Benzamides

07/01/1998 - "The use of benzamides has to be considered efficacious in the prevention of delayed vomiting and nausea."
12/09/1989 - "[Value of substituted benzamides in controlling acute post-cisplatin emesis]."
03/01/2003 - "Among antiemetic drugs for the prevention of emesis, benzamides and in particular metoclopramide, are widely used in clinical practice. "
08/01/1988 - "A series of new substituted benzamides has been synthesized and evaluated for dopamine antagonist activity and for antagonism of cisplatin-induced emesis in the dog and in the ferret. "
06/01/1990 - "The antiemetic and locomotor effects of two substituted benzamides, zacopride and batanopride (BMY25801), were compared in ferrets after bilateral 60Co irradiation at 2, 4 or 6 Gy. Both zacopride and BMY25801 were effective against emesis and related signs. "

08/01/1995 - "One of the benzamides with a blood clearance faster than that of BZA--0.06 vs. 0.2% I D/g--6 h p.i. gave the same tumor to blood and to organ ratios as BZA at 12-18 h p.i. Based on these preclinical data we hope to obtain good tumoral images 6 h p.i. in scintigraphic studies in man."
10/26/2023 - "We have identified benzamides that inhibit HADC1 and HDAC2 at nanomolar concentrations, with antiproliferative activity at micromolar concentrations against A549 and SF268 cancer cell lines. "
12/01/2021 - "Imidazo-benzamides are considered to be good anti-cancer agents. "
07/05/2021 - "Ring-opening of five-membered heterocycles conjugated 4-isopropylresorcinol scaffold-based benzamides as HSP90 inhibitors suppressing tumor growth in vitro and in vivo."
10/01/2019 - "We have previously designed and synthesized a novel small molecule compound S1, 2-methoxy-3-phenylsulfonamino-5-(quinazolin-6-yl) benzamides and demonstrated its inhibition of PI3K and mTOR as well as the anti-tumor potential. "

01/01/1997 - "This article describes the synthesis of radioiodinated IMBA, N-(2-diethylaminoethyl)-3-[123I/131I]iodo-4-methoxybenzamide 8, its organ distribution, its comparison with BZA and other benzamides, and demonstrates the scintigraphic efficacy of the title compound with three melanoma patients. "
10/01/2001 - "Synthesis, characterization and comparative biodistribution study of a new series of p-iodine-125 benzamides as potential melanoma imaging agents."
04/01/2010 - "Preparation and biological evaluation of cyclopentadienyl-based 99mTc-complexes [(Cp-R)99mTc(CO)3] mimicking benzamides for malignant melanoma targeting."
01/01/2009 - "Indeed, several (99m)Tc complexes were found suitable for melanoma imaging; however, they were less eligible than radioiodinated benzamides. "
07/26/2007 - "Synthesis and evaluation of novel radioiodinated benzamides for malignant melanoma."

01/01/1990 - "The substituted benzamides or orthopramides are used to treat gastrointestinal and psychotic disorders. "
01/01/1992 - "Those patients in whom bromocriptine eliminated psychosis were treated later with the drugs belonging to the group of monosubstituted benzamides."

10/01/2022 - "In an effort to mitigate this hypoglycemia risk while maintaining the efficacy of the GK mechanism, we have investigated a series of amino heteroaryl phosphonate benzamides as ''partial" GK activators. "