HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Disseminated Intravascular Coagulation

Subscribe to New Research on Disseminated Intravascular Coagulation

A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.

Also Known As:

Coagulation, Disseminated Intravascular; Disseminated Coagulation, Intravascular; Intravascular Coagulation, Disseminated; Intravascular Disseminated Coagulation; Coagulation, Intravascular Disseminated; Coagulations, Disseminated Intravascular; Coagulations, Intravascular Disseminated; Coagulopathies, Consumption; Coagulopathy, Consumption; Consumption Coagulopathies; Disseminated Coagulations, Intravascular; Disseminated Intravascular Coagulations; Intravascular Coagulations, Disseminated; Intravascular Disseminated Coagulations; Consumption Coagulopathy

Networked: 4602 relevant articles (132 outcomes, 212 trials/studies)

Relationship Network

Disease Context: Research Results

Hemic and Lymphatic Diseases
- Hematologic Diseases: 1962

Related Diseases

1.	Sepsis (Septicemia)
2.	Thrombosis (Thrombus)
3.	Hemorrhage
4.	Thrombocytopenia (Thrombopenia)
5.	Shock

Experts

1.	Wada, Hideo: 50 articles (02/2015 - 03/2002)
2.	Gando, Satoshi: 46 articles (05/2015 - 01/2003)
3.	Asakura, Hidesaku: 30 articles (08/2015 - 01/2002)
4.	Levi, Marcel: 24 articles (11/2014 - 01/2002)
5.	Nobori, Tsutomu: 24 articles (01/2013 - 03/2002)
6.	Kim, Hyun Kyung: 22 articles (01/2016 - 10/2002)
7.	Isbister, Geoffrey K: 21 articles (01/2016 - 01/2007)
8.	Okamoto, Kohji: 21 articles (01/2016 - 09/2003)
9.	Hayakawa, Mineji: 20 articles (02/2015 - 01/2003)
10.	Kim, Ji-Eun: 19 articles (01/2016 - 01/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Disseminated Intravascular Coagulation:

