Muscular Diseases (Myopathy)

08/01/2015 - "An empirical treatment with carnitine may be beneficial for patients before an accurate diagnosis of lipid storage myopathy is made."
01/01/1984 - "The latter was treated successfully with oral carnitine but the myopathy persisted. "
10/01/1982 - "We suggest that some cases of idiopathic lipid storage myopathy may be safely and effectively treated with carnitine and medium-chain triglyceride diet."
01/01/1988 - "Although the primary metabolic defect has yet to be elucidated, the present study indicates that lipid storage myopathy in the absence of carnitine deficiency can be complicated with RS-like episodes."
03/30/1986 - "[Carnitine-deficient myopathy successfully treated with bicarnesine; clinico-chemical and muscle morphology studies]."

04/01/2013 - "The aim of the present study was to evaluate the possible effects of Q10 and selenium supplementation on statin-induced myopathy (SIM), both for subjective symptoms and muscle function. "
01/01/1985 - "A preliminary study on selenium content of forages and local by-products in the Tadla area (Morocco) in connection with ovine nutritional myopathy."
11/01/2015 - "This case highlights the importance of assessing plasma selenium levels in horses with clinical signs of pasture myopathy as this deficiency may be a contributing or exacerbating factor. "
12/01/2012 - "Low serum selenium concentrations are common in hospitalised adult horses while nutritional myopathy is rare in these animals."
12/01/2012 - "No associations were identified between nutritional myopathy and selenium status in horses between 30 days and 2 years of age or in horses more than 2 years of age. "

02/01/1985 - "High-dose corticosteroids were dramatically effective in inducing remission, with resolution of all signs and symptoms of the myopathy and normalization of CPK."
08/01/2000 - "These improved initially with more frequent infusions of hdIVIg but oral corticosteroids were required to treat worsening myopathy. "
12/01/1996 - "A MEDLINE search (1985 to July 1995, English language) yielded case reports and clinical studies involving myopathy or weakness associated with the use of NMBAs and/or corticosteroids. "
04/01/1995 - "The present study was designed to evaluate the ability of specific inspiratory muscle training (SIMT) to prevent the effects of a therapeutic dosage of corticosteroids on inspiratory muscle function in patients receiving the drug for diseases other than pulmonary, with no underlying respiratory or muscular disease. "
01/01/2011 - "Acute myopathy caused by exogenous corticosteroids is rare, usually with intravenous corticosteroids at high doses. "

07/01/2010 - "Zidovudine myopathy may be a constraint for use of the drug in the western population; however, it is a well-tolerated drug as regards myopathy in our study on Indian patients."
07/01/2010 - "Literature is replete with studies on zidovudine-induced myopathy after prolonged use (use beyond 270 days on an average). "
07/01/2010 - "Zidovudine-induced myopathy: A study in Indian patients."
03/01/1997 - "Analysis of myopathy in a placebo-controlled zidovudine trial."
10/01/1992 - "The aim of this study was to evaluate the frequency of appearance of myopathy in a group of patients treated with zidovudine. "

01/01/1996 - "The results of this study suggested that the significant improvement in exercise capacity observed after this short-term endurance training period may have arisen mainly through peripheral mechanisms, associated with the possible decrease in plasma catecholamine concentrations and reversal of muscle deconditioning and/or prednisone-induced myopathy."
07/01/1985 - "Evidence that prednisone-induced myopathy is reversed by physical training."
08/01/1972 - "Lipid storage myopathy responsive to prednisone."
12/01/1980 - "Marked improvement in the myopathy occurred after commencement of prednisone and thiamine and was maintained following withdrawal of these drugs. "
07/01/1984 - "Oral steroids, 40 to 80 mg prednisone daily, were moderately effective in reducing progressive soft tissue inflammatory signs, but were less effective in controlling myopathy and lid retraction. "

12/01/2003 - "This report describes a case of acute steroid-induced myopathy following a single dose of oral prednisolone. "
12/01/2003 - "Steroid-induced myopathy following a single oral dose of prednisolone."
08/01/1993 - "Finally, 90 min daily of endurance exercise did not antagonize prednisolone-induced myopathy in either the diaphragm or the plantaris."
08/01/1985 - "Progressive diaphyseal dysplasia mimicking childhood myopathy: clinical and biochemical response to prednisolone."
01/01/1984 - "[Value of the prednisolone test in myopathy diagnosis]."

