Taurine-magnesium coordination compound, a potential anti-arrhythmic complex, improves aconitine-induced arrhythmias through regulation of multiple ion channels.

Abstract

Taurine-magnesium coordination compound (TMCC) exhibits antiarrhythmic effects in cesium-chloride-and ouabain-induced arrhythmias; however, the mechanism underlying these effects on arrhythmia remains poorly understood. Here, we investigated the effects of TMCC on aconitine-induced arrhythmia in vivo and the electrophysiological effects of this compound in rat ventricular myocytes in vitro. Aconitine was used to induce arrhythmias in rats, and the dosages required to produce ventricular premature contraction (VPC), ventricular tachycardia (VT), ventricular fibrillation (VF), and cardiac arrest (CA) were recorded. Additionally, the sodium current (INa) and L-type calcium current (ICa,L) were analyzed in normal and aconitine-treated ventricular myocytes using whole-cell patch-clamp recording. In vivo, intravenous administration of TMCC produced marked antiarrhythmic effects, as indicated by the increased dose of aconitine required to induce VPC, VT, VF, and CA. Moreover, this effect was abolished by administration of sodium channel opener veratridine and calcium channel agonist Bay K8644. In vitro, TMCC inhibited aconitine-induced increases in INa and ICa,L. These results revealed that TMCC inhibited aconitine-induced arrhythmias through effects on INa and ICa,L.

• Authors: Jianshi Lou, Hong Wu, Lingfang Wang, Lin Zhao, Xin Li, Yi Kang, Ke Wen, Yongqiang Yin
• Journal: Toxicology and applied pharmacology (Toxicol Appl Pharmacol) Vol. 356 Pg. 182-190 (10 01 2018) ISSN: 1096-0333 [Electronic] United States
• PMID: 30125596 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2018 Elsevier Inc. All rights reserved.

Chemical References

• Anti-Arrhythmia Agents
• Calcium Channels, L-Type
• Ion Channels
• Magnesium Compounds
• Sodium Channels
• Taurine
• Aconitine

Topics

• Aconitine
• Animals
• Anti-Arrhythmia Agents (therapeutic use)
• Arrhythmias, Cardiac (chemically induced, drug therapy)
• Calcium Channels, L-Type (drug effects)
• Electrophysiological Phenomena (drug effects)
• Female
• Heart Arrest (chemically induced, prevention & control)
• Heart Ventricles (cytology, drug effects)
• Ion Channels (drug effects)
• Magnesium Compounds (therapeutic use)
• Male
• Myocytes, Cardiac (drug effects)
• Patch-Clamp Techniques
• Rats
• Rats, Wistar
• Sodium Channels (drug effects)
• Taurine (therapeutic use)