by addition of exogenous polyamines or depletion of endogenous polyamines; this conclusion was similar to earlier studies by using herpes simplex virus."
01/01/2015 - "Furthermore, changes in metabolism and content of polyamines indicate different defense mechanisms activated in flax in response to infection by pathogenic and non-pathogenic Fusarium strains. "
01/01/2015 - "Moreover, the considerable increase in the contents of cell wall-bound polyamines compared to the levels of free and conjugated polyamines may indicate that their main role during pathogen infection lies in strengthening of the cell wall. "
01/01/2015 - "It is well established that polyamines are essential for the growth and development of both plants and fungi, but their role in pathogen infection still remains unknown. "
01/01/2015 - "Polyamines are one of the many plant metabolites possibly involved in the plant response to infection. "

06/15/1987 - "This study suggests that notably for non-Hodgkin lymphoma patients with high tumour loads the constant monitoring of polyamines can provide information on pretherapeutic spontaneous tumour cell loss, the efficacy of chemotherapeutic combinations, the kinetics-, and (within certain limitations) the extent of therapeutically induced tumour cell death."
12/16/1997 - "Intracellular levels of polyamines in Krebs II lymphosarcoma cells in mice fed phytohaemagglutinin-containing diets are coupled with altered tumour growth."
06/15/1987 - "Urinary polyamines and their metabolites during new combination chemotherapeutic treatments of high grade non-Hodgkin lymphoma."
05/01/1982 - "The pretreatment concentrations of polyamines were determined in the 24-hr urine of 14 patients with widespread non-Hodgkin's lymphoma. "
05/01/1982 - "Urinary excretion of monoacetyl polyamines in patients with non-Hodgkin's lymphoma."