Abstract | OBJECTIVES: MATERIALS AND METHODS: SH-SY5Y cells were pretreated with curcumin for 24 hr and transfected with human APOE4 gene using Lipofectamine 2000. Then, the effect of curcumin on the transfected cells was detected by ELISA, immunofluorescence staining and Western blot. RESULTS: CONCLUSION: This study suggests that APOE4 overexpression can induce cellular inflammatory damage, and pretreatment of curcumin could exert an anti-inflammatory effect by upregulating the expression of PPARγ to inhibit the activation of NF-κB signaling pathway.
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Authors | Minghui Wang, Jiejian Kou, Chunli Wang, Xiuying Yu, Xinmei Xie, Xiaobin Pang |
Journal | Iranian journal of basic medical sciences
(Iran J Basic Med Sci)
Vol. 23
Issue 12
Pg. 1576-1583
(Dec 2020)
ISSN: 2008-3866 [Print] Iran |
PMID | 33489032
(Publication Type: Journal Article)
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