Oxidopamine (6 Hydroxydopamine)

A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.

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Networked: 1682 relevant articles (55 outcomes, 240 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Morari, Michele: 13 articles (06/2015 - 02/2003)
2.	Dunnett, Stephen B: 13 articles (12/2013 - 04/2005)
3.	Männistö, Pekka T: 10 articles (01/2013 - 12/2004)
4.	Cenci, M Angela: 9 articles (12/2013 - 01/2002)
5.	Youdim, Moussa B H: 8 articles (03/2015 - 01/2002)
6.	Lane, Emma L: 8 articles (12/2013 - 03/2009)
7.	Islam, Fakhrul: 8 articles (04/2013 - 02/2003)
8.	Marti, Matteo: 8 articles (11/2012 - 02/2003)
9.	Svenningsson, Per: 7 articles (10/2015 - 03/2004)
10.	Calabresi, Paolo: 7 articles (11/2012 - 08/2002)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 06/01/2005 - "In this study, we examined whether they are also effective against the toxicity caused by 6-hydroxydopamine, both in vivo and in vitro, which may be relevant to Parkinson's disease (PD). " 08/30/2004 - "We tested this approach in the neurotoxic 6-OHDA model of Parkinson's disease in PC12 cells which has been widely used as an in vitro model for the investigation of the molecular pathogenesis of neuronal cell death and for novel treatment approaches. " 11/01/2015 - "Parkin has been shown to exert protective effects against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in different models of Parkinson disease. " 03/10/2010 - "rTMS was given to rats with Parkinson's disease induced by 6-OHDA, daily for 4 weeks to examine the protective effects. " 10/01/2009 - "Protective effects of neurotrophic factor-secreting cells in a 6-OHDA rat model of Parkinson disease."
2.	Neuroblastoma 12/01/2008 - "This study examined the protective effects of Asx on 6-hydroxydopamine (6-OHDA)-induced apoptosis in the human neuroblastoma cell line SH-SY5Y. " 09/01/2006 - "Previously, we have reported that pretreatment of human neuroblastoma SH-SY5Y cells with Apo enhances protection against 6-hydroxydopamine (6-OHDA)-induced cell death. " 08/01/2014 - "In this study, we demonstrate the antioxidant and protective properties of the aqueous extract of two commercial Polydiaceae plants - Drynaria fortunei (DF) and Pseudodrynaria coronans (PC) against 6-hydroxydopamine (6-OHDA)-induced oxidative damage in B35 neuroblastoma cells. " 01/03/2011 - "In the present study, we investigated the potential role of GSK3β in 6-hydroxydopamine (6-OHDA)-induced toxicity in human neuroblastoma cell line SH-SY5Y. " 12/01/2007 - "In this study, we investigated the neuroprotective effects of GLNVA on activated microglia-like cell mediated- and proparkinsonian neurotoxin 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in human dopaminergic neuroblastoma SH-SY5Y cells. "
3.	Hypertension (High Blood Pressure) 01/01/1990 - "Further studies using 6-OHDA in miniature swine may help to elucidate the mechanisms involved in maintaining hypertension in this animal model." 05/01/2000 - "The hypertension was abated and eliminated by 6-OHDA in the DS and DR strains, respectively. " 03/12/1986 - "Moreover, the present results may help to explain the attenuating effect of prehypertensive treatment with 6-OHDA on the development of hypertension." 01/01/1993 - "The intracerebroventricular administration of 6-OHDA in SHR at the age of 8th week not only prevented the development of hypertension, but also reduced the contents of NE and E in the brain regions, heart, aorta and plasma. " 01/01/1992 - "Splanchnicotomy predominantly over the root of mesenteric arteries or intracranioventricular injection of 6-hydroxydopamine prevented the development of hypertension in 2K-1C rats concomitant with the reduction of incorporation of 3H-proline into the non-collagenous protein in mesenteric arteries. "
4.	Seizures (Seizure) 01/01/1985 - "Injection of 6-OHDA caused a significant reduction in the average latency to onset of clonic-tonic convulsions. " 01/01/1994 - "These findings suggest that the efficacy of fetal LC tissue to promote reductions in seizure severity in GEPRs is increased following depletion of central NE by microinfusion of 6-OHDA." 01/01/1997 - "Three days after intracerebroventricular (i.c.v.) injection of 75 micrograms 6-hydroxydopamine (6-OHDA) in guinea pigs, PTZ induced seizures similar to those seen in rats. " 05/01/1994 - "Noradrenergic terminal fields as determinants of seizure predisposition in GEPR-3s: a neuroanatomic assessment with intracerebral microinjections of 6-hydroxydopamine." 01/01/1994 - "GEPR-3s seizure severities were increased in 39.5% of the animals after microinfusion of 6-OHDA into the region of the LC. "
5.	Nerve Degeneration 07/01/1996 - "Subthalamic nucleus lesion in rats prevents dopaminergic nigral neuron degeneration after striatal 6-OHDA injection: behavioural and immunohistochemical studies." 01/01/2015 - "Besides, VA also decreased neuron degeneration in the striatum and reversed the TH depletion observed in the mesencephalon of the untreated 6-OHDA groups. " 01/01/1971 - "Perivascular nerve degeneration produced in the hamster cheek pouch by 6-hydroxydopamine." 01/01/2012 - "AOE prevented and restored 6-hydroxydopamine (6-OHDA)-induced dopaminergic (DA) neuron degeneration and attenuated a deficit of locomotor activity in a zebrafish (Danio rerio) model of Parkinson's disease (PD). " 05/31/2002 - "Although 6-hydroxydopamine lesioning of the nigrostriatal dopamine system is a common method for producing animal models of dopamine neuron degeneration, there have been relatively few studies that have examined the effects of 6-hydroxydopamine on the dopamine systems of aged animals. "

Related Drugs and Biologics

1.	Dopamine (Intropin)
2.	Haloperidol (Haldol)
3.	Hydrogen Peroxide (Hydroperoxide)
4.	1-Methyl-4-phenylpyridinium (1 Methyl 4 phenylpyridinium)
5.	Amphetamine (Amfetamine)
6.	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)
7.	Neurotoxins
8.	Methamphetamine (Desoxyn)
9.	Norepinephrine (Noradrenaline)
10.	Glial Cell Line-Derived Neurotrophic Factor (GDNF)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Transplantation (Transplant Recipients)
3.	Injections
4.	Chemical Sympathectomy
5.	Ligation