Anti-Arrhythmia Agents

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.

Also Known As:

Networked: 1964 relevant articles (175 outcomes, 241 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Natale, Andrea: 22 articles (09/2015 - 09/2002)
2.	Crijns, Harry J G M: 15 articles (12/2014 - 08/2002)
3.	Van Gelder, Isabelle C: 13 articles (06/2014 - 08/2002)
4.	Jaïs, Pierre: 12 articles (06/2014 - 01/2003)
5.	Haïssaguerre, Michel: 11 articles (06/2014 - 01/2003)
6.	Di Biase, Luigi: 10 articles (09/2014 - 10/2008)
7.	Hocini, Mélèze: 10 articles (06/2014 - 01/2003)
8.	Nattel, Stanley: 9 articles (12/2015 - 10/2003)
9.	Lip, Gregory Y H: 9 articles (05/2014 - 07/2004)
10.	Verma, Atul: 9 articles (02/2014 - 05/2004)

Related Diseases

1.	Atrial Fibrillation 04/01/2006 - "Because presently available antiarrhythmic drugs are neither as highly efficacious nor as safe as desirable for the prevention of atrial fibrillation (AF), rate control-versus-rhythm control trials for the treatment of AF were evaluated. " 07/01/2013 - "Antiarrhythmic drugs (AADs) are often used after ablation for atrial fibrillation (AF); the drugs employed vary, but most common are the drugs that were unsuccessful prior to ablation since it seems that the efficacy of AADs might substantially increase after catheter ablation of AF. " 06/01/2013 - "Major challenges in atrial fibrillation management include selecting patients most likely to benefit from rhythm control, choosing specific antiarrhythmic drugs or procedures to achieve rhythm control, long-term monitoring to gauge the efficacy of rhythm control, and determining which (if any) patients may safely discontinue anticoagulation if long-term NSR is achieved." 04/01/2007 - "The convenience to count with a safe and effective pharmacological wealth for atrial fibrillation treatment had conduced, in a way, to a deep depuration of the vast array of antiarrhythmic drugs, keeping only a very restricted number of compounds with a widely proved anti-atrial activity. " 07/01/1999 - "Antiarrhythmic drugs remain the mainstay of treatment of atrial fibrillation, but their potential proarrhythmic effects hamper their optimal use. "
2.	Cardiac Arrhythmias (Arrythmia) 01/01/1989 - "The type of antiarrhythmic drugs to be used is discussed, considering that, while many traditional antiarrhythmic agents are undoubtedly effective in the treatment of an acute arrhythmia, in the chronic setting, most of the time, a significant reduction in ventricular arrhythmias on Holter monitoring can be proved, without a significant reduction in total mortality. " 10/01/1999 - "These are mainly related to the use of antiarrhythmic drugs, the efficacy of which is not very great and may present a potential risk of lethal pro-arrhythmia or severe collateral effects. " 04/01/1987 - "The combination of improved diagnostic techniques, new and potent antiarrhythmia agents, and progress in antiarrhythmia surgical procedures has resulted in successful management of complex cardiac arrhythmia in children. " 12/01/1985 - "Subgroups IA, IB and ID were characterised by the absence of symptoms, the disappearance of the arrhythmia on exercise, the decreased efficacy of antiarrhythmic drugs and an excellent prognosis. " 04/01/1999 - "Analyses of randomised clinical trials have suggested that only in selective populations may antiarrhythmic drugs be effective in improving prognosis: therapy of cardiac arrhythmias, in contrast to other cardiovascular pathological conditions, has not been fully successful. "
3.	Ventricular Tachycardia 05/01/2010 - "The efficacy of antiarrhythmic drugs in terminating sustained monomorphic ventricular tachycardia (SMVT) was assessed in a retrospective manner to provide a basis for recommending their use. " 07/02/1994 - "The efficacy of antiarrhythmic drugs for terminating sustained ventricular tachycardia (VT) has been disappointing. " 07/01/1998 - "Clinical findings, such as the inducibility of ventricular tachycardia by stress or catecholamine infusion, and the therapeutic efficacy of antiarrhythmic drugs with antiadrenergic properties suggest abnormalities of cardiac sympathetic innervation in patients with idiopathic RVO-VT. " 07/01/1989 - "Previously ineffective antiarrhythmic drugs were effective in preventing the induction of ventricular tachycardia in four of these eight patients. " 11/03/1988 - "Programmed stimulation (PES) and ambulatory electrocardiographic (Holter) monitoring are both widely used to evaluate the efficacy of antiarrhythmic drugs in patients with recurrent ventricular tachycardia (VT). "
4.	Tachycardia (Tachyarrhythmias) 06/01/1987 - "It can be administered safely to patients with sustained ventricular tachyarrhythmias and is as effective as approved antiarrhythmic drugs when assessed by electropharmacologic testing." 09/01/1993 - "Many new antiarrhythmic drugs effective in supraventricular tachyarrhythmia are now available. " 07/01/2001 - "TWA may also be a useful marker for evaluating the efficacy of antiarrhythmic drugs for ventricular tachyarrhythmias." 01/01/1993 - "In principle, all antiarrhythmic drugs (classes 1-3) are useful in the treatment of ventricular tachyarrhythmias. " 01/01/2007 - "In 44 patients (3 women and 41 men, mean age 54 +/- 11 years) with malignant ventricular tachyarrhythmias (MVT) we assessed dependence of results of testing of antiarrhythmic drugs and efficacy of their long term use for prevention of recurrences of MVT on topography of derangement of local left ventricular (LV) contractility. "
5.	Ventricular Fibrillation 02/17/2009 - "Our purpose was to evaluate the efficacy of antiarrhythmic drugs (AADs) in recurrent ventricular fibrillation (VF) associated with inferolateral early repolarization pattern on the electrocardiogram. " 02/01/1997 - "1. In the last decade, a number of clinical observations have questioned the efficacy of certain class I antiarrhythmic drugs against ischaemia-induced ventricular fibrillation. " 01/01/2004 - "Thus, in recent years, studies have focused on the roles played by specific ionic mechanisms and their modulation by antiarrhythmic drugs in ventricular fibrillation dynamics. " 08/04/1988 - "Four of 13 patients (31 percent) who underwent multiple trials of antiarrhythmic drugs had recurrent episodes of ventricular fibrillation. " 03/01/1988 - "The purpose of this study was to compare the effects of several different antiarrhythmic drugs on the ventricular fibrillation threshold (VFT). "

Related Drugs and Biologics

1.	Amiodarone (Amiodarona)
2.	Ion Channels (Ion Channel)
3.	Flecainide (Tambocor)
4.	Lidocaine (Xylocaine)
5.	Sotalol (Sotalol Hydrochloride)
6.	Disopyramide (Norpace)
7.	Calcium
8.	Encainide
9.	Quinidine (Chinidin)
10.	Bepridil (Vascor)

Related Therapies and Procedures

1.	Electric Countershock (Cardioversion)
2.	Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
3.	Drug Therapy (Chemotherapy)
4.	Ligation
5.	Defibrillators (Defibrillator)