1.	Dacarbazine (DIC)FDA LinkGeneric 01/01/2000 - "First remission rates have increased to greater than 85% world wide, the incidence of disseminated intravascular coagulation (DIC) has declined dramatically, and 60% to 70% of patients with AML-M3 have achieved long term survival and are potentially cured." 01/01/1990 - "3) The patients with disseminated intravascular coagulation (DIC) showed statistically marked decrease of the XIIIa, the alpha 2PI, and the FN on admission and the first hospital day compared with those patients without DIC. " 01/01/1987 - "In the absence of good clinical trials, the value of ATIII replacement therapy also remains obscure; its use in congenital deficiency is largely based on anecdote, and while it may cause more rapid correction of the hemostatic defect in patients with disseminated intravascular coagulation (DIC), any improvement in morbidity or mortality resulting from ATIII replacement remains to be demonstrated." 07/03/1978 - "The reduced response of the platelets in the newborn to these aggregating agents can be considered as a protection against disseminated intravascular coagulation (DIC), particularly in high-risk situations." 06/01/2009 - "Although obstetric disease is one of the major causes of disseminated intravascular coagulation (DIC), no gold standard exists. "
2.	Heparin (Liquaemin)FDA LinkGeneric 04/01/1980 - "Since the assay system is unaffected by fibrino(geno)lytic degradation products and heparin, it proved useful in monitoring the efficacy of heparin therapy for disseminated intravascular coagulation. " 07/01/1976 - "Disseminated intravascular coagulation caused by the carpet viper (Echis carinatus): trial of heparin." 01/01/2009 - "A 54-year-old woman was transferred to our hospital with disseminated intravascular coagulation, and was treated with heparin. " 01/01/2007 - "Anti-heparin/PF4 complexes by ELISA in patients with disseminated intravascular coagulation." 12/01/1999 - "In addition to treatment of the underlying disease, consumption coagulopathy was previously treated with heparin. "
3.	Antithrombin IIIIBA 01/01/1998 - "Antithrombin III (AT III) supplementation has proven to be effective in the treatment of disseminated intravascular coagulation. " 06/01/1988 - "Efficacy of antithrombin III in endotoxin-induced disseminated intravascular coagulation." 01/01/1987 - "Protection against disseminated intravascular coagulation and death by antithrombin-III in the Escherichia coli endotoxemic rat." 08/01/2007 - "Differences in antithrombin III activities by administration method in critical patients with disseminated intravascular coagulation: a pharmacokinetic study." 12/01/2014 - "Impact of withdrawing antithrombin III administration from management of septic patients with or without disseminated intravascular coagulation."
4.	ThrombomodulinIBA 01/01/2015 - "The efficacy of recombinant human soluble thrombomodulin for obstetric disseminated intravascular coagulation: a retrospective study." 02/01/2015 - "Observational study to compare antithrombin and thrombomodulin for disseminated intravascular coagulation." 04/01/2011 - "Thrombomodulin alfa in the treatment of infectious patients complicated by disseminated intravascular coagulation: subanalysis from the phase 3 trial." 08/01/2015 - "Recombinant soluble thrombomodulin for postoperative disseminated intravascular coagulation." 01/01/2015 - "Recombinant human soluble thrombomodulin (rhTM) is a new drug for the treatment of disseminated intravascular coagulation in Japan. "
5.	Fibrinogen (Factor I)FDA Link 07/01/2006 - "Prolonged prothrombin time, 26 seconds (normal range 13-16 seconds); prolonged activated partial thromboplastin time, 61 seconds (normal range 26-38 seconds); positive disseminated intravascular coagulation studies evidenced by low fibrinogen, 74 mg/dL (normal range 160-350 mg/dL); and positive fibrinogen degradation products were also noted. " 07/01/1982 - "[Studies on fibrinogen heterogeneity in disseminated intravascular coagulation]." 04/21/2012 - "Fibrinogen assays are commonly used as part of clinical screening tests to investigate haemorrhagic states, for detection of disseminated intravascular coagulation and as a predictor of a variety of cardiovascular events. " 11/01/2009 - "Second, we noted an extremely low fibrinogen level in the presence of normal platelet count and only a slight increase of D-dimers (absence of important disseminated intravascular coagulation). " 05/01/2003 - "Although the pro-files of soluble FM-fibrinogen complex in individual patients appeared to vary from one patient to the other, the plasma level of soluble FM-fibrinogen complex was found to be increased at the initial phase of disseminated intravascular coagulation syndrome. "
6.	Thromboplastin (Tissue Factor)IBA 01/01/2014 - "Although tissue factor-mediated and NET-mediated immunothrombosis plays a role in early host defense against bacterial dissemination, uncontrolled immunothrombosis may lead to disseminated intravascular coagulation. " 06/01/2011 - "Tissue factor as a target for the treatment of disseminated intravascular coagulation." 04/01/2008 - "Additionally, one should exercise caution if there is evidence of activated coagulation, such as that seen with excessive tissue factor release or disseminated intravascular coagulation. " 01/01/2002 - "Because pathophysiology differed remarkably between the tissue factor- and lipopolysaccharide-induced disseminated intravascular coagulation models in rats, we recommend that they be assessed carefully as distinct entities to determine implications of their experimental and clinical use." 01/01/2002 - "Tissue factor and lipopolysaccharide frequently have been used to induce disseminated intravascular coagulation in experimental animal models. "
7.	Protease Inhibitors (Protease Inhibitor)IBA 03/01/2013 - "We identified patients undergoing URSL from the Japanese Diagnosis Procedure Combination database between 2007 and 2010, and defined severe adverse events as (i) in-hospital mortality; (ii) postoperative medication including catecholamine, γ globulin, protease inhibitors, medications for disseminated intravascular coagulation and transfusion; and (iii) postoperative interventions including percutaneous nephrostomy, central vein catheterisation, intensive care unit, dialysis, mechanical cardiopulmonary support. " 05/01/2000 - "Is protease inhibitor a choice for the treatment of pre- or mild disseminated intravascular coagulation?" 01/01/1993 - "[Synthetic protease inhibitors in the treatment of disseminated intravascular coagulation]." 10/15/1989 - "In other diseases, especially in a patient with disseminated intravascular coagulation, a somewhat higher amount of large multimers were found in plasma with protease inhibitors than without inhibitors. " 01/01/1991 - "[The protease inhibitor treatment of the disseminated intravascular coagulation syndrome in patients with liver cirrhosis]."
