Dentofacial Deformities

An abnormality of the jaws or teeth affecting the contour of the face. Such abnormality could be acquired or congenital.

Also Known As:

Dentofacial Abnormalities; Dentofacial Dyplasia; Abnormalities, Dentofacial; Abnormality, Dentofacial; Deformities, Dentofacial; Deformity, Dentofacial; Dentofacial Abnormality; Dentofacial Deformity; Dentofacial Dyplasias; Dyplasia, Dentofacial; Dyplasias, Dentofacial

Networked: 425 relevant articles (16 outcomes, 73 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Temporomandibular Joint Disorders (Temporomandibular Joint Disorder)
3.	Hyperplasia
4.	Nasal Obstruction
5.	Hypertrophy

Experts

1.	Posnick, Jeffrey C: 13 articles (05/2020 - 11/2007)
2.	Wolford, Larry M: 7 articles (02/2022 - 04/2002)
3.	Scariot, Rafaela: 7 articles (01/2022 - 12/2017)
4.	Küchler, Erika Calvano: 5 articles (01/2022 - 08/2019)
5.	Choi, Jong Woo: 5 articles (01/2021 - 04/2017)
6.	Jeong, Woo Shik: 5 articles (01/2021 - 04/2017)
7.	Kinard, Brian E: 5 articles (05/2020 - 02/2019)
8.	Choi, Elbert: 5 articles (01/2018 - 03/2016)
9.	Kawashiri, Shuichi: 4 articles (06/2022 - 12/2019)
10.	Ooi, Kazuhiro: 4 articles (06/2022 - 12/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Dentofacial Deformities:

