Leucine (L-Leucine)

12/01/2012 - "Although short-term exercise (10 days) alone did not produce beneficial effects that would reduce tumor damage, host protein metabolism was improved when exercise was combined with a leucine-rich diet. "
01/01/2010 - "In summary, the exercise has beneficial effects by reducing tumor growth, leading to an improvement in protein turnover especially when in conjunction with a leucine-rich diet."
03/10/2009 - "In conclusion, a nutritional combination of high protein, leucine and fish oil reduced cachectic symptoms and improved functional performance in cancer cachectic mice. "
11/01/2003 - "A leucine-supplemented diet improved protein content of skeletal muscle in young tumor-bearing rats."
09/01/1991 - "(b) The alloreactive cells were granular since pretreatment of nude spleen cells with the lysosomotropic agent L-leucine methyl ester which eliminated LGL, simultaneously abolished the cytolysis of both allogeneic lymphocytes and YAC-1 tumor cells. "

12/01/1987 - "Leucine flux per kilogram body weight was significantly greater in newborns compared with adults, as was leucine oxidation and energy expenditure. "
04/01/2015 - "Compared with control groups, leucine supplementation significantly increased gain in body weight [mean differences 1.02 kg, 95%-CI (0.19, 1.85), p=0.02], lean body mass [mean differences 0.99 kg, 95%-CI (0.43, 1.55), p=0.0005], and body mass index [mean differences 0.33 kg/m2, 95%-CI (0.13, 0.53), p=0.001], when compared to the respective control groups. "
03/01/2014 - "Although a significant loss of body weight, FFM, and fat mass was noted in 13 days of high altitude exposure, FFM loss was not attenuated by leucine. "
03/01/2014 - "DIO mice decreased body weight and fat mass in response to chow, but supplementation with leucine did not affect these parameters. "
02/01/2013 - "Centrally administered leucine reduced 24 h food intake (by 32 %) and body weight. "

04/15/2010 - "In the present study, we have utilized additional biochemical and infection analyses to define further the structural basis of the interaction between ExoS and 14-3-3. An ExoS leucine-substitution mutant dramatically reduced the interaction potential with 14-3-3 suggesting that Leu422, Leu423, Leu426 and Leu428 of ExoS are important for its interaction with 14-3-3, its enzymatic activity and cytotoxicity. "
01/01/2011 - "In this study, we show that pathogen-induced Capsicum annuum hypersensitive induced reaction 1 (CaHIR1) and leucine-rich repeat 1 (CaLRR1) function as distinct plant PCD regulators in pepper plants during Xanthomonas campestris pv. vesicatoria infection. "
09/01/2002 - "We determined whole-body leucine kinetics in 4 boys and 3 girls aged 6-15 mo with edematous PEM and infection approximately 3 d after admission (study 1), when they were both infected and malnourished; approximately 11 d after admission (study 2), when infection had resolved but they were still anthropometrically malnourished; and at recovery (study 3), when weight-for-length was at least 90% of that expected. "
08/01/1997 - "We measured plasma Tr concentration, and fractional (FSR) and absolute (ASR) Tr synthesis rates with the use of a constant intragastric infusion of 2H3-leucine in 14 children with PEM, at 2 d postadmission (study 1), 8 d postadmission when infections were under control (study 2), and at recovery (study 3). "
01/01/1996 - "To study the effect of CMV infection on cell-mediated cytotoxicity against endothelial cells, peripheral blood mononuclear cells (MNC) were incubated with CMV-infected umbilical vein endothelial cells (CMV-UVEC) or mock-infected controls (M-UVEC) and lysis measured by [3H]leucine release. "

05/01/2014 - "Interestingly, several animal models of DBA have reported that leucine ameliorates the anemia phenotypes generated by RPS19 loss. "
09/13/2012 - "Dietary L-leucine improves the anemia in a mouse model for Diamond-Blackfan anemia."
09/13/2012 - "L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway."
01/01/2013 - "Recent studies have shown that l-leucine treatment of zebrafish and murine models of the 5q- syndrome and DBA results in a marked improvement in the anemia. "
09/13/2012 - "Administration of L-leucine significantly improved the anemia in Rps19-deficient mice (19% improvement in hemoglobin concentration; 18% increase in the number of erythrocytes), increased the bone marrow cellularity, and alleviated stress hematopoiesis. "

01/01/2011 - "In the present study we demonstrate how a single, simple dietary factor--leucine--can modify insulin resistance by acting on multiple tissues and at multiple levels of metabolism. "
06/01/2015 - "Response to Comment on Smith et al. Protein ingestion induces muscle insulin resistance independent of leucine-mediated mTOR activation. "
06/01/2015 - "Comment on Smith et al. Protein ingestion induces muscle insulin resistance independent of leucine-mediated mTOR activation. "
05/01/2015 - "Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation."
06/01/2014 - "To investigate the effects of catch-up growth (CUG) on the natch domain, leucine-rich repeat and PVD-containing protein 3 (NALP3) inflammasome pathway in visceral adipose tissue (VAT) and the mechanism of insulin resistance (IR) in CUG. "