8.	Tretinoin (Retinoic Acid)FDA LinkGeneric 08/01/2013 - "Neither disseminated intravascular coagulation nor retinoic acid syndrome was observed during the course of her illness. " 01/01/2001 - "Some experiments were also done to determine whether all-trans retinoic acid would ameliorate the signs of the endotoxin-induced disseminated intravascular coagulation. " 11/27/2001 - "This patient received treatment with retinoic acid and chemotherapy, but developed a disseminated intravascular coagulation and died before completing therapy. " 05/01/2008 - "Administration of all trans-retinoic acid improved disseminated intravascular coagulation without decrease of the leukemia cells in his peripheral blood and bone marrow. " 11/01/1997 - "Early diagnosis of t(15;17) acute promyelocytic leukemia (APL) is essential because of the associated disseminated intravascular coagulation and the unique response of the disease to all-trans retinoic acid (ATRA) therapy. "
9.	Protein CIBA 07/01/1985 - "Serial studies of protein C and its plasma inhibitor in patients with disseminated intravascular coagulation." 11/01/2014 - "Differential expression of leukocyte receptors in disseminated intravascular coagulation: prognostic value of low protein C receptor expression." 11/01/2004 - "The presence or absence of disseminated intravascular coagulation should not influence the decision to administer recombinant human activated protein C. " 10/01/2004 - "[Blood plasma resistance to activated protein C as a risk factor of disseminated intravascular coagulation in acute-poisoned patients]." 06/15/2003 - "Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein-C-deficient mice."
10.	Gabexate (Foy)IBA 09/01/2012 - "Effects of antithrombin and gabexate mesilate on disseminated intravascular coagulation: a preliminary study." 11/01/1993 - "Treatment of disseminated intravascular coagulation with gabexate mesilate." 06/01/1988 - "Gabexate as a therapy for disseminated intravascular coagulation." 12/01/1986 - "[Treatment of pre-disseminated intravascular coagulation state with gabexate mesilate (FOY)]." 01/01/1983 - "Protective effect of gabexate mesilate against experimental disseminated intravascular coagulation in rats."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 12/01/1983 - "Inspite of chemotherapy one twin died of disseminated intravascular coagulation with pulmonary haemorrhage; the other one, however, went into long-term remission. " 01/01/2006 - "Thirty-seven (69%) patients received chemotherapy because of extensive disease with organ involvement (54%), extensive disease without organ involvement (19%), severe disseminated intravascular coagulation (11%), and other reasons (16%). " 01/01/2004 - "One patient died 8 months after first admission to our hospital, another died of disseminated intravascular coagulation I month after admission, and the third was treated with hepatic arterial infusion chemotherapy and survived >36 months. " 09/01/2001 - "Patient died of complications of malignancy-related disseminated intravascular coagulation without chemotherapy after confirming diagnosis was made three months later." 01/01/1997 - "Despite the conventional chemotherapy and ATRA therapy she died from disseminated intravascular coagulation during her third relapse. "
2.	Intravenous Infusions 01/01/1972 - "A trial to produce disseminated intravascular coagulation with intravenous infusion of homologous haemolysate and serum in cats." 11/03/1978 - "Disseminated intravascular coagulation occurred in two patients during a trial intravenous infusion of ascites and occurred in one patient even when the surgical procedure was modified to minimize the volume and rate of the infused ascites." 12/01/1972 - "Intravenous infusions of Iysates of 232 x 10(6) rabbit leukocytes which had been incubated in cultures at 37 C for 24 hours produced disseminated intravascular coagulation and vasculitis involving the pulmonary arteries in normal rabbits. " 05/01/1977 - "The case of a two-month -old female infant, who after a severe diarrhoea treated with prolonged intravenous infusion in peripheral veins alternated with total parenteral feeding, developed a Candida albicans septicemia (accompanied by disseminated intravascular coagulation syndrome) is reported. " 11/01/2000 - "In rat disseminated intravascular coagulation (DIC) models, intravenous infusion of MR-33 improved the hematological abnormalities without excessive prolongation of APTT and bleeding time. "
3.	Combination Drug Therapy (Combination Chemotherapy) 01/01/2014 - "Disseminated intravascular coagulation secondary to advanced pancreatic cancer treated successfully with combination chemotherapy." 09/01/1981 - "[Disseminated intravascular coagulation after polychemotherapy of proliferative hematologic diseases]." 01/01/2002 - "We concluded that disseminated intravascular coagulation caused by gastric cancer may be improved when the primary cancer and its metastases are brought under control by treatment with FP combination chemotherapy." 11/01/2012 - "[A case of advanced gastric cancer with multiple bone metastases and disseminated intravascular coagulation successfully treated by combination chemotherapy of S-1 plus docetaxel]." 03/01/2009 - "Although we next started carboplatin and paclitaxel combination chemotherapy, she died due to rapidly progression of the disease with disseminated intravascular coagulation after 132 days of the operation. "
4.	Ligation 04/01/1993 - "However, this activity decreased significantly after portal vein ligation, suggesting progression into irreversible disseminated intravascular coagulation. " 02/01/1997 - "Function was lost to occlusion in 26 patients, infection in 9, and ligation for disseminated intravascular coagulation in 3. Thirteen patients underwent 18 shunt replacements. " 03/01/1993 - "These included interruption of collateral vessels, intraoperative hypotension and disseminated intravascular coagulation, and distal splenic artery ligation. " 02/01/1989 - "The procedure was successful in arresting the haemorrhage in 13 patients but 4 needed hysterectomy in spite of the ligation; 1 patient died from disseminated intravascular coagulation following surgery and 1 had cardiac arrest due to extensive blood loss during surgery and died 12 hours later. " 09/01/1987 - "Deaths resulted from disseminated intravascular coagulation and bleeding, and bleeding and pulmonary failure after ligation of a patent ductus arteriosus. "
5.	Thrombolytic Therapy 10/01/1978 - "[Thrombolytic therapy of consumption coagulopathy]." 12/12/1975 - "The coagulation tests showed signs of disseminated intravascular coagulation and so the child was given fibrinolytic therapy for 36 hours following initial heparinization. " 03/30/1974 - "Letter: Thrombolytic therapy of the anuric stage of disseminated intravascular coagulation." 09/01/2014 - "We postulated that thrombolytic therapy for cancer-related NBTE might easily cause hemorrhagic complications because cancer-related NBTE is often similar to the state of disseminated intravascular coagulation. " 06/01/2014 - "She was treated with thrombolytic therapy and suffered a massive hemorrhage thereafter, which was compounded by disseminated intravascular coagulation. "