Abstract | BACKGROUND: Wooden breast (WB) myopathy in broiler chickens is a growing challenge for the poultry industry. Previous multi-omic data have implied that the pathogenesis of WB is associated with the activation of immune system and inflammatory response. However, the intricate mechanisms are not fully understood. This study was therefore conducted to systematically investigate the morphology, expression of cytokines as well as the underlying signaling pathways regulating the inflammatory response in pectoralis major (PM) muscle of WB myopathic broilers. RESULTS: CONCLUSION: The results indicated an immune disorder and a systemic inflammation response in WB myopathic broilers, which might be related to a synergetic effect of TLRs and NF-κB pathway. © 2020 Society of Chemical Industry.
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Authors | Tong Xing, Dan Luo, Xue Zhao, Xinglian Xu, Jiaolong Li, Lin Zhang, Feng Gao |
Journal | Journal of the science of food and agriculture
(J Sci Food Agric)
Vol. 101
Issue 1
Pg. 279-286
(Jan 15 2021)
ISSN: 1097-0010 [Electronic] England |
PMID | 32623748
(Publication Type: Journal Article)
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Copyright | © 2020 Society of Chemical Industry. |
Chemical References |
- Cytokines
- Interleukin-8
- NF-kappa B
- Tumor Necrosis Factor-alpha
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Topics |
- Animals
- Chickens
- Cytokines
(genetics, immunology)
- Interleukin-8
(genetics, immunology)
- Male
- Muscular Diseases
(genetics, immunology, veterinary)
- NF-kappa B
(genetics, immunology)
- Poultry Diseases
(genetics, immunology)
- Tumor Necrosis Factor-alpha
(genetics, immunology)
- Up-Regulation
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