Abstract | RATIONALE: PATIENT CONCERNS: DIAGNOSIS: SFTS was diagnosed based on a positive serum test for SFTS virus RNA and electroencephalogram (EEG) findings of encephalopathy. INTERVENTIONS: OUTCOMES: Treatment for 7 days improved both symptoms and abnormal EEG findings, and SFTS virus RNA disappeared from the serum at day 10 from the onset of symptoms. The serum cytokines and chemokines analysis during the clinical course revealed 2 distinct phases: the acute phase and the recovery phase. The cytokines and chemokines elevated in the acute phase included interleukin (IL)-6, IL-10, interferon (IFN)-α2, IFN-γ, tumor necrosis factor-α, interferon-γ-induced protein-10, and fractalkine, while the IL-1β, IL-12p40, IL-17, and vascular endothelial growth factor levels were higher in the recovery phase. CONCLUSION: These observations suggest that the cytokines and chemokines elevated in the acute phase may reflect the disease severity resulted in a cytokine storm, while those in the recovery phase may be attributed to T-cell activation and differentiation.
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Authors | Keita Fujikawa, Tomohiro Koga, Takahide Honda, Toshihisa Uchida, Momoko Okamoto, Yushiro Endo, Tomo Mihara, Akira Kondo, Satoshi Shimada, Daisuke Hayasaka, Kouichi Morita, Akinari Mizokami, Atsushi Kawakami |
Journal | Medicine
(Medicine (Baltimore))
Vol. 98
Issue 42
Pg. e17571
(Oct 2019)
ISSN: 1536-5964 [Electronic] United States |
PMID | 31626125
(Publication Type: Case Reports, Journal Article, Review)
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Chemical References |
- Biomarkers
- Chemokines
- Cytokines
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Topics |
- Biomarkers
(blood)
- Chemokines
(blood)
- Cytokines
(blood)
- Female
- Fever
(blood, virology)
- Humans
- Middle Aged
- Phlebotomus Fever
(blood, virology)
- Phlebovirus
(physiology)
- Severity of Illness Index
- Syndrome
- Thrombocytopenia
(blood, virology)
- Viral Load
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