Calcium Channel Agonists

Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in VASCULAR SMOOTH MUSCLE and/or CARDIAC MUSCLE cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture.

Also Known As:

Networked: 36 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Meriney, Stephen D: 2 articles (06/2013 - 12/2012)
2.	Liang, Mary: 2 articles (06/2013 - 12/2012)
3.	Valdomir, Guillermo: 2 articles (06/2013 - 12/2012)
4.	Tarr, Tyler B: 2 articles (06/2013 - 12/2012)
5.	Wipf, Peter: 2 articles (06/2013 - 12/2012)
6.	Malick, Waqas: 1 article (06/2013)
7.	Frasso, Michael: 1 article (06/2013)
8.	Garcia-Ocano, Adolfo: 1 article (06/2013)
9.	Lacomis, David: 1 article (06/2013)
10.	Reddel, Stephen W: 1 article (06/2013)

Related Diseases

1.	Ischemia 06/01/1988 - "In contrast, Bay K 8644 (10(-7) M), a calcium-channel agonist, exacerbated ischemia-induced conduction slowing and depression of Vmax but did not significantly affect resting membrane potential. " 01/01/1995 - "We investigated the effect of ischemia and reperfusion on the contractile response of canine renal and iliac arteries to the dihydropyridine-type calcium channel agonist (+/-)Bay K 8644, following subthreshold doses of ET-1. " 01/01/2010 - "In the present study the roles of calcium and G protein in contraction induced by angiotensin II (agonist of the metabotropic receptor AT1), phenylephrine (agonist of alpha1-adrenergic metabotropic receptor), and Bay K8644 (a calcium channel agonist) after ischemia/reperfusion were investigated. "
2.	Hypertension (High Blood Pressure) 04/01/1988 - "In conclusion, the DS kidney vasculature manifests an increase in responsiveness to this calcium channel agonist, independently of antecedent NaCl loading or high blood pressure. " 10/05/1988 - "Dihydropyridine calcium channel agonists and antagonists elicit exaggerated glomerular and circulatory responses from kidneys isolated from Dahl rats genetically programmed to develop NaCl-induced hypertension (Dahl S rats). " 10/05/1988 - "In contrast, "chemical sympathectomy" with 6-hydroxydopamine enhances renal vascular responses to calcium channel agonists in a manner that depends on the antecedent dietary NaCl intake, and is independent of genetic predilection to develop NaCl-induced hypertension. " 09/01/1994 - "The present study evaluates the response to the L-type voltage gated calcium channel agonist Bay K 8644 in two forms of experimental hypertension (mineralocorticoid- and hypertension induced by the nitric oxide synthase inhibitor N omega-nitro-L-arginine (N-Nitro arginine)) and under conditions of acute stretch. "
3.	Sleep Deprivation 09/01/2012 - "Therapeutic trials for treatment-resistant bipolar depression have assessed anticonvulsants, modern antipsychotics, glutamate [N-methyl-D-aspartate (NMDA)] antagonists, dopamine agonists, calcium-channel blockers, and thyroid hormones, as well as behavioral therapy, sleep deprivation, light therapy, electroconvulsive therapy (ECT), transcranial magnetic stimulation, and deep brain stimulation-all of which are promising but limited in effectiveness. "
4.	Heart Failure 01/01/2004 - "The novel *NO donor (-)-(S,R)-1-methyl-2-nitrooxyethyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2,1,3-benzoxadiazol-4-yl)pyridine-5-carboxylate [(-)-(S,R)-38], which acts as a dual cardioselective calcium channel agonist (GPLA)/smooth muscle selective calciumchannel antagonist (GPILSM), is a useful lead compound for drug discovery targeted to the treatment of congestive heart failure, and it provides a useful research probe to study the structure-function relationship of calcium channels."
5.	Bipolar Disorder (Mania) 09/01/2012 - "Therapeutic trials for treatment-resistant bipolar depression have assessed anticonvulsants, modern antipsychotics, glutamate [N-methyl-D-aspartate (NMDA)] antagonists, dopamine agonists, calcium-channel blockers, and thyroid hormones, as well as behavioral therapy, sleep deprivation, light therapy, electroconvulsive therapy (ECT), transcranial magnetic stimulation, and deep brain stimulation-all of which are promising but limited in effectiveness. "

Related Drugs and Biologics

1.	Methyl ester 1,4- dihydro- 2,6- dimethyl- 5- nitro- 4- (2- (trifluoromethyl)phenyl)- 3-Pyridinecarboxylic acid
2.	Calcium
3.	Calcium Channels (Calcium Channel)
4.	N-Methylaspartate (NMDA)
5.	GTP-Binding Proteins (G-Protein)
6.	Angiotensin II
7.	Nitroarginine (NG Nitro L Arginine)
8.	Nitric Oxide Synthase (NO Synthase)
9.	Glutamic Acid (Glutamate)
10.	Dopamine Antagonists

Related Therapies and Procedures

1.	Deep Brain Stimulation
2.	Phototherapy (Light Therapy)
3.	Therapeutics
4.	Chemical Sympathectomy
5.	Bed Rest (Bedrest)