HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Estradiol (Estrace)

Generally refers to the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the PLACENTA. It is also produced by the adipose tissue of men and postmenopausal women. The 17-alpha-isomer of estradiol binds weakly to estrogen receptors (RECEPTORS, ESTROGEN) and exhibits little estrogenic activity in estrogen-responsive tissues. Various isomers can be synthesized.

Also Known As:

Estrace; Oestradiol; 17 beta-Oestradiol; Aerodiol; Estraderm TTS; Estradiol Hemihydrate; Estradiol Hemihydrate, (17 alpha)-Isomer; Estradiol Monohydrate; Estradiol, (+-)-Isomer; Estradiol, (-)-Isomer; Estradiol, (16 alpha,17 alpha)-Isomer; Estradiol, (16 alpha,17 beta)-Isomer; Estradiol, (17-alpha)-Isomer; Estradiol, (8 alpha,17 beta)-(+-)-Isomer; Estradiol, (8 alpha,17 beta)-Isomer; Estradiol, (9 beta,17 alpha)-Isomer; Estradiol, (9 beta,17 beta)-Isomer; Estradiol, Monosodium Salt; Estradiol, Sodium Salt; Estradiol-17 alpha; Estradiol-17beta; Novartis Pharmaceuticals Brand of Estradiol; Orion Brand of Estradiol; Ovocyclin; Vivelle; 17 beta Estradiol; 17 beta Oestradiol; Estradiol 17 alpha; Estradiol 17 beta; Estradiol 17beta; Estradiol Orion Brand; 17 beta-Estradiol; Estradiol-17 beta; Estra-1,3,5(10)-triene-3,17-diol (17beta)-

