GSK2578215A

an inhibitor of LRRK2 kinase; structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Parkinson Disease (Parkinson's Disease) 01/01/2018 - "Abbreviations: 6-OHDA: 6-hydroxydopamine; CHX: cycloheximide; dSY5Y: differentiated SH-SY5Y; g2019S tg: g2019S transgenic mouse; GSK/A-KI: GSK2578215A kinase inhibitor; HSP70: heat shock protein 70; LDH: lactose dehydrogenase; LRRK2: leucine rich-repeat kinase 2; MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; myc-GS LRRK2: myc-tagged g2019S LRRK2; NCL: nucleolin; PARP: poly(ADP-ribose) polymerase; PD: Parkinson's disease; PINK1: PTEN-induced putative kinase 1; pmoesin: phosphorylated moesin at t558; ROS: reactive oxygen species."
2.	Neuroblastoma 01/01/2016 - "We have used the human neuroblastoma cell line SH-SY5Y overexpressing Bcl-xL (SH-SY5Y/Bcl-xL) to clarify the effects of this mitochondrial protein on the control of mitochondrial dynamics and the autophagic processes which occur after the inhibition of leucine-rich repeat kinase 2 (LRRK2) with GSK2578215A. "

1.	Phosphotransferases (Kinase)
2.	Leucine (L-Leucine)
3.	Mitochondrial Proteins (Mitochondrial Protein)
4.	HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)
5.	Reactive Oxygen Species (Oxygen Radicals)
6.	Oxidopamine (6 Hydroxydopamine)
7.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
8.	Pyrrolidines
9.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
10.	Oxidoreductases (Dehydrogenase)