Curcumin

A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.

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Networked: 3798 relevant articles (523 outcomes, 1122 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Aggarwal, Bharat B: 66 articles (12/2015 - 01/2002)
2.	Sarkar, Fazlul H: 36 articles (01/2016 - 11/2004)
3.	Liang, Guang: 25 articles (11/2015 - 03/2009)
4.	Chung, Jing-Gung: 21 articles (10/2015 - 05/2003)
5.	Banerjee, Sanjeev: 19 articles (12/2015 - 12/2002)
6.	Snyder, James P: 17 articles (03/2015 - 07/2004)
7.	Chen, Yan: 17 articles (01/2015 - 01/2002)
8.	Jaggi, Meena: 16 articles (11/2015 - 01/2010)
9.	Steward, William P: 16 articles (08/2015 - 01/2002)
10.	Padhye, Subhash: 15 articles (12/2015 - 08/2009)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2015 - "As curcumin has a potent anti-inflammatory effect with strong therapeutic potential against a variety of cancers, our present study aims to investigate its curative effects and the possible mechanisms of action against DENA-induced HCC in male rats. " 01/01/2013 - "Extensive research over last few decades has shown that curcumin is a potent anti-inflammatory agent with powerful therapeutic potential against a variety of cancers. " 01/01/2012 - "This improved the bioavailability of curcumin, a potent natural anticancer drug, making it suitable for cancer therapy. " 05/15/2010 - "Compared to normal cells baseline expression of SOCS-3 was high in cancer cells and a marked decrease in SOCS-3 expression was seen following curcumin treatment. " 12/09/2010 - "High content analysis technology coupled with biochemical studies showed that this new class of 4-arylidene curcumin analogues exhibits significantly improved NF-κB inhibition activity over the parent compound curcumin, at least in part by inhibiting IκB phosphorylation and degradation via IKK blockage; selected 4-arylidene curcumin analogues also reduced the tumorigenic potential of cancer cells in a clonogenic assay. "
2.	Inflammation 06/01/2012 - "This was associated with a significant reduction in macrophage infiltration and inflammation in both the heart and liver; moreover, curcumin-treated infected mice displayed a 100% survival rate in contrast to the 60% survival rate commonly observed in untreated infected mice. " 01/01/2011 - "These multiple mechanisms of protection against inflammation and oxidative damage make ginger and curcumin particularly promising natural agents in fighting the ravages of aging and degenerative diseases, and need to be paid more attention by studies." 11/01/2012 - "Preclinical studies in experimental animals have shown that curcumin, an active principle of the Indian spice turmeric (Curcuma longa Linn) is effective in preventing or ameliorating UC and inflammation. " 02/01/2013 - "In this study, we also found the signaling pathway and the possible target gene of the protective effects of curcumin on endotoxin-induced renal inflammation. " 11/01/2012 - "Curcumin, a polyphenolic compound derived from turmeric, has protective effects on myocardial injury through attenuation of oxidative stress and inflammation. "
3.	Breast Neoplasms (Breast Cancer) 01/01/2014 - "Good results in the prevention and the treatment of breast cancer could be ensured by curcumin nanoparticles coated with albumin, known as nanocurcumin. " 01/01/2009 - "The uptake and efficacy of SF-coated curcumin was significantly higher (p < 0.001) than SFCS-coated curcumin in both low and high Her2/neu expressing breast cancer cells. " 01/01/2009 - "In conclusion, SF-derived curcumin nanoparticles show higher efficacy against breast cancer cells and have the potential to treat in vivo breast tumors by local, sustained, and long-term therapeutic delivery as a biodegradable system." 08/01/2013 - "Curcumin improves the therapeutic efficacy of Listeria(at)-Mage-b vaccine in correlation with improved T-cell responses in blood of a triple-negative breast cancer model 4T1." 07/05/2015 - "Protective effects of dendrosomal curcumin on an animal metastatic breast tumor."
4.	Wounds and Injuries (Trauma) 04/01/2013 - "Curcumin treatment significantly improved animal survival and reduced the pathologic injuries in the intestines. " 10/01/2014 - "Curcumin, a yellow pigment extracted from Carcuma longa, has been demonstrated to have extensive pharmacological activity in various studies, and it exhibits protective effects on injuries involving a number of human organs. " 05/01/2012 - "[Experimental study of signal transduction mechanism of curcumin protective effects on radiation-induced vascular endothelial injuries]." 11/01/2011 - "[Protective effects of curcumin on vascular endothelial injuries induced by radiation]." 09/01/1999 - "In this study, we have evaluated the efficacy of curcumin treatment by oral and topical applications on impaired wound healing in diabetic rats and genetically diabetic mice using a full thickness cutaneous punch wound model. "
5.	Body Weight (Weight, Body) 05/01/2012 - "Curcumin-treated rats had improved motor function compared with controls starting from Week 1. Body weight gain significantly improved, correlating with improved Basso-Beattie-Bresnahan scores. " 01/01/2014 - "Stem cell therapy improved recovery from moderate SCI, however, it had a limited effect on recovery after severe SCI. Curcumin stimulated NSC proliferation in vitro, and in combination with stem cell therapy, induced profound recovery from severe SCI as evidenced by improved functional locomotor recovery, increased body weight, and soleus muscle mass. " 05/01/2011 - "Importantly, Pkd1-deletion mice that were treated with curcumin and killed at an early stage of PKD displayed improved renal histology and reduced STAT3 activation, proliferation index, cystic index, and kidney weight/body weight ratios. " 08/01/2010 - "Sub-acute-toxicity study proved the safety of the formulation for prolonged administration at the commonly used therapeutic dose of 100mg/kg of body weight of curcumin and at twice the therapeutic dose. " 08/01/2010 - "The formulation was found to be non-toxic at the dose equivalent to 2000 mg/kg of body weight of curcumin in the acute-toxicity study. "

Related Drugs and Biologics

1.	resveratrol
2.	NF-kappa B (NF-kB)
3.	Collagen
4.	Curcumin
5.	Doxorubicin (Adriamycin)
6.	Micelles
7.	Glucose (Dextrose)
8.	Amyloid (Amyloid Fibrils)
9.	DNA (Deoxyribonucleic Acid)
10.	Fluorouracil (Carac)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Chemoprevention
3.	Drug Therapy (Chemotherapy)
4.	Root Planing
5.	Therapeutics