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Atherosclerotic Plaque (Atheroma)

Subscribe to New Research on Atherosclerotic Plaque

Lesions formed within the walls of ARTERIES.

Also Known As:

Atheroma; Plaque, Atherosclerotic; Atheromatous Plaques; Atherosclerotic Plaques; Fatty Streak, Arterial; Fibroatheroma; Fibroatheromatous Plaques; Arterial Fatty Streak; Arterial Fatty Streaks; Atheromas; Fatty Streaks, Arterial; Fibroatheromas; Fibroatheromatous Plaque; Plaque, Fibroatheromatous; Plaques, Atherosclerotic; Plaques, Fibroatheromatous; Streak, Arterial Fatty; Streaks, Arterial Fatty

Networked: 7959 relevant articles (178 outcomes, 971 trials/studies)

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Disease Context: Research Results

Signs and Symptoms Pathological Conditions
- Anatomical Pathological Conditions
  - Atherosclerotic Plaque: 7959

Related Diseases

1.	Atherosclerosis
2.	Inflammation
3.	Thrombosis (Thrombus)
4.	Atherosclerotic Plaque (Atheroma)
5.	Pathologic Constriction (Stenosis)

Experts

1.	Libby, Peter: 55 articles (04/2015 - 01/2002)
2.	Pasterkamp, Gerard: 53 articles (04/2015 - 10/2002)
3.	Nissen, Steven E: 45 articles (12/2015 - 06/2002)
4.	Zhang, Yun: 42 articles (10/2015 - 04/2007)
5.	Nicholls, Stephen J: 40 articles (12/2015 - 08/2005)
6.	Fayad, Zahi A: 39 articles (07/2015 - 06/2004)
7.	De Meyer, Guido R Y: 34 articles (09/2015 - 04/2002)
8.	Virmani, Renu: 33 articles (08/2015 - 11/2002)
9.	Serruys, Patrick W: 32 articles (12/2015 - 12/2005)
10.	Egido, Jesús: 32 articles (10/2015 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Atherosclerotic Plaque:

1.	CholesterolIBA 12/01/2013 - "The various rHDL preparations have been shown to be effective in the rapid mobilization of excess cholesterol from cells and in regressing atherosclerotic plaques in animal models. " 01/01/2013 - "Relative to cholesterol-treated animals not receiving SCSE, SCSE-treated animals exhibited significantly improved cardiac function and improved peak early diastolic velocity to peak atrial velocity ratio (E'/A'), along with decreased atherosclerotic plaque formation and infarct size. " 09/28/2012 - "Consequently, Tgh(-/-)/Ldlr(-/-) mice presented with a significant reduction (54%, P<0.01) of the high-fat, high-cholesterol dieteninduced atherosclerotic plaques when compared with Tgh(+/+)/Ldlr(-/-) mice in the cross-sectional aortic root analysis. " 05/30/2000 - "It is concluded that black and red rice might be effective in reducing atherosclerotic plaques on the aorta of rabbits fed a cholesterol-enriched diet. " 03/01/2013 - "The cardiovascular protective effects of HDL particles are attributed, in great part, to the ability of HDL particles to promote cellular cholesterol efflux from lipid-laden macrophages within the atherosclerotic plaque. "
2.	Apolipoproteins E (ApoE)IBA 01/01/2015 - "We found that TXL treatment significantly reduced serum lipid levels and atherosclerotic plaque formation of apoE-deficient mice, and improved endothelial cell function as evidenced by increased expression of CD31 and eNOS. " 12/01/2012 - "Mice transplanted with miR-33(-/-)Apoe(-/-) bone marrow showed a significant reduction in lipid content in atherosclerotic plaque compared with mice transplanted with miR-33(+/+)Apoe(-/-) bone marrow, without an elevation of HDL-C. " 06/15/2012 - "A significant reduction in T-lymphocytes and macrophages was noted in the atheromas of the ApoE(-/-)/Kit(W-sh/W-sh) mice. " 05/01/2006 - "A significant reduction of the atherosclerotic plaque in the aortic sinus and arch with the decrease in smooth muscle cell-positive area was observed in MMP-2(-/-):apoE(-/-) mice compared with that of MMP-2(+/+):apoE(-/-) mice. " 08/01/2015 - "The aim of this study was to characterize effects of low carbohydrate, high protein diet (LCHP) on atherosclerotic plaque development in brachiocephalic artery (BCA) in apoE/LDLR-/- mice and to elucidate mechanisms of proatherogenic effects of LCHP diet. "
3.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 10/01/2014 - "HR MRI shows good inter- and intra-observer reproducibility in identifying MCA-M1 atherosclerotic plaque distribution and vessel and lumen measurements, but its reliability for lumen area measurement at the maximum narrowing site needs to be improved." 01/01/1992 - "Intravascular ultrasound provides high resolution cross-sectional images of vessel walls and may help to characterize atherosclerotic plaque morphology subtypes. " 08/01/2010 - "The results from this study demonstrate that vessel wall imaging could quantify atherosclerotic plaque measurements more reliably with an improved blood suppression technique. " 10/01/2013 - "In the last few years, imaging has allowed the study of smaller fat depots that may interact locally with important tissues: epicardial fat with the myocardium, perivascular fat with the vessel wall and the developing atherosclerotic plaque, and renal sinus fat with the renal artery. " 12/01/2012 - "The aim of this study was to compare images of the vessel wall between symptomatic and asymptomatic atherosclerotic plaques of the middle cerebral artery (MCA) using HRMRI. "
4.	atorvastatin (Lipitor)FDA Link 10/01/2012 - "In this pilot study of Western patients with moderate CAD, high-dose atorvastatin resulted in alterations in coronary atheroma composition with corresponding changes in plaque phenotype and modest improvement in coronary microvascular function." 10/01/2015 - "The purpose of this study was to determine the change of IL-37 in atherosclerotic plaque, the effect of atorvastatin on IL-37 and the association between IL-37 and Smad3 in atherosclerotic disease. " 12/02/2014 - "(Effect of Atorvastatin Therapy on Fibrous Cap Thickness in Coronary Atherosclerotic Plaque as Assessed by Optical Coherence Tomography: The EASY-FIT Study; NCT00700037)." 12/02/2014 - "The aim of this study was to assess the effect of lipid-lowering therapy with 20 mg/day of atorvastatin versus 5 mg/day of atorvastatin on fibrous cap thickness in coronary atherosclerotic plaques by using optical coherence tomography (OCT). " 12/02/2014 - "Effect of atorvastatin therapy on fibrous cap thickness in coronary atherosclerotic plaque as assessed by optical coherence tomography: the EASY-FIT study."
5.	LipidsIBA 08/01/2002 - "LRP is involved in the clearance of lipids from the bloodstream and is expressed in the atherosclerotic plaque. " 11/05/2013 - "This study sought to examine the feasibility of in vivo detection of lipids in atherosclerotic plaque (AP) by ultrasound (US) thermal (or temporal) strain imaging (TSI). " 11/05/2013 - "Noninvasive detection of lipids in atherosclerotic plaque using ultrasound thermal strain imaging: in vivo animal study." 05/25/2011 - "In an early clinical study of human atheroma specimens from four patients, we found that ICG colocalized with plaque macrophages and lipids. " 01/01/2011 - "Aortas were collected at the end of the atherogenic diet periods for quantification of atheroma lesions (en face method), histological and immunohistological studies Ldlr-/- and Plin1-/- Ldlr-/- mice had comparable blood pressure and plasma lipids levels. "