Networked: 10364 relevant articles (363 outcomes, 1195 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Stanczyk, Frank Z: 27 articles (10/2015 - 01/2003)
2.	Hankinson, Susan E: 25 articles (10/2014 - 11/2002)
3.	Dowsett, Mitch: 24 articles (02/2016 - 01/2005)
4.	Mueck, A O: 24 articles (06/2012 - 07/2000)
5.	Seeger, H: 23 articles (06/2012 - 07/2000)
6.	Ylikorkala, Olavi: 20 articles (10/2015 - 01/2004)
7.	Etgen, Anne M: 20 articles (09/2013 - 09/2003)
8.	Santen, Richard J: 19 articles (07/2015 - 02/2002)
9.	Suzuki, Takashi: 18 articles (01/2015 - 05/2003)
10.	Sasano, Hironobu: 18 articles (05/2013 - 05/2003)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2005 - "Disease-free premenopausal controls had a significantly higher physical activity index (PAI) (p</=0.05), however, significantly higher weight (p</=0.05), body mass index (BMI) (p=0.01), waist (p</=0.005) and hip (p</=0.05) circumferences, waist:hip ratios (p</=0.05), and serum total estradiol levels (p<0.0005) were observed in cancer cases. " 11/01/1988 - "Since the alpha-isomer of busramustine was effective against both tumor lines, the mode of action of 17 beta-busramustine may not be related to estrogenic action by estradiol released from the maternal compound. " 02/01/1983 - "parvum before i.v. tumor challenge markedly inhibited the development of lung tumor colonies in normal recipients, but it was less effective in beta-estradiol-treated mice. " 02/01/2003 - "Novel insights into the non-nuclear estradiol response and its impact on the efficacy of antitumoral drugs observed in endometrial tumor cells are reviewed." 01/01/2008 - "Overproduction of estradiol is helpful in the diagnosis of the tumor because of its numerous symptoms. "
2.	Breast Neoplasms (Breast Cancer) 06/01/1999 - "Recent prospective studies have shown that postmenopausal women who develop breast cancer have significantly greater prediagnostic serum concentrations of oestradiol than postmenopausal women who remain healthy. " 07/01/1985 - "Oestradiol is effective in stimulating 3H-thymidine incorporation but not on proliferation of breast cancer cultured cells." 05/05/2009 - "Phyto-oestrogens are plant compounds structurally similar to oestradiol, which have been proposed to have protective effects against breast cancer. " 09/01/1998 - "These studies are the first to raise the possibility that gene delivery to breast tumor cells can be improved by estradiol in single- or repeated-treatment regimens." 01/01/2014 - "Parity and short-term estradiol treatment utilizes similar cellular mechanisms to confer protection against breast cancer."
3.	Hemorrhage 03/01/1999 - "The reduction in bleeding episodes associated with regimens with lower estradiol doses may lead to improved long-term therapy compliance by menopausal women. " 02/01/2006 - "The present studies were therefore designed to determine whether the ability to restore plasma protein and blood volume after hemorrhage is augmented during pregnancy and by chronically elevated estradiol levels. " 10/01/1996 - "The aim of this study was to investigate whether the 6 week application of a patch which released 100 micrograms/day oestradiol would reduce the number of abnormal bleeding days or eliminate the problem. " 03/01/1987 - "In a double blind trial of 90 women with three types of IUD (MLCu250; MLCu250 + 0.3 mg estradiol releasing about 1 microgram per day; and MLCu250 + 1.0 mg estradiol releasing about 3 micrograms per day) no difference in intensity or duration of bleeding was found." 06/01/1986 - "In a prospective, double-blind, randomized, cross-over trial, the effects of oral oestradiol, 2 mg daily, on the endometrial histology, frequency and severity of vaginal bleeding, and the symptomatic and psychological status of postmenopausal women were compared with those of oral oestradiol, 2 mg daily, plus oestriol, 1 mg daily. "
4.	Ischemia 02/01/2009 - "At 3 and 4 weeks after induction of hind-limb ischemia, perfusion was significantly greater (p<0.05) in high-dose estradiol mice than in mice implanted with the low-dose estradiol or placebo pellets. " 09/24/2015 - "To our knowledge, our results are the first to demonstrate that estradiol at near physiological concentrations enhances basal excitatory synaptic transmission and ameliorates deficits in LTP at synapses onto CA1 neurons in a clinically-relevant model of global ischemia. " 09/24/2015 - "Estradiol pretreatment ameliorates impaired synaptic plasticity at synapses of insulted CA1 neurons after transient global ischemia." 03/19/2010 - "Exogenous estradiol ameliorates global ischemia-induced neuronal death and cognitive impairment in male and female rodents. " 03/01/2007 - "Exogenous estradiol ameliorates global ischemia-induced neuronal death and cognitive impairment in male and female rodents. "
5.	Osteoporosis 06/01/2008 - "After adjusting for age, years since menopause, and estradiol, women with osteoporosis had significantly greater carotid IMT than controls (p<0.05). " 07/30/1988 - "Subcutaneous oestrogen is more effective than oral oestrogen in preventing osteoporosis, probably owing to the more physiological (premenopausal) serum oestradiol concentrations achieved. " 06/01/1997 - "In addition, 17 beta-estradiol levels remained within the suggested therapeutic ranges for relief of acute symptoms and protection against osteoporosis for longer periods of time with Menorest 50 than with Systen 50. " 07/01/1992 - "Transdermal estradiol treatment is effective in postmenopausal women with established osteoporosis." 12/01/1999 - "The efficacy of osteoblasts to synthesize estradiol may determine the ultimate change in rate of bone turnover after menopause, as well as the development of osteoporosis. "

Related Drugs and Biologics

1.	Estrogens (Estrogen)
2.	Progesterone
3.	Testosterone (Sustanon)
4.	Hormones
5.	Tamoxifen
6.	Estrone (Folliculin)
7.	Prolactin
8.	Insulin (Novolin)
9.	Cyproterone Acetate
10.	Follicle Stimulating Hormone (Follitropin)

Related Therapies and Procedures

1.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
2.	Female Contraceptive Devices (Vaginal Ring)
3.	Ovariectomy (Oophorectomy)
4.	Estrogen Replacement Therapy
5.	Drug Therapy (Chemotherapy)