Abstract | WHAT IS KNOWN AND OBJECTIVE: The impact of metformin on thyrotropin levels is sex-dependent. No previous study has assessed whether sex steroids determine metformin action on thyrotrope and thyroid cell functioning. The aim of the present study was to compare the effect of this agent on hypothalamic-pituitary-thyroid axis activity and thyroid function tests between women receiving oral contraceptive pills and women not using any contraception. METHODS: RESULTS AND DISCUSSION: The study groups differed in oestradiol, gonadotropins and prolactin levels and in structure parameter inference approach (SPINA)-GT. In both groups, metformin reduced glucose levels, homeostasis model assessment 1 of insulin resistance index (HOMA1-IR), thyrotropin levels and Jostel's thyrotropin index, as well as increased SPINA-GT. In women receiving oral contraceptive pills, the drug slightly decreased serum prolactin levels. The impact on metformin on HOMA1-IR, thyrotropin, prolactin, Jostel's thyrotropin index and SPINA-GT was more pronounced if women received oral contraception, as well as more pronounced in patients treated with higher doses of this agent. Treatment-induced changes in thyrotropin and Jostel's thyrotropin index correlated with their baseline values, baseline levels of oestradiol and gonadotropins, as well as with the degree of a reduction in HOMA1-IR. WHAT IS NEW AND CONCLUSION: This study is the first one to have shown that oral oestrogens potentiate the effect of metformin on hypothalamic-pituitary-thyroid axis activity.
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Authors | Robert Krysiak, Karolina Kowalcze, Monika Wolnowska, Bogusław Okopień |
Journal | Journal of clinical pharmacy and therapeutics
(J Clin Pharm Ther)
Vol. 45
Issue 5
Pg. 937-945
(Oct 2020)
ISSN: 1365-2710 [Electronic] England |
PMID | 31903641
(Publication Type: Journal Article)
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Copyright | © 2019 John Wiley & Sons Ltd. |
Chemical References |
- Contraceptives, Oral, Hormonal
- Hypoglycemic Agents
- Insulin
- Thyroid Hormones
- Metformin
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Topics |
- Adult
- Case-Control Studies
- Contraceptives, Oral, Hormonal
(administration & dosage, pharmacology)
- Diabetes Mellitus, Type 2
(drug therapy)
- Drug Interactions
- Female
- Humans
- Hypoglycemic Agents
(administration & dosage, pharmacology)
- Hypothalamo-Hypophyseal System
(drug effects, metabolism)
- Insulin
(metabolism)
- Insulin Resistance
- Metformin
(administration & dosage, pharmacology)
- Middle Aged
- Pilot Projects
- Prediabetic State
(drug therapy)
- Thyroid Function Tests
- Thyroid Gland
(drug effects, metabolism)
- Thyroid Hormones
(metabolism)
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