p38 Mitogen-Activated Protein Kinases

A mitogen-activated protein kinase subfamily that regulates a variety of cellular processes including CELL GROWTH PROCESSES; CELL DIFFERENTIATION; APOPTOSIS; and cellular responses to INFLAMMATION. The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated in response to bacterial pathogens.

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Networked: 2705 relevant articles (105 outcomes, 301 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chang, Long-Sen: 13 articles (01/2016 - 07/2008)
2.	Higgins, Linda S: 12 articles (01/2010 - 02/2002)
3.	Kozawa, Osamu: 11 articles (06/2012 - 06/2005)
4.	Willette, Robert N: 10 articles (01/2013 - 04/2002)
5.	Noguchi, Koichi: 9 articles (02/2015 - 04/2004)
6.	Kipling, David: 9 articles (10/2013 - 09/2007)
7.	Davis, Terence: 9 articles (10/2013 - 09/2007)
8.	Protter, Andrew A: 9 articles (01/2010 - 06/2003)
9.	Medicherla, Satyanarayana: 9 articles (01/2010 - 08/2006)
10.	Chaudry, Irshad H: 9 articles (04/2009 - 07/2003)

Related Diseases

1.	Inflammation 04/01/2013 - "These results taken together with earlier studies on systemic administration of p38 MAPK inhibitors in rodents and humans suggest that direct intrapulmonary delivery of a p38 MAPK inhibitor is less effective in inhibiting inflammation and is associated with unexpected procoagulant effects in the bronchoalveolar space." 05/11/2011 - "Efficacy of NP202 was also associated with reduced p38 MAPK activation, inflammation and apoptotic cell death." 08/01/2013 - "In conclusion, our study provides novel data demonstrating that the p38 MAPK/NF-κB pathway is important in the induction of DOX-induced inflammation and cytotoxicity in H9c2 cardiac myocytes." 01/01/2013 - "The present study has demonstrated the new mechanistic evidence that exogenous H2S attenuates the DOX-induced inflammation and cytotoxicity by inhibiting p38 MAPK/NF-κB pathway in H9c2 cardiac cells. " 01/01/2013 - "The present study attempts to test the hypothesis that exogenous H2S might protect cardiomyocytes against the DOX-induced inflammation and cytotoxicity through inhibiting p38 MAPK/NF-κB pathway. "
2.	Neoplasms (Cancer) 08/15/2015 - "The altered phenotype of TAMs in apn(-/-) mice was associated with a marked decrease in phospho-p38 and treatment with a p38 MAPK inhibitor significantly reduced tumor size and increased MHC II expression on TAMs in WT mice, implying p38 MAPK signaling pathway may contribute to APN-mediated TAM polarization. " 04/12/2007 - "This tumor-prone phenotype of Wip1 is fully eliminated through attenuation of proliferation by activating the MKK6/p38 mitogen-activated protein kinases (MAPK) cascade in mice bearing a constitutively active form of MKK6. " 04/20/2015 - "Studies in mouse models have shown that the p38 MAPK pathway regulates homeostasis in colon epithelial cells but also plays an important role in colon tumor maintenance. " 08/01/2013 - "In this study, we analysed p38 MAPK isoform expression in oesophageal cancer cell lines as well as human normal and tumour tissue. " 01/01/2011 - "These studies illustrate that forced expression of Brk/PTK6 in non-transformed mammary epithelial cells mediates p38 MAPK phosphorylation and promotes increased cellular survival, delayed involution, and latent tumor formation. "
3.	Arthritis (Polyarthritis) 02/01/2008 - "Mechanisms of the joint-protective effects of p38 MAPK inhibitors in rodent arthritis." 09/13/2012 - "This compound represents a highly potent inhibitor of p38 MAP kinase with regard to in vivo activity in an adjuvant-induced arthritis model." 02/09/2012 - "Inhibition of MK2 has been shown to offer advantages over that of p38 MAPK in the development of cures for inflammatory diseases such as arthritis. " 02/01/2006 - "Both p38 MAPK inhibitors significantly reduced clinical signs of TNF-mediated arthritis. " 11/01/2010 - "Consequently, p38 MAPK inhibitors have attracted considerable interest as potential treatments of rheumatoid arthritis (RA), and studies in murine models of arthritis have yielded promising results. "
4.	Fibrosis (Cirrhosis) 04/01/2012 - "Inhibition of the p38 MAPK pathway ameliorates renal fibrosis in an NPHP2 mouse model." 02/01/2011 - "Long-term administration of Scu improved the cardiac function of MI rats by inhibiting interstitial fibrosis, and the mechanisms may involve the suppression of pro-fibrotic cytokine TGFβ1 expression and inhibition of p38 MAPK and ERK1/2 phosphorylation." 06/20/2009 - "Recent studies have suggested that p38 mitogen-activated protein kinases (MAPK) signalling pathway plays an important role in hepatic fibrosis. " 06/01/2012 - "We found that disruption of TβRII inhibited severe tubulointerstitial fibrosis in the UUO kidney, which was associated with the impairment of TGF-β/Smad3 signalling, but not with the ERK/p38 MAP kinase pathway. " 04/01/2012 - "Our results suggest that p38 MAPK and ERK signaling pathways independently affect renal fibrosis in inv mutant mice."
5.	Burns 03/01/2014 - "In this study, the authors evaluate the efficacy of topical p38 MAPK inhibition on full-thickness scald burns with immediate and delayed treatment. " 09/01/2009 - "We hypothesized that (1) severe burn up-regulates p38 MAPK activation and results in increased intestinal permeability via augmented expression of MLCK, and (2) inhibition of p38 MAPK will prevent the burn-induced increase in MLCK expression, resulting in improved intestinal barrier integrity. " 10/01/2009 - "In this study, we investigated the effects of local activated p38 MAPK inhibition on burn-induced cardiac dysfunction. " 03/01/2009 - "In this study, we tested whether p38 MAPK is involved in the response to first-degree burn of the hind paw. " 09/01/2003 - "These studies showed by more significant activation of p38 MAP kinase in KCs harvested from burn rats than from shams. "

Related Drugs and Biologics

1.	SB 203580
2.	Cytokines
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Phosphotransferases (Kinase)
5.	p38 Mitogen-Activated Protein Kinases
6.	Interleukin-6 (Interleukin 6)
7.	FR 167653
8.	SB 239063
9.	Curcumin
10.	imidazole

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Transplants (Transplant)
3.	Electroacupuncture
4.	Heart Transplantation (Grafting, Heart)
5.	Autologous Transplantation