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SB328437

Also Known As:

methyl(2S)-2-(naphthalene-2-carbonylamino)-3-(4-nitrophenyl)propanoate

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        SB328437: 5
- Nitro Compounds: 66
  - SB328437: 5
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - SB328437: 5

Experts

1.	Ciapała, Katarzyna: 1 article (01/2021)
2.	Ciechanowska, Agata: 1 article (01/2021)
3.	Makuch, Wioletta: 1 article (01/2021)
4.	Mika, Joanna: 1 article (01/2021)
5.	Pawlik, Katarzyna: 1 article (01/2021)
6.	Rojewska, Ewelina: 1 article (01/2021)
7.	Chen, Linbao: 1 article (12/2020)
8.	Cheng, Bing: 1 article (12/2020)
9.	Cui, Xingang: 1 article (12/2020)
10.	Gan, Sishun: 1 article (12/2020)

Related Diseases

1.	Colitis 07/14/2022 - "In this study, we targeted CCR3-ligand interactions with a potent CCR3 receptor antagonist, SB328437, to alleviate eosinophil-associated immunological responses in the Winnie model of spontaneous chronic colitis. " 07/14/2022 - "Potent CCR3 Receptor Antagonist, SB328437, Suppresses Colonic Eosinophil Chemotaxis and Inflammation in the Winnie Murine Model of Spontaneous Chronic Colitis."
2.	Pain (Aches) 07/30/2023 - "The latest research provides irrefutable evidence that chemokine receptors are promising targets for pharmacotherapy; chemokine receptor antagonists can relieve pain of different etiologies, and most of them are able to enhance opioid analgesia, for example, the blockade of CCR1 (J113863), CCR2 (RS504393), CCR3 (SB328437), CCR4 (C021), CCR5 (maraviroc/AZD5672/TAK-220), CXCR2 (NVPCXCR220/SB225002), CXCR3 (NBI-74330/AMG487), CXCR4 (AMD3100/AMD3465), and XCR1 (vMIP-II). "
3.	Neoplasm Metastasis (Metastasis) 12/01/2020 - "Furthermore, in vivo experimental results revealed that blocking the positive loop through gankyrin knockdown or treatment with the CCR3 inhibitor SB328437 reversed the resistance to pazopanib and inhibited lung metastasis in ccRCC. "
4.	Necrosis 03/01/2012 - "Tumour necrosis factor-α (TNF-α) significantly induced phosphorylation of p38 MAPK, ERK, Akt and production of IL-8 from HCC cells, which were prevented by SB203580 (p38 MAPK inhibitor), PD98059 (ERK inhibitor), LY294002 and Wortmannin (PI3K inhibitor) and SB328437 (CCR3 inhibitor). "
5.	Inflammation (Inflammations) 07/14/2022 - "Potent CCR3 Receptor Antagonist, SB328437, Suppresses Colonic Eosinophil Chemotaxis and Inflammation in the Winnie Murine Model of Spontaneous Chronic Colitis."

Related Drugs and Biologics

1.	CCR3 Receptors
2.	p38 Mitogen-Activated Protein Kinases
3.	Chemokine Receptors
4.	Interleukin-8 (Interleukin 8)
5.	Opioid Analgesics (Opioids)
6.	Maraviroc
7.	Wortmannin
8.	N- (1- (3- (3,5- difluorophenyl)- 3- (4- methanesulfonylphenyl)propyl)piperidin- 4- yl)- N- ethyl- 2- (4- methanesulfonylphenyl)acetamide
9.	N- (1- (3- (4- ethoxyphenyl)- 4- oxo- 3,4- dihydropyrido(2,3- d)pyrimidin- 2- yl)ethyl)- N- pyridin- 3- ylmethyl- 2- (4- trifluoromethoxyphenyl)acetamide
10.	pazopanib

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Analgesia