6.	CollagenIBA 01/01/2014 - "dhBBR and Di-MeBBR, but not BBR, reduced atherosclerotic plaque size and improved plaque stability indicated by increased α-smooth muscle actin and collagen content, and thicker fibrous caps. " 02/10/2013 - "The aim of this study was to determine whether inhibition of CD40 signaling by lentivirus-mediated RNA interference (RNAi) could inhibit progression of atherosclerotic plaques and increase collagen production. " 02/01/2013 - "The aim of this study was to analyze how an altered collagen structure affects development of atherosclerotic plaques. " 09/01/2012 - "This study describes a novel fluorescence lifetime imaging (FLIM) classification method to determine the ratio of collagen to lipid content in the fibrous cap of atherosclerotic plaques. " 04/03/2007 - "The purpose of this study was to investigate the measurement of collagen and smooth muscle cell (SMC) content in atherosclerotic plaques using polarization-sensitive optical coherence tomography (PSOCT). "
7.	oxidized low density lipoproteinIBA 01/01/2007 - "Local overexpression of PON-1 almost completely eliminated the immunohistochemical signals of the lectin-like oxidized LDL receptor-1 (LOX-1), thereby inhibiting macrophage accumulation, intimal thickening (by 63% compared with control), or atherosclerotic plaque formation in the vascular lumen (by 87.5%). " 10/01/2014 - "This study reports a new camelid single-domain antibody fragment (sdAb) targeting the Lectin-like oxidized low-density lipoprotein receptor (LOX-1), a biomarker for the detection and molecular phenotyping of vulnerable atherosclerotic plaques. " 01/01/2013 - "Three-dimensional modeling of oxidized-LDL accumulation and HDL mass transport in a coronary artery: a proof-of-concept study for predicting the region of atherosclerotic plaque development." 02/01/2010 - "In the present study, we identified a new protein marker, N-Myc downstream-regulated protein 2 (NDRG2), which is significantly up-regulated in oxidized low density lipoprotein (oxLDL) treated macrophages and in human atherosclerotic plaques. " 12/15/2005 - "Several studies have shown that oxLDL is present in atherosclerotic lesions and that several factors present in active atherosclerotic plaques can oxidatively modify LDL. "
8.	LDL CholesterolIBA 07/21/2015 - "In the statin group, 12 months of statin therapy significantly improved low-density lipoprotein cholesterol levels (125 to 70 mg/dl; p < 0.001), PMR (1.38 to 1.11, an 18.9% reduction; p < 0.001), low-attenuation plaque volume, and the percentage of total atheroma volume on computed tomography. " 09/01/1995 - "Several studies have shown that treatment regimens effective in reducing LDL cholesterol levels lead to regression of atherosclerotic plaques as well as retard the progression of the disease process. " 01/01/2014 - "Systematic study of the effects of lowering low-density lipoprotein-cholesterol on regression of coronary atherosclerotic plaques using intravascular ultrasound." 01/10/2003 - "The present study provides definite evidence that recruitment of macrophages is required for LDL cholesterol clearance, which plays a prominent role in regression of an atheroma." 09/26/1996 - "The studies provide increasing evidence that high LDL cholesterol levels not only contribute to atherosclerotic plaque formation but also interfere with normal endothelial control of arterial vasomotor tone. "
9.	Proteins (Proteins, Gene)IBA 03/01/2012 - "Increased abundance of SAA, C3, and other inflammatory proteins in HDL from ACS patients suggests that HDL reflects a shift to an inflammatory profile which, in turn, might alter the protective effects of HDL on the atherosclerotic plaque. " 01/01/2011 - "The identification of platelet-reactive proteins exclusively present in atherosclerotic plaques could provide interesting targets for effective and safe antithrombotic strategies. " 03/01/2007 - "Smooth muscle cells secrete and deposit ECM proteins and are, therefore, considered protective against atherosclerotic plaque destabilization. " 11/29/2005 - "In this study, BLT(1) receptor proteins were detected in human carotid artery atherosclerotic plaques, colocalizing with markers for macrophages, endothelial cells, and vascular smooth muscle cells (SMC). " 11/01/1998 - "These data further suggest that previous studies demonstrating MDA modified protein in atherosclerotic plaque may in fact have MAA modified proteins associated with them."
10.	Lipoproteins (Lipoprotein)IBA 11/15/2014 - "The aim of this study was to test the hypothesis that high-intensity statin therapy causes equivalent degrees of coronary atheroma regression irrespective of baseline lipoprotein and CRP levels. " 02/15/2008 - "Numerous studies have reported the presence of oxidatively modified high-density lipoprotein (OxHDL) within the intima of atheromatous plaques as well as in plasma; however, its role in the pathogenesis of thrombotic disease is not established. " 05/01/2000 - "In the present study, we compared the effects of nibbling and gorging on postprandial lipaemia and lipoproteins, hepatic lipid uptake and atheroma deposition. " 08/26/1998 - "Several studies have been made of the effects of statin treatment on such variables as endothelial function, cellular immunity, lipoprotein oxidation, rheological factors, and the stabilisation of atherosclerotic plaque. " 10/01/1990 - "Such policies are based on studies of the atherosclerotic plaque, experimental animals, genetic disorders, and lipoprotein metabolism, and from different epidemiological studies and clinical trials. "

