Neuroblastoma

A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Also Known As:

Networked: 17756 relevant articles (606 outcomes, 2411 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Neoplasm Metastasis (Metastasis)
3.	Neuroblastoma
4.	Carcinoma (Carcinomatosis)
5.	Glioma (Gliomas)

Experts

1.	Maris, John M: 87 articles (12/2015 - 04/2003)
2.	Cheung, Nai-Kong V: 74 articles (11/2015 - 05/2002)
3.	Matthay, Katherine K: 60 articles (11/2015 - 04/2002)
4.	Reynolds, C Patrick: 52 articles (10/2015 - 06/2002)
5.	Kogner, Per: 52 articles (06/2015 - 01/2003)
6.	Cohn, Susan L: 50 articles (12/2015 - 01/2002)
7.	Speleman, Frank: 48 articles (11/2015 - 01/2003)
8.	Versteeg, Rogier: 47 articles (11/2015 - 03/2002)
9.	Nakagawara, Akira: 47 articles (07/2015 - 07/2002)
10.	Schramm, Alexander: 46 articles (10/2015 - 03/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neuroblastoma:

1.	3-Iodobenzylguanidine (Iobenguane)IBA 03/01/1997 - "This suggests that the positive effects observed by the treatment of neuroblastoma patients with the combination of HBO and [131I] MIBG are most likely not due to improved uptake or retention of MIBG in the neuroblastoma. " 11/01/1993 - "Metaiodobenzylguanidine (MIBG) is highly effective in the detection of neuroblastoma. " 07/01/1993 - "(4) Iodine-125 MIBG therapy in neuroblastoma: Is the improved energy deposition of 125I at extremely short range useful in the ablation of micrometastases? " 07/01/1985 - "Iodine-131 MIBG scintigraphy was more effective in demonstrating the extent of neuroblastoma spread than were conventional bone scan and CT in one patient, equal to these modalities in four cases, almost equal in two cases and significantly inferior in three cases. " 07/01/1993 - "Current controversies in the application of MIBG include (1)131I versus 123I as a label for imaging studies: Although improved image quality and reduced absorbed radiation dose are achieved with [123I]MIBG imaging, is it actually more efficacious in the detection of neuroblastoma? "
2.	Cisplatin (Platino)FDA LinkGeneric 01/01/2013 - "Cisplatin (CDDP) treatment of both miR-497 over-expressing cells and WEE1 inhibited cells, resulted in a significant increase in apoptosis in MNA cells, describing a synergistic effect and therefore a potential therapeutic for high-risk neuroblastoma. " 01/15/2008 - "A significant protection against cisplatin cytotoxicity was seen when the neuroblastoma cells were exposed to cisplatin directly combined with STS. " 02/01/1985 - "The efficacy of the combined treatment of cisplatin and radiation therapy for mouse C1 300 neuroblastoma was studied. " 11/01/2013 - "In this study we investigated the protein that interacts with RECK and the effects of RECK overexpression on the ER stress response and on cisplatin-induced cell death in neuroblastoma cells. " 06/01/2013 - "In the present study, we assessed MYCN gene expression using real-time RT-PCR following cisplatin treatment in three human neuroblastoma cell lines (UKF-NB-3, UKF-NB-4 and SK-N-AS) and their cisplatin-resistant counterparts. "
3.	Etoposide (VP 16)FDA LinkGeneric 06/01/1991 - "Etoposide is one of the agents which has been reported to be effective against advanced neuroblastoma clinically, if combined with other agents. " 10/01/1999 - "To describe the efficacy of oral etoposide against resistant stage 4 neuroblastoma. " 01/01/2012 - "The results of the study demonstrate that UKF-NB-4 neuroblastoma cells are sensitive both to etoposide and to VPA. " 02/01/2005 - "The aim of this study was to determine, by means of proteomics, potential markers of etoposide resistance in human neuroblastoma cell lines as well as to investigate protein levels and modifications possibly involved in the onset of resistance. " 01/01/1991 - "VP 16 carboplatinum in neuroblastoma: a SFOP phase II study. "