1.	diformyl dapsone (DFD)IBA 05/01/2020 - "The purpose of this study was to document changes in social perceptions and facial esthetics, and document occlusion outcomes in a series of short face (SF) dentofacial deformity (DFD) subjects. " 03/01/2016 - "An index study group consisting of a consecutive series of patients with symptomatic chronic obstructive nasal breathing (CONB) and a bimaxillary developmental dentofacial deformity (DFD) also involving the chin were identified. " 07/01/2022 - "Due to the lack of a specific quality of life (QoL) survey on dentofacial deformities (DFD) for Turkish speakers, the present research aimed to perform a translation of the English version of the Orthognathic Quality of Life Questionnaire (OQLQ) into Turkish (the OQLQ-TR) and provide cultural adaptation to the Turkish population. " 06/01/2022 - "Articulation problems are seen in 80-90% of dentofacial deformity (DFD) subjects compared with 5% of the general population, impacting communication and quality of life, but the causal link is unclear. " 10/01/2017 - "A retrospective study was performed, involving subjects with a bimaxillary developmental dentofacial deformity (DFD) and symptomatic chronic obstructive nasal breathing. "
2.	beta-sitosterol oleateIBA 12/01/2022 - "A total of 37 dentofacial deformity patients included in the study who had undergone OGS were divided into three groups: Group I, Le Fort I maxillary advancement; Group II, bilateral sagittal split osteotomy (BSSO) mandibular advancement ± Le Fort I; and Group III, BSSO mandibular setback ± Le Fort I. Patients were evaluated clinically using Diagnostic Criteria for TMD and by radiography preoperatively and 6 months postoperatively. " 11/01/2023 - "Patients who underwent Le Fort I osteotomy with or without BSSO for dentofacial deformity treatment were studied. " 01/01/2020 - "Bilateral sagittal split osteotomy (BSSO) is a common surgical procedure to correct dentofacial deformities that involve the mandible. " 01/01/2019 - "Orthognathic surgery treatment (OGS) after orthodontic treatment of dentofacial deformities is a widely performed procedure, often accompanied by a bilateral sagittal split osteotomy (BSSO). " 01/01/2018 - "Bilateral sagittal split osteotomy (BSSO) is a widely-performed procedure in orthognathic surgery for the correction of dentofacial deformity. "
3.	Estrogen Receptor alphaIBA 01/01/2022 - "This study aimed to evaluate the associations between oral health-related quality of life (OHRQoL) and patient-associated factors and polymorphisms in the estrogen receptor 1 (ESR1) and 2 (ESR2) genes in patients with dentofacial deformities (DFD). "
4.	Amoxicillin-Potassium Clavulanate Combination (Co-amoxiclav)FDA Link 11/01/2008 - "The present study was designed to evaluate the prophylactic efficacy after the correction of dentofacial deformities between short- and long-term penicillin and amoxicillin-clavulanic acid. "
5.	Transforming Growth Factors (Transforming Growth Factor)IBA 01/01/2020 - "The aim of the study was to evaluate the association between genetic polymorphisms in human epidermal growth factor (EGF) (rs4444903) and transforming growth factor β1 - (TGF-β1) (rs1800470) with facial measurements in patients with dentofacial deformities. "
6.	Prostaglandins FIBA 12/01/2019 - "This study determined the prevalence and characteristics of pneumatized articular eminence (PAE) and pneumatized glenoid fossa (PGF) using cone beam computed tomography (CBCT) scans of patients with and without dentofacial deformities. "
7.	Penicillins (Penicillin)FDA Link 11/01/2008 - "The present study was designed to evaluate the prophylactic efficacy after the correction of dentofacial deformities between short- and long-term penicillin and amoxicillin-clavulanic acid. "
8.	Epidermal Growth Factor (EGF)IBA 01/01/2020 - "Genetic polymorphisms in EGF and TGF-β1 are associated with facial measurements in a Brazilian population of patients with dentofacial deformities." 01/01/2020 - "The aim of the study was to evaluate the association between genetic polymorphisms in human epidermal growth factor (EGF) (rs4444903) and transforming growth factor β1 - (TGF-β1) (rs1800470) with facial measurements in patients with dentofacial deformities. "
9.	TitaniumIBA 10/01/2004 - "Patients with dentofacial deformities were randomly assigned into the titanium and resorbable fixation groups. " 07/01/2022 - "The application of CAD/CAM cutting and drilling guides as well as pre-bent titanium plates could achieve more accurate and favorable outcomes, improving the clinical planning and surgical execution for patients with condylar osteochondroma and secondary dentofacial deformities." 07/01/2022 - "And 8 patients with condylar osteochondroma and secondary dentofacial deformities were treated by the CAD/CAM cutting and drilling surgical guides as well as pre-bent titanium miniplates. " 07/01/2022 - "To investigate current Computer-Aided Design and Computer-Aided Manufacturing (CAD/CAM) technologies applied in the treatment of dentofacial deformities secondary to condylar osteochondroma and introduce a modified method with additional pre-bent titanium miniplates to improve the accuracy of operation. " 07/01/2022 - "Surgical Guides and Prebent Titanium Improve the Planning for the Treatment of Dentofacial Deformities Secondary to Condylar Osteochondroma."
10.	Biomarkers (Surrogate Marker)IBA 01/01/2021 - "The data brings novel evidence about the psychobiological features of patients with dentofacial deformities, showing salivary variations of inflammatory biomarkers in these individuals." 01/01/2021 - "Psychological symptoms and salivary inflammatory biomarkers in patients with dentofacial deformities: a case-control study." 01/01/2023 - "Assessment of temporomandibular disorders and their relationship with life quality and salivary biomarkers in patients with dentofacial deformities: A clinical observational study."

Therapies and Procedures

1.	Orthognathic Surgery 02/01/2023 - "Orthognathic surgery has long been successfully utilized to correct dentofacial deformities to help facilitate improved oral function and facial esthetics. " 01/01/2023 - "When both OHIP-14 and OQLQ scores were examined after orthognathic surgery, the OHRQOL of patients with Class III dentofacial deformity improved significantly." 04/01/2022 - "A significant improvement was observed in oral HRQoL and in the physical component of general health in patients with dentofacial deformities Class II and III after orthognathic surgery. " 01/01/2010 - "Although orthognathic surgery should not be advocated solely for treating TMD, patients having orthognathic treatment for correction of their dentofacial deformities and who are also suffering from TMD appear more likely to see improvement in their signs and symptoms than deterioration." 11/01/2009 - "Although orthognathic surgery should not be advocated solely for treating TMD, patients having orthognathic treatment for correction of their dentofacial deformities and who are also suffering from TMD appear more likely to see improvement in their signs and symptoms than deterioration."
2.	Osteotomy 01/01/2023 - "This study described the mean angulations and linear distances between anatomic structures of the lateral nasal wall in patients with class II and class III dentofacial deformities for the purpose of a safe osteotomy. " 10/01/