Therapies and Procedures

1.	Lasers (Laser) 01/01/1986 - "Direct vaporization of obstructing atheroma with fiberoptic delivery of laser energy has been associated with a high incidence of mural perforation, but each of a variety of techniques, including those for improved energy delivery, plaque recognition, alignment of the fiberoptic, and, perhaps, reduction of unnecessary thermal injury, has shown promise for reducing this complication. " 01/01/1987 - "Laser irradiation (LI) has been effective in vaporizing atherosclerotic plaques. " 11/01/1986 - "Research into improving the efficacy of laser in the vaporisation of atheromatous plaques has led to the study of their modes of emission and to attempts at changing the natural absorption properties of the target lesion. " 08/01/2005 - "This study investigates the use of time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) as a potential tool for detection of macrophage foam cells in the intima of atherosclerotic plaques. " 04/01/1992 - "Pulsed laser and thermal ablation of atherosclerotic plaque: morphometrically defined surface thrombogenicity in studies using an annular perfusion chamber."
2.	Angioplasty (Angioplasty, Transluminal) 12/01/1993 - "These observations may be of particular importance regarding angioplasty in young people where foam cells occupy a significantly greater proportion of the atherosclerotic plaque." 03/01/1997 - "4. These results indicate that BAYw has an inhibitory effect on intimal thickening by attenuating intimal SMC proliferation and infiltration of macrophages, suggesting that BAYw could be effective in the prevention of the progression of atherosclerotic plaque-like restenosis after angioplasty." 08/31/1999 - "Fifteen patients (group I) were enrolled in the study and four sets of samples were obtained (taken from the right atrium both before and after angioplasty, from infarct-related coronary artery thrombi and atherosclerotic plaque aspirated with a TEC and from the thoracic aorta aspirated with a TEC). " 02/01/1997 - "We conclude that the QCA system provides easy-to-achieve standardization of the image acquisition process and sufficient reproducibility for repeated measurement of volume of a coronary artery segment, which can serve as the primary endpoint in clinical trials evaluating atherosclerotic plaque progression or restenosis after angioplasty." 01/01/1985 - "The studies showed desquamation of endothelium, deposition of platelets in the area of angioplasty, and splitting of atheromatous plaques frequently down to the internal elastic membrane. "
3.	Stents 12/01/1998 - "Optimal stent deployment is a pivotal factor for achieving the best results, but the bulk of the atherosclerotic plaque opposes stent expansion and may limit the success of the procedure. " 10/01/2003 - "These data suggest that antecedent HSRA atheroma debulking using HSRA results in improved intravascular stent expansion and reduction in residual plaque, facilitating optimal stent deployment." 01/01/2000 - "We assume that the meshwork of the stent, antiplatelets and periprocedural anticoagulation provide no sufficient protection against materials released from the necrotic core of the atherosclerotic plaque. " 11/01/2015 - "This study reveals that the morphology of atherosclerotic plaques needs to be considered a key parameter in designing coronary stents. " 01/01/2013 - "No clinical study has systematically analyzed and compared circumferential neointimal and plaque distribution of stent neointimal proliferation and in native atherosclerotic plaques. "
4.	Balloon Angioplasty 07/01/1996 - "Newer devices that primarily remove atheroma have not improved outcome over that of balloon angioplasty. " 08/01/1993 - "The in vivo studies demonstrated that intravascular ultrasound can define atheroma lesions not evident on contrast angiography and permits detailed evaluation of the results of interventions such as balloon angioplasty. " 01/01/2011 - "The addition of cryoplasty to balloon angioplasty, which involves the application of cold thermal energy to atherosclerotic plaque, might improve outcomes and decrease the need for reintervention. " 01/15/2008 - "Changes in unstable coronary atherosclerotic plaque composition after balloon angioplasty as determined by analysis of intravascular ultrasound radiofrequency." 05/01/2007 - "We propose physical and finite element models, which are generally useable to trace fissuring and/or dissection in atherosclerotic plaques during balloon angioplasty interventions. "
5.	Catheters 09/01/1993 - "It is concluded that catheter-delivered ultrasound is effective and safe for the disintegration of atherosclerotic plaques. " 10/01/2014 - "Development of a photoacoustic, ultrasound and fluorescence imaging catheter for the study of atherosclerotic plaque." 12/01/2015 - "The novel near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) catheters can detect and quantify the presence of lipid core in the atherosclerotic plaque and associate it with other features such as lumen size and plaque architecture. " 10/01/2015 - "Validating a bimodal intravascular ultrasound (IVUS) and near-infrared fluorescence (NIRF) catheter for atherosclerotic plaque detection in rabbits." 03/01/2015 - "Dispersive aortic cannulas reduce aortic wall shear stress affecting atherosclerotic plaque embolization."