4.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 06/01/1985 - "Although the number of patients in this study was small and most had received prior therapy, our data do not support the efficacy of very high dose cyclophosphamide in the treatment of Stage IV neuroblastoma." 10/01/2007 - "A second study started in 2005 using Endoxan alone achieved a highly satisfactory survival rate of 73% for neuroblastoma in all stages except bilateral. " 11/01/1983 - "[Effect of cyclophosphamide on neuroblastoma and the bone marrow function in the experimental studies]." 01/01/2015 - "Based on the lymphodepleting effects of cyclophosphamide, we hypothesized that cyclophosphamide would synergize with the TLR9 agonist, CpG oligodeoxynucleotide (ODN), to produce a T cell-mediated anti-neuroblastoma effect. " 06/01/2014 - "We evaluated genetic variants associated with in vitro sensitivity to two derivatives of cyclophosphamide for association with clinical response in a separate replication cohort of neuroblastoma patients (n = 2,709). "
5.	DNA (Deoxyribonucleic Acid)IBA 10/01/2015 - "Targeting of MYCN by means of DNA vaccination is effective against neuroblastoma in mice." 07/01/2009 - "Survivin minigene DNA vaccination is effective against neuroblastoma." 11/01/2008 - "Detection of methylated-DCR2 in serum DNA has promise as a noninvasive assay for predicting prognosis and therapeutic efficacy in neuroblastoma, especially in non-MNA cases. " 04/15/2010 - "The objective of this study was to investigate the relationship between the composition of cationic SLN and their ability to condense plasmid DNA (pDNA) and to transfer it in neuroblastoma cells. " 06/12/2008 - "We performed a genomewide association study by first genotyping blood DNA samples from 1032 patients with neuroblastoma and 2043 control subjects of European descent using the Illumina HumanHap550 BeadChip. "
6.	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 09/01/2009 - "This study compared the antioxidant activity of various parts of Broussonetia papyrifera (BP), and further evaluated the protective effects of BP against hydrogen peroxide (H(2)O(2))-induced neuronal injury in human neuroblastoma SH-SY5Y cells. " 05/01/2014 - "the protective effects of a novel stilbene derivative, (e)-2-(3,4,5- trimethoxystyryl)-3,5,6-trimethylpyrazine (MStMp), on hydrogen peroxide (h2o2)-induced human derived neuroblastoma cell (Sh-Sy5y) damage and its molecular mechanisms were investigated. " 02/01/2005 - "In this study, neuroblastoma SH-SY5Y cells were treated with hydrogen peroxide in the presence of ascorbate in order to elucidate the mechanism(s) of protection against oxidative stress afforded by ascorbate. " 01/01/2015 - "The present study was performed to investigate the neuroprotective effects of LP extract (LPE) against hydrogen peroxide (H2O2)-induced injury in human neuroblastoma cells SH-SY5Y. " 01/01/2014 - "In vitro studies were carried out on the B104 neuroblastoma cell line demonstrating neuroprotection by the resistance to oxidative damage using hydrogen peroxide and the measure of cell viability by metabolic activity. "
7.	Topotecan (Hycamtin)FDA LinkGeneric 06/20/2005 - "Improved response in high-risk neuroblastoma with protracted topotecan administration using a pharmacokinetically guided dosing approach." 11/20/2011 - "Pilot induction regimen incorporating pharmacokinetically guided topotecan for treatment of newly diagnosed high-risk neuroblastoma: a Children's Oncology Group study." 01/01/2008 - "The study aims to use mathematical modeling and simulation to assess the relative contribution of topotecan systemic exposure and scheduling in the activity and myelosuppression of topotecan in pediatric patients with neuroblastoma. " 04/01/2005 - "Secondly, the other aim of this study was to determine whether it is feasible to combine this treatment with the topotecan in children with metastatic neuroblastoma. " 11/01/2015 - "Upfront treatment of high-risk neuroblastoma with a combination of 131I-MIBG and topotecan."
8.	Tretinoin (Retinoic Acid)FDA LinkGeneric 02/01/2013 - "The expression of GD1a increased by 13-cis retinoic acid (13cRA), which is a therapeutic drug for high risk neuroblastoma, thus leading to an improved sensitivity to HVJ-E in vitro. " 01/01/2001 - "9-cis retinoic acid (RA) is more effective than all-trans RA at inducing neuroblastoma differentiation in vitro, and has distinct biological properties with respect to its ability to promote apoptosis in N-type neuroblastoma cells. " 10/01/1997 - "These results suggest that 9-cis- and all-trans-retinoic acid have distinct biological properties and that 9-cis retinoic acid may be clinically effective in neuroblastoma by inducing both differentiation and apoptosis under an appropriate treatment regimen." 01/01/1996 - "These results show that cis-RA given at 160 mg/m2 to children achieved serum concentrations known to be effective against neuroblastoma in vitro, and the PK for cis-RA differs from that reported for trans-retinoic acid in children." 09/20/2014 - "In this study, DHM is applied to monitor the three-dimensional morphology change of retinoic acid-induced human neuroblastoma SH-SY5Y cells during Panax ginseng treatment. "
9.	Amyloid (Amyloid Fibrils)IBA 06/01/2006 - "Finally, the overexpression of chimeric mRNAs, containing the GFP coding sequence and APP 3'-UTR, dramatically reduced endogenous APP steady-state levels in SH-SY5Y neuroblastoma cells and suggests a novel approach to reduce the amyloid burden in AD patients." 12/01/2015 - "In this study, we used human neuroblastoma cell line SK-N-SH as a model and first observed that inhibiting ACAT1 can decrease the amyloid precursor protein (APP)-α-processing. " 10/01/2015 - "Both compounds were tested in vitro in two different neuroblastoma cellular models, one for amyloid precursor protein metabolism studies (BE(2)-M17) and another one specific for taupathology in AD (SH-SY5Y-TMHT441). " 05/01/2012 - "In the present study, we treated CHO cells (Chinese-hamster ovary cells) and SH-SY5Y neuroblastoma cells, that both constitutively express human wild-type APP (amyloid precursor protein) and process this to produce Aβ, with GSL-modulating agents to explore this relationship. " 11/01/2010 - "In this study, we provide evidence that an Aβ(25-35) fragment, which contains the cytotoxic sequence of the amyloid peptide, activates the intrinsic apoptotic pathway in SH-SY5Y human neuroblastoma cells expressing the HFE allelic variant H63D to a greater extent than in cells with wild-type (WT) HFE. "
10.	Interleukin-2 (IL2)IBA 02/01/2011 - "Dose finding study for the use of subcutaneous recombinant interleukin-2 to augment natural killer cell numbers in an outpatient setting for stage 4 neuroblastoma after megatherapy and autologous stem-cell reinfusion." 05/01/1993 - "Study of the immunophenotypic features of each patient's neuroblastoma cells before induction of MRD may be valuable in determining the likely effect of IL2 in predicting disease reactivation." 08/01/1991 - "Future studies of IL2 therapy in neuroblastoma should be undertaken earlier in the course of the disease." 08/01/1991 - "A phase II trial using interleukin-2 (IL2) and lymphokine-activated killer (LAK) cells was carried out in an attempt to treat children with end-stage neuroblastoma. " 06/01/1989 - "A phase-II study of adoptive immunotherapy with continuous infusion of interleukin-2 in children with advanced neuroblastoma. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 07/01/2003 - "The encouraging survival results of our cohort are consistent with the concept that surgery alone for local-regional neuroblastoma might be beneficial to the overall neuroblastoma population because many patients will never need chemotherapy (and will therefore be spared its potential toxicities), and most of those who do have widespread relapses are likely to be cured with contemporary treatments." 01/01/1984 - "Children less than 1 year old with localized and Stage IVS neuroblastoma had an extremely good prognosis (90% survival) and were usually cured without intensive chemotherapy. " 06/01/2002 - "In low-risk stage 3 neuroblastoma, standard-dose chemotherapy is associated with an excellent chance of being cured. " 06/01/2001 - "The authors present unusual clinicopathologic findings of a patient with neuroblastoma stage 4S that recurred 11 years after induction of complete remission with chemotherapy. " 05/01/1999 - "Patients who did not achieve complete remission (CR) with induction chemotherapy and surgery all died, suggesting that CR is essential for the cure of advanced neuroblastoma. "
2.	Heterologous Transplantation (Xenotransplantation) 11/01/2010 - "In addition, overexpression of miR-184 led to a significant reduction in tumour growth relative to negative control-treated cohorts in a xenograft model of neuroblastoma. " 11/01/2003 - "In addition, animal models of neuroblastoma (N-myc transgenic mice, and neuroblastoma xenografts) have been established to assess the efficacy of novel treatments. " 10/28/2014 - "Pharmacological or RNA interference-mediated inhibition of ERK5 suppressed the proliferation of neuroblastoma cells in culture and enhanced the antitumor efficacy of the ALK inhibitor crizotinib in both cells and xenograft models. " 06/01/1994 - "The pharmacokinetics, biodistribution and efficacy of the radiopharmaceutical 131I-meta-iodobenzylguanidine (131I-mIBG) were determined in murine xenografts of two human neuroblastoma cell lines, SK-N-SH and SK-N-BE(2c). " 06/01/1994 - "Pharmacokinetics and efficacy of 131I-meta-iodobenzylguanidine in two neuroblastoma xenografts."
3.	Immunotherapy 01/15/2015 - "Antibody-based immunotherapy has proven efficacy for patients with high-risk neuroblastoma. " 09/01/1985 - "Immunotherapy may be an effective treatment for neuroblastoma. " 08/01/2009 - "Immunotherapy shows promise in Phase III neuroblastoma trial." 09/01/2010 - "We previously showed that immunotherapy (IT) with IL-21-transduced neuroblastoma cells (Neuro2a/IL-21) cured 33% of syngeneic mice bearing systemic NB. " 04/01/1991 - "Enhanced resection and improved survival in murine neuroblastoma (C1300-NB) after preoperative immunotherapy."
4.	Radiotherapy 10/01/2003 - "Targeted radiotherapy with submyeloablative doses of 131I-MIBG is effective for disease palliation in highly refractory neuroblastoma." 03/01/1988 - "We advocate that patients with advanced neuroblastoma can obtain complete remission with the aid of surgery and radiotherapy, etc., if they are treated with the present protocol as the first therapy." 01/01/2012 - "Unfractionated radiotherapy may be beneficial in the treatment of IMN given the known radiosensitivity of neuroblastoma as well as its proclivity to metastasize as discrete lesions. " 06/01/2001 - "Patients with high-risk neuroblastoma in first remission received local radiotherapy (RT) totaling 21 Gy in twice-daily 1.5-Gy fractions. " 01/01/2013 - "Treatment with systemic radiotherapy in the form of low dose 131I-MIBG was easy to perform and effective in cases of disseminated neuroblastoma, demonstrating that this primary therapy can be used for palliative purposes."
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 07/18/2003 - "A phase III randomized trial showed that high-dose, pulse therapy with 13-cis-RA given after completion of intensive chemoradiotherapy (with or without autologous bone marrow transplantation) significantly improved event-free survival in high-risk neuroblastoma. " 09/01/2013 - "Myeloablative chemoradiotherapy and immunomagnetically purged autologous bone marrow transplantation has been shown to improve outcome for patients with high-risk neuroblastoma. " 10/14/1999 - "Treatment with myeloablative therapy and autologous bone marrow transplantation improved event-free survival among children with high-risk neuroblastoma. " 09/01/1990 - "[Relapsed stage I neuroblastoma successfully treated by allogeneic bone marrow transplantation in second remission: case report of a 7-year-old girl]." 06/01/1996 - "We report the toxicity and efficacy of a new conditioning regimen for bone marrow transplantation (BMT) in children with poor prognosis neuroblastoma (NBL). "