Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)

A cell-surface ligand involved in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue.

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Networked: 5871 relevant articles (165 outcomes, 786 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cuzzocrea, Salvatore: 20 articles (10/2011 - 01/2002)
2.	Mazzon, Emanuela: 18 articles (12/2014 - 01/2002)
3.	Sato, Shinichi: 16 articles (03/2015 - 03/2002)
4.	Yamaya, Mutsuo: 15 articles (10/2015 - 01/2002)
5.	Yu, Huang-Ping: 15 articles (05/2015 - 09/2006)
6.	Mimura, Tatsuya: 14 articles (02/2014 - 05/2005)
7.	Noma, Hidetaka: 14 articles (02/2014 - 05/2005)
8.	Chaudry, Irshad H: 13 articles (05/2015 - 08/2006)
9.	Benjamin, Emelia J: 13 articles (02/2015 - 07/2004)
10.	Dong, Cheng: 13 articles (01/2015 - 04/2005)

Related Diseases

1.	Inflammation 10/01/2000 - "The targeting of CD18 and ICAM-1 may prove useful in the treatment of inflammation-associated neovascularization in the cornea and elsewhere." 12/01/2014 - "Our purpose was to study this paradigm using ICAM-1, an endothelial receptor involved in inflammation, to better understand its regulation and potential for drug delivery. " 03/01/2012 - "Moreover, the critical role of ICAM-1 in Treg adhesion provides a potential explanation for the exacerbation of inflammation reported in some studies of ICAM-1-deficient mice." 01/01/2012 - "This study demonstrated that the renal expression of ICAM-1 was increased in SHR with renal damage, and inflammation may be involved in the hypertensive renal damage." 02/17/2011 - "In the present study, we use 2 models of inflammation to show that endothelial Nogo-B regulates leukocyte transmigration and intercellular adhesion molecule-1 (ICAM-1)-dependent signaling. "
2.	Reperfusion Injury 01/01/2007 - "Protective effects of monoclonal antibody to intercellular adhesion molecule-1 in venous ischemia-reperfusion injury: experimental study in rats." 06/25/2002 - "To study the effect of SOD on the expression of CD11b/CD18 and ICAM-1 after skeletal muscle ischemia / reperfusion injury in rats. " 05/01/1998 - "The purpose of this study was to evaluate the blockage of polymorphonuclear neutrophil endothelial adhesion by using a monoclonal antibody to the intercellular adhesion molecule 1 (ICAM-1) ligand to prevent ischemia-reperfusion injury in rat skin flaps. " 05/01/1998 - "Monoclonal antibody to intercellular adhesion molecule 1 protects skin flaps against ischemia-reperfusion injury: an experimental study in rats." 01/01/2015 - "Use of contrast-enhanced ultrasound to monitor rabbit renal ischemia-reperfusion injury and correlations between time-intensity curve parameters and renal ICAM-1 expression."
3.	Ischemia 05/01/1998 - "In the animals subjected to 12 hours of ischemia, those treated with monoclonal antibody to ICAM-1 (group IV) were 57.1 +/- 23.1 percent viable, which was significantly greater than the control animals (group V), in which only 0.3 +/- 1.0 percent of the flap was viable. " 07/01/2002 - "The present study evaluated the ICAM-1 expression in various organs after 40 min of intestinal ischemia and 1, 3, 6, 12 h of reperfusion (I/R) in the rat, using a dual monoclonal antibody technique (n = 36). " 02/01/1998 - "The purpose of our study was to measure ICAM-1 expression in the liver and other organs after hepatic ischemia/reperfusion (I/R). " 12/01/1995 - "The results of this study indicate that early and persistent ICAM-1 expression occurs following CNS ischemia with associated leukocyte infiltration." 01/01/1993 - "The present study sought to further these observations by examining the site of potential ICAM-1 induction as a function of time of reperfusion, degree of ischemia, and viability of myocardial cells. "
4.	Infection 01/01/2004 - "It is concluded that maternal serum level of ICAM-1 is superior to that of CRP as biomarker for diagnosing intraamniotic infection in pregnant women with PROM." 04/15/1993 - "Recently, a recombinant, soluble ICAM-1 (sICAM-1) has been shown to be effective in prevention of the cytopathic effect of rhinovirus infection in vitro. " 10/01/2015 - "Here, we used human ICAM-1 transgenic (hICAM-1 Tg) mice that support productive HRV infection to assess the efficacy of chimeric HRV expressing the HIV-1 membrane proximal external region (MPER) epitope, 4E10. " 01/01/2014 - "The present study estimated the usefulness of knee skin temperature (measured by infrared thermography) and serum soluble intercellular adhesion molecule-1 (sICAM-1) in the diagnosis of post-operative knee peri-prosthetic infection. " 09/01/2004 - "In this study, we identified functions of ICAM-1 on airway epithelial cells in defense against infection with Haemophilus influenzae. "
5.	Neoplasms (Cancer) 05/01/2015 - "The aim of this study was to evaluate the association between ICAM-1 K469E and G241R polymorphisms and the risk of cancer by meta-analysis. " 01/01/2015 - "ICAM-1 was shown to be mechanistically involved in these inhibitors' ability to sensitize tumor cells to immune-mediated attack by functional blocking studies. " 01/01/2014 - "We searched PubMed, Embase to identify studies that evaluated the association between the ICAM-1 +469 A/G polymorphism and cancer risk. " 01/01/2010 - "Consequently, the herein presented study was performed to investigate if this interaction has also an influence on the migratory activity of the tumor cells and whether ICAM-1 signaling plays a role in this process, too. " 09/01/2009 - "In the present study, serial observations of the localization of ICAM-1 in the liver were made by light and electron microscopy in rats with carcinogen-induced cancer. "

Related Drugs and Biologics

1.	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.	P-Selectin
4.	Interleukin-6 (Interleukin 6)
5.	Lymphocyte Function-Associated Antigen-1 (LFA-1)
6.	Monoclonal Antibodies
7.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
8.	E-Selectin
9.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
10.	NF-kappa B (NF-kB)

Related Therapies and Procedures

1.	Homologous Transplantation (Allograft)
2.	Transplants (Transplant)
3.	Resuscitation
4.	Lasers (Laser)
5.	Warm Ischemia