09/01/2014 - "Results of a muscle biopsy showed necrotizing myopathy with minimal inflammatory cell infiltrate and increased major histocompatibility class I antigen expression in muscle fibers. "
11/01/1993 - "The myopathy caused by HIV and HTLV-1 is not due to direct infection of the muscle by these viruses, but rather due to an immunopathologic process triggered by the viruses, mediated by autoaggressive CD8+ cells in the context of MHC-class I antigen expression. "
03/01/1989 - "Major histocompatibility complex class I antigen expression, immunolocalization of interferon subtypes, and T cell-mediated cytotoxicity in myopathies."
04/19/1990 - "We conclude that long-term therapy with zidovudine can cause a toxic mitochondrial myopathy, which coexists with a T-cell-mediated inflammatory myopathy that is restricted to MHC-I antigen, and is indistinguishable from the myopathy associated with primary HIV infection or polymyositis in HIV-seronegative patients."
01/01/1997 - "Immunohistology for major histocompatibility complex class I antigen and histochemical reaction for cytochrome coxidase are helpful in the correct classification of a myopathy as HIV polymyositis or zidovudine myopathy."

04/01/2008 - "These findings demonstrate that collagen VI myopathies can be effectively treated with drugs acting on the pathogenic mechanism downstream of the genetic lesion, and they represent an important proof of principle for the potential therapy of genetic diseases."
09/01/2014 - "Skin-cultured fibroblasts showed intracellular retention of collagen 6 (COL6), muscle magnetic resonance imaging was typical of COL6 myopathy, and molecular studies identified a COL6 gene mutation (COL6A2 c.954+2T>C). "
01/01/2014 - "Here we evaluated if Col6a1 null mice, an established animal model for the muscle changes in collagen VI related myopathies, are also suitable for the study of mechanisms leading to the skin pathology. "
01/01/2014 - "Col6a1 null mice as a model to study skin phenotypes in patients with collagen VI related myopathies: expression of classical and novel collagen VI variants during wound healing."
12/01/2013 - "These findings improve our knowledge of the natural history of the collagen VI-related myopathies, enabling proactive optimization of care and preparing this patient population for clinical trials. "

01/01/2015 - "To evaluate the efficacy of coenzyme Q10 (CoQ10) supplementation on statin-induced myopathy. "
02/01/2014 - "Statins' effect on plasma levels of Coenzyme Q10 and improvement in myopathy with supplementation."
07/01/1985 - "These results indicate that the impaired myocardial function of such patients with muscular disease may have some association with impaired function of skeletal muscle, both of which may be improved by CoQ10 therapy. "
03/01/2015 - "The current study investigates if supplementing with CoQ10 could ameliorate statin induced myopathy. "
02/01/2015 - "A randomized trial of coenzyme Q10 in patients with confirmed statin myopathy."

02/01/2009 - "The present study suggests that changes in the OATP1B1 activities may have a small and a large impact on the therapeutic efficacy and side effect (myopathy) of pravastatin, respectively, whereas those in the MRP2 activities may have opposite impacts (i.e., large and small impacts on the therapeutic efficacy and side effect)."
12/01/2010 - "Therefore, variation in the OATP1B1 activities will have small and large impacts on the therapeutic efficacy and adverse effect (myopathy) of pravastatin, respectively, whereas that affecting the MRP2 activities may have an opposite effect (i.e., large and small impacts on the therapeutic efficacy and side effect). "
06/01/2009 - "In the present study, we analyzed the function of a novel mutation (c.1628T>G, p.Leu543Trp) in the solute carrier organic anion transporter (SLCO) 1B1 gene, encoding organic anion transporting polypeptide (OATP) 1B1, which was identified in a patient with pravastatin-induced myopathy. "
07/01/2005 - "Object of the present study was to study the influence of SLCO1B1*5, *15 and *15+C1007G, a novel haplotype found in a patient with pravastatin-induced myopathy, on the functional properties of OATP1B1 by transient expression systems of HEK293 and HeLa cells using endogenous conjugates and statins as substrates. "
06/01/2009 - "Functional analysis of a mutation in the SLCO1B1 gene (c.1628T>G) identified in a Japanese patient with pravastatin-induced myopathy."

