Intercellular adhesion molecule-1 concentration is genetically correlated with insulin resistance, obesity, and HDL concentration in Mexican Americans.

Abstract

The metabolic syndrome and type 2 diabetes are associated with endothelial activation (and thus with inflammatory processes leading to atherosclerosis), but the mechanisms that underlie these associations are not fully understood. Endothelial intercellular adhesion molecule (ICAM)-1 plays an important role in the recruitment of immune cells during the development of atherosclerotic plaque and is a marker of inflammatory disease. We performed bivariate quantitative genetic analyses to estimate genetic and environmental correlations between circulating ICAM-1 concentration and 17 phenotypes associated with the metabolic syndrome. Our study population comprised 428 adults in 20 extended Mexican-American families from the San Antonio Family Heart Study (SAFHS). Circulating ICAM-1 concentration is heritable (h(2) = 0.56). ICAM-1 concentration showed significant positive genetic correlations (range 0.32-0.52, P < 0.05) with fasting insulin, insulin 2 h after oral glucose challenge, homeostasis model assessment of insulin resistance, BMI, waist circumference, and leptin concentration; negative genetic correlation with HDL3 cholesterol concentration; and negative environmental correlation with adiponectin concentration. Significant genetic correlations were not found between ICAM-1 and fasting or 2-h serum glucose or systolic or diastolic blood pressure. Thus, ICAM-1 expression may share common genetic modulation with traits related to obesity, insulin resistance, and HDL3 cholesterol, but not with hyperglycemia or hypertension per se.

• Authors: Jack W Kent Jr, Anthony G Comuzzie, Michael C Mahaney, Laura Almasy, David L Rainwater, John L VandeBerg, Jean W MacCluer, John Blangero
• Journal: Diabetes (Diabetes) Vol. 53 Issue 10 Pg. 2691-5 (Oct 2004) ISSN: 0012-1797 [Print] United States
• PMID: 15448102 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Blood Glucose
• Lipoproteins, HDL
• Intercellular Adhesion Molecule-1

Topics

• Blood Glucose (metabolism)
• Family
• Female
• Homeostasis
• Humans
• Insulin Resistance (genetics)
• Intercellular Adhesion Molecule-1 (blood, genetics)
• Lipoproteins, HDL (genetics)
• Male
• Metabolic Syndrome (genetics)
• Mexican Americans
• Obesity (genetics)
• Risk Factors
• Texas