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Nitric Oxide (Nitrogen Monoxide)

A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Also Known As:
Nitrogen Monoxide; Endogenous Nitrate Vasodilator; Mononitrogen Monoxide; Nitric Oxide, Endothelium-Derived; Endothelium-Derived Nitric Oxide; Monoxide, Mononitrogen; Monoxide, Nitrogen; Nitrate Vasodilator, Endogenous; Nitric Oxide, Endothelium Derived; Oxide, Nitric; Vasodilator, Endogenous Nitrate; Nitrogen oxide (NO)
Networked: 35484 relevant articles (1255 outcomes, 4219 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Gladwin, Mark T: 71 articles (01/2021 - 02/2002)
2. Dehpour, Ahmad Reza: 53 articles (01/2022 - 04/2002)
3. Lundberg, Jon O: 47 articles (01/2022 - 02/2005)
4. Tain, You-Lin: 43 articles (03/2022 - 01/2007)
5. Tanus-Santos, Jose E: 40 articles (02/2022 - 01/2002)
6. Ghasemi, Asghar: 38 articles (01/2022 - 09/2006)
7. Zapol, Warren M: 38 articles (01/2022 - 04/2002)
8. Bloch, Kenneth D: 38 articles (11/2018 - 04/2002)
9. Malinovschi, Andrei: 37 articles (01/2022 - 03/2010)
10. Barnes, Peter J: 37 articles (09/2016 - 01/2002)

Related Diseases

1. Pulmonary Hypertension
2. Inflammation (Inflammations)
3. Asthma (Bronchial Asthma)
4. Hypoxia (Hypoxemia)
5. Reperfusion Injury

Related Drugs and Biologics

1. Nitric Oxide Synthase (NO Synthase)
2. Arginine (L-Arginine)
3. Antioxidants
4. Cytokines
5. Vasodilator Agents (Vasodilators)
6. Malondialdehyde (Propanedial)
7. Biomarkers (Surrogate Marker)
8. Glutathione (Reduced Glutathione)
9. Superoxide Dismutase
10. Proteins (Proteins, Gene)

Related Therapies and Procedures

1. Therapeutics
2. Extracorporeal Membrane Oxygenation
3. Cardiopulmonary Bypass (Heart-Lung Bypass)
4. Artificial Respiration (Mechanical Ventilation)
5. Oral Administration