05/15/2005 - "The purpose of this study was to determine the efficacy of resistance exercise in reversing skeletal muscle myopathy in heart transplant recipients. "
01/01/2012 - "Transplantation of muscle precursor cells is of therapeutic interest for focal skeletal muscular diseases. "
07/01/2010 - "(4) Complex nonobstructive hypertrophic myopathy can be thought of as a type of neoplastic overgrowth, and aggressive resection of even midcavitary obstructive lesions should be considered as a viable alternative to primary transplantation. "
08/01/2009 - "The development of muscle stem cells for transplantation or gene transfer in patients with muscle disorders has become more attractive and challenging recently. "
08/27/2006 - "Transfection of IGFII gene into ES cells may be applicable for transplantation therapy of muscle damage due to injury and myopathies."

11/01/2014 - "Safety and efficacy of combined immunosuppression and orbital radiotherapy in thyroid-related restrictive myopathy: two-center experience."
01/01/2007 - "Those with a history of myopathy, neuropathy, recurrent disease, or previous radiotherapy were excluded. "
04/01/2002 - "Orbital radiotherapy alone is ineffective in treating restrictive thyroid myopathy and improving binocular function."
03/01/2002 - "It has been observed that the duration of the orbitomyopathy, severity of myopathy of the deviation angle, and the modality of treatment prior to surgery (radiotherapy and corticotherapy) did not influence surgical outcome. "
02/01/2005 - "Two groups of 20 patients each matched for gender and age were selected according to the type of neck dissection received: patients in group A had selective neck dissection involving clearance of levels II-IV, and patients in group B had clearance of levels II-V. The inclusion criteria were as follows: no preoperative signs of myopathy or neuropathy, no postoperative radiotherapy, and absence of locoregional recurrence. "

10/01/2012 - "[Necrotizing myopathy associated with anti-SRP auto-antibodies: transient efficacy of a therapeutic strategy associating plasma exchanges and rituximab]."
05/01/2014 - "We describe the effectiveness of combinatorial therapy with plasma exchanges and methylprednisolone pulses followed by intravenous cyclophosphamide in a young girl with anti-signal recognition particle 54 (SRP54) antibody-associated myopathy. "
05/01/2014 - "Serum levels of anti-SRP54 antibodies reflect disease activity of necrotizing myopathy in a child treated effectively with combinatorial methylprednisolone pulses and plasma exchanges followed by intravenous cyclophosphamide."
05/01/2006 - "We report two patients with myopathy associated with anti-signal recognition particle Ab, refractory to conventional therapy, who were treated with prednisone and plasma exchange, followed by rituximab. "
05/01/2006 - "Marked efficacy of a therapeutic strategy associating prednisone and plasma exchange followed by rituximab in two patients with refractory myopathy associated with antibodies to the signal recognition particle (SRP)."

08/01/1978 - "For the diagnosis of denervation the most useful measurement was that of potential duration; for the detection of myopathies amplitude determinations were also very useful. "
06/01/2015 - "In this study we investigated underlying mechanisms of apoptosis-related pathways in muscles with different fiber type composition in a rat model of CIM using denervation and glucocorticoid administration (denervation and steroid-induced myopathy, DSIM). "
08/01/2002 - "In skeletal muscle, very few studies have been done under specific physiological (e.g., exercise) and pathophysiological (e.g., dystrophies, denervation, myopathies) conditions. "
03/01/2001 - "This study demonstrates that inclusion body myopathy is identifiable in patients with STC and that it may arise secondary to denervation."
09/09/1966 - "Histochemical studies on denervation, chemically induced and hereditary forms of myopathies."

05/15/2012 - "These studies suggest that inorganic nitrate could be an inexpensive therapeutic agent for long-term oral administration in preventing DOX-induced cardiac toxicity and myopathy during the prolonged pathological process. "
10/23/2015 - "Myopathy in knockout mice was completely rescued by the oral administration of MVA. "
01/01/2009 - "She was given a diagnosis of sarcoid myopathy, and motor weakness and abnormal intensity signals on T2WI in this patient were dramatically improved with oral administration of prednisolone (40 mg/day)."
01/01/2014 - "Given the effects of oral administration of L-carnitine further clinical study is necessary in order to assess the potential beneficial effects in equine patients suffering from metabolic myopathies such as acquired multiple acyl-CoA dehydrogenase deficiency. "
03/01/2002 - "The plasma creatine phosphokinase (CPK) level as a marker of myopathy in normal rats was screened under urethane infusion after oral administration of HCRI alone or with BF coadministration. "