HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)

A class of MOLECULAR CHAPERONES found in both prokaryotes and in several compartments of eukaryotic cells. These proteins can interact with polypeptides during a variety of assembly processes in such a way as to prevent the formation of nonfunctional structures.

Also Known As:

Networked: 1419 relevant articles (30 outcomes, 150 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Multhoff, Gabriele: 30 articles (11/2015 - 10/2002)
2.	Gehrmann, Mathias: 16 articles (01/2015 - 10/2002)
3.	Stangl, Stefan: 10 articles (01/2015 - 08/2005)
4.	Jäättelä, Marja: 10 articles (05/2014 - 12/2002)
5.	Nylandsted, Jesper: 8 articles (02/2009 - 12/2002)
6.	Molls, Michael: 7 articles (01/2015 - 01/2008)
7.	Li, Wei: 7 articles (01/2015 - 12/2009)
8.	Guzhova, Irina V: 7 articles (05/2014 - 01/2006)
9.	Margulis, Boris A: 7 articles (05/2014 - 01/2006)
10.	Calderwood, Stuart K: 7 articles (01/2011 - 11/2002)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2011 - "The major stress-inducible heat shock protein 70 (Hsp70) is frequently overexpressed in highly aggressive tumors, and elevated intracellular Hsp70 levels mediate protection against apoptosis. " 12/01/2005 - "The microsatellite-unstable group showed significantly higher expression of heat shock protein 70 than the microsatellite-stable group (P = 0.006), and patients undergoing curative resections for unstable cancers had improved prognosis compared with their stable counterparts (P = 0.026). " 01/01/2010 - "Long-term protection against human papillomavirus e7-positive tumor by a single vaccination of adeno-associated virus vectors encoding a fusion protein of inactivated e7 of human papillomavirus 16/18 and heat shock protein 70." 01/01/2013 - "Up-regulation of heat shock protein 70 (HSP70) could be elicited primarily by heat in former studies, and this was proved to be associated with cancer progression. " 09/01/2011 - "In this study, we evaluated the release of heat shock protein 70 into the serum of cancer-bearing patients directly after radiofrequency ablation. "
2.	Reperfusion Injury 09/18/2001 - "Upregulation of heat shock protein 70 (HSP70) is beneficial in cardioprotection against ischemia-reperfusion injury, but the mechanism of action is unclear. " 04/05/2007 - "A number of studies suggest that the expression of heat shock protein 70 (HSP(70)) induced by heat stress are associated with protection against ischemia-reperfusion injury. " 03/01/2003 - "This study was designed to test the hypotheses that local somatothermal stimulation on the left median nerve territory increases myocardial heat shock protein 70 and that preconditioning of rats with local somatothermal stimulation protects the hearts against subsequent ischemia-reperfusion injury. " 08/01/2001 - "This study was designed to test the hypotheses that hepatic heat shock protein 70 (Hsp70) could be induced by local somatothermal stimulation (LSTS) on right seventh intercostal nerve territory and that preconditioning the rats with LSTS protects the liver from subsequent ischemia-reperfusion injury. " 06/01/1998 - "Previous studies indicate that heat shock protein 70 (hsp70) improves the myocardial tolerance to ischemia-reperfusion injury by a mechanism that is not well understood. "
3.	Ischemia 01/25/2005 - "Previous studies have strongly suggested that heat shock protein 70 (HSP70) has protective effects in ischemia/reperfusion in tissues such as brain, heart, and liver. " 01/01/2010 - "Overexpression of heat shock protein 70 kDa (HSP70) is known to confer cellular protection against ischemia-reperfusion (I/R) injury. " 12/01/1996 - "We have recently shown that the overexpression of a heat shock protein 70 (hsp 70) in a rat myogenic cell line confers protection against simulated ischemia. " 11/01/2003 - "In this experimental study in a rabbit model, renal parenchymal heat shock protein 70 (hsp70) levels were assessed in an attempt to evaluate the traumatic effects of high-energy shockwaves (HESW), which have been found to induce transient ischemia during the procedure. " 10/01/2003 - "Confocal studies showed that virtually all GAT-3-positive neurons in the perilesional cortex were TUNEL negative and coexpressed heat shock protein 70 kDa. These findings suggest that ischemia triggers a novel neuronal expression of GAT-3 that is greatest in the perilesional cortex and may contribute to the reported reduction in GABAergic inhibition."
4.	Infection 04/01/2014 - "In the current study, we have analysed the potential of Brugia malayi heat shock protein 70 (BmHsp70) as a vaccine candidate in a murine helminth infection. " 06/01/2013 - "The present study showed beneficial effects of therapeutic heat shock protein 70 (Hsp70) vaccination in cattle with naturally acquired chronic infection with Mycobacterium avium subsp. " 06/01/2009 - "Heat shock protein 70 (HSP70) is present in all organisms studied so far, and is a major immunogen in infections caused by pathogens including Leishmania spp. The aim of this study was to clone and express HSP70 from L. " 06/01/2015 - "In WSSV-infected red swamp crayfish Procambarus clarkii (Girard) cultured at 24 ± 1 °C, transcriptional levels of the heat shock protein 70 (Hsp70) gene showed a modest, 2.2-fold increase in haemocytes following 48 h post-infection (hpi). " 12/01/2014 - "Heat shock protein 70 is necessary for Rice stripe virus infection in plants."
5.	Fever (Fevers) 04/01/2001 - "Priming stresses such as ischemic preconditioning or mild hyperthermia have frequently been associated with improved survival of ischemic-reperfused cardiac muscle, such protection coinciding with induction of the stress-related heat shock protein 70 (Hsp70). " 02/01/2008 - "The purpose of this study was to delineate the effects of hyperthermia and physical exercise on the heat shock protein 70 (HSP70) response in circulating peripheral blood mononuclear cells (PBMCs). " 04/01/2010 - "Heat shock protein 70 was expressed in tumours treated with hyperthermia, but was not found in those tumours not exposed to hyperthermia. " 05/01/2009 - "Hyperthermia classic commentary: Activation of natural killer (NK) cells by heat shock protein 70, Gabriele Multhoff, International Journal of Hyperthermia, 2002;18:576-585." 03/01/2009 - "Following ecologically relevant episodes of hyperthermia between 33 degrees C and 50 degrees C, heat shock protein 70 (Hsp70) expression and hsp70/hsc70-4 activity in brains of nonflying laboratory-held bees increased by only two to three times baseline at temperatures 46-50 degrees C. "

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	NF-kappa B (NF-kB)
3.	Glutamine (L-Glutamine)
4.	Insulin (Novolin)
5.	DNA Vaccines
6.	Interleukin-2 (IL2)
7.	A-Form DNA (A-DNA)
8.	Small Interfering RNA (siRNA)
9.	1-phenyl-3,3-dimethyltriazene (PDT)
10.	Interferon-gamma (Interferon, gamma)

Related Therapies and Procedures

1.	Immunotherapy
2.	Transplantation (Transplant Recipients)
3.	Induced Hyperthermia (Thermotherapy)
4.	Resuscitation
5.	Moxibustion