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Pyrrolidines

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Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 9

Experts

1.	Juillerat-Jeanneret, Lucienne: 2 articles (01/2010 - 06/2005)
2.	Gerber-Lemaire, Sandrine: 2 articles (01/2010 - 06/2005)
3.	Paoli, Paolo: 1 article (09/2015)
4.	Cardona, Francesca: 1 article (09/2015)
5.	Goti, Andrea: 1 article (09/2015)
6.	D'Adamio, Giampiero: 1 article (09/2015)
7.	Morrone, Amelia: 1 article (09/2015)
8.	Matassini, Camilla: 1 article (09/2015)
9.	Parmeggiani, Camilla: 1 article (09/2015)
10.	Catarzi, Serena: 1 article (09/2015)

Related Diseases

1.	Neoplasms (Cancer) 06/30/2005 - "Therefore, functionalized pyrrolidines have the potential to inhibit the growth of tumor cells and display selectivity for tumor cells when compared to normal cells." 02/14/2013 - "The design led to the synthesis of a family of highly substituted homochiral pyrrolidines with antiproliferative and antimetastatic activity in a murine model of colon carcinoma, as well as potent antiadhesive properties in several cancer cell lines in the low micromolar range. " 01/01/2010 - "Following the studies on swainsonine, a natural inhibitor of Golgi alpha-mannosidase II, which highlighted the inhibition of cellular mannosidases as a potential innovative approach for the treatment of cancer, several dihydroxylated pyrrolidines and analogues were developed as new potent inhibitors of alpha-mannosidases II able to induce antiproliferative effects in human cancer cells."
2.	T-Cell Leukemia (Leukemia, T Cell) 06/11/2015 - "Privileged Structures Meet Human T-Cell Leukemia Virus-1 (HTLV-1): C2-Symmetric 3,4-Disubstituted Pyrrolidines as Nonpeptidic HTLV-1 Protease Inhibitors."
3.	Myocardial Reperfusion Injury 05/01/2003 - "Recently, beta-phosphorylated nitrones and pyrrolidines have been reported to protect against myocardial reperfusion injury better than their nonphosphorylated analogs. "
4.	Pain (Aches) 06/13/2013 - "We describe herein the discovery of a series of 3-substituted pyrrolidines, exemplified by compound 1. Compound 1 is a selective SNRI in vitro and in vivo, has favorable ADME properties, and retains inhibitory activity in the formalin model of pain behavior. "
5.	Melanoma (Melanoma, Malignant) 06/30/2005 - "Functionalized pyrrolidines inhibit alpha-mannosidase activity and growth of human glioblastoma and melanoma cells."

Related Drugs and Biologics

1.	Swainsonine
2.	Mannosidases
3.	mannosyl-oligosaccharide 1,3 - 1,6-alpha-mannosidase
4.	nitrones
5.	alpha-Mannosidase (LAMAN)
6.	Piperidines
7.	Glucosylceramidase (Glucocerebrosidase)
8.	Glucosidases
9.	Formaldehyde (Formol)
10.	Alcohols