Ion Channels (Ion Channel)

Gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS.

Also Known As:

Networked: 3653 relevant articles (66 outcomes, 278 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mohler, Peter J: 18 articles (01/2015 - 02/2003)
2.	Nattel, Stanley: 17 articles (08/2015 - 08/2003)
3.	Ackerman, Michael J: 14 articles (04/2013 - 01/2005)
4.	Shimizu, Wataru: 13 articles (03/2014 - 02/2002)
5.	Arcangeli, Annarosa: 12 articles (10/2015 - 01/2004)
6.	Peers, Chris: 12 articles (02/2015 - 07/2002)
7.	Waxman, Stephen G: 11 articles (05/2015 - 09/2002)
8.	Bunnett, Nigel W: 10 articles (11/2015 - 10/2006)
9.	Zareba, Wojciech: 10 articles (10/2015 - 01/2002)
10.	Berkovic, Samuel F: 10 articles (06/2010 - 09/2002)

Related Diseases

1.	Pain (Aches) 07/01/2004 - "The heat-activated ion channels (TRPV1-4) are thought to play a significant role in inflammatory pain which is effectively relieved by cooling. " 01/01/2006 - "Improved efficacy of ion channel modulators hinges upon further elucidation of the relationship between signs and symptoms of pain and underlying pathophysiology." 04/01/2014 - "Therefore, studies of ion channels in pain pathways are extremely active. " 03/01/2014 - "The study explores the role of acid-sensitive ion channel 3 (ASIC3) in the cerebrospinal fluid (CSF)-contacting nucleus of the parenchyma of rat brain, in inflammatory pain. " 12/01/2013 - "Genetic studies have identified several associations between ion channels and OA pain, including NaV1.7, P2X7, and TRPV1, but several other channels have also been implicated. "
2.	Atrial Fibrillation 08/01/2008 - "This article focuses on novel aspects of altered atrial repolarisation and discusses atrium-selective (I(Kur), I(K,ACh)) and pathology-specific (I(K,ACh)) ion channels as potential targets for safe and effective treatment of atrial fibrillation." 04/01/2007 - "Elucidating the signalling pathways responsible for the process of structural atrial remodeling has helped to define novel non-ion channel drug targets for atrial fibrillation." 01/01/2012 - "Cardiac ion channels and mechanisms for protection against atrial fibrillation." 04/01/2010 - "Recent studies of atrial fibrillation (AF) have identified mutations in a series of ion channels; however, these mutations appear to be relatively rare causes of AF. " 10/01/2015 - "Ion Channel Mutations and Lone Atrial Fibrillation."
3.	Human Influenza (Influenza) 10/01/2005 - "In this study, four possible conformations of the His-37 and Trp-41 residues for the closed state of the influenza M2 ion channel were identified by a conformation scan based on a solid-state NMR restraint. " 09/01/2015 - "We report the potential of the influenza M2 ion channel as a novel tool to neutralize the pH in acidic subcellular compartments. " 08/01/2013 - "Conjugation to polymeric chains of influenza drugs targeting M2 ion channels partially restores inhibition of drug-resistant mutants." 05/01/2013 - "Influenza matrix protein 2 alters CFTR expression and function through its ion channel activity." 11/01/2012 - "The adamantanes are a class of anti-influenza drugs that inhibit the M2 ion channel of the influenza A virus. "
4.	Epilepsy (Aura) 10/01/2010 - "A better understanding of the key ion channels and brain regions that are responsible for the development of this hyperexcitability, along with the molecular mechanisms involved, may provide novel treatment strategies for epilepsy." 09/01/2014 - "Additional evidence for a role of CLCN1 in the pathogenesis of epilepsy is derived from large-scale exome analysis of ion channel variants and expression studies. " 01/01/2012 - "To solve these problems, the study of genetic epilepsies caused by mutant ion channels presents special advantages, as it can exploit the full range of modern experimental methods. " 01/01/2012 - "Fine mapping study defined a ∼1 Mb region including 12 genes of which none are known epilepsy genes or encode ion channels. " 05/01/2009 - "Studies of pathological ion channel regulation as an underlying mechanism of epilepsy have revealed alterations in the h-current in several animal models. "
5.	Cardiac Arrhythmias (Arrythmia) 11/01/2011 - "The identification and analysis of several cationic ion channels and their associated genes have greatly improved our understanding of the molecular and cellular mechanisms of cardiac arrhythmia. " 01/01/2014 - "Molecular genetic studies in the last 2 decades have revealed a link between several inherited cardiac arrhythmias and genes encoding for ion channels or other membrane components. " 11/01/2011 - "Our objective in this study was to examine the involvement of anionic ion channels in cardiac arrhythmia. " 11/01/2011 - "Our previous studies suggest a role for arrhythmia-related ion channel genes in the pathogenesis of SUDEP. " 11/01/2010 - "Molecular genetic studies have established a link between a number of inherited cardiac arrhythmia syndromes and mutations in genes encoding cardiac ion channels or membrane components during the past 2 decades. "

Related Drugs and Biologics

1.	Anti-Arrhythmia Agents
2.	Neuraminidase (Sialidase)
3.	Rimantadine
4.	Neurotransmitter Agents (Neurotransmitter)
5.	Amantadine (Aman)
6.	Anticonvulsants (Antiepileptic Drugs)
7.	Calcium
8.	Ion Channels (Ion Channel)
9.	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)
10.	Bepridil (Vascor)

Related Therapies and Procedures

1.	Chemoprevention
2.	Ligation
3.	Therapeutics
4.	Drug Therapy (Chemotherapy)
5.	Lasers (Laser)