Abstract | BACKGROUND: METHODS: RESULTS:
Leptin decreased infarct volume and neurologic defects and improved regional cerebral blood flow and microvascular branch blood flow after injury. The malondialdehyde and nitric oxide levels were reduced, and superoxide dismutase level was increased after leptin treatment, which also minimized histologic changes and neuronal apoptosis, led to the upregulation of Bcl-2 and downregulation of caspase-3 expression after injury. CONCLUSIONS: Peripherally administered leptin crossed the blood-brain barrier and was distributed into multiple regions of the brain; in the brain, leptin directly alleviated the injury-evoked damages by reducing oxidative stress and neuronal apoptosis.
|
Authors | Jin-Ying Zhang Jr, Yi-Ling Si, Jie Liao, Guang-Tao Yan, Zi-Hui Deng, Hui Xue, Lu-Huan Wang, Kai Zhang |
Journal | The journal of trauma and acute care surgery
(J Trauma Acute Care Surg)
Vol. 72
Issue 4
Pg. 982-91
(Apr 2012)
ISSN: 2163-0763 [Electronic] United States |
PMID | 22491615
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Leptin
- Nitric Oxide
- Malondialdehyde
- Nitric Oxide Synthase
- Superoxide Dismutase
|
Topics |
- Animals
- Apoptosis
(drug effects)
- Brain Chemistry
(drug effects)
- Brain Ischemia
(drug therapy, metabolism)
- Cerebral Infarction
(drug therapy, metabolism)
- Cerebrovascular Circulation
(drug effects)
- Disease Models, Animal
- Leptin
(pharmacology)
- Male
- Malondialdehyde
(analysis)
- Mice
- Nitric Oxide
(analysis)
- Nitric Oxide Synthase
(metabolism)
- Oxidative Stress
(drug effects)
- Superoxide Dismutase
(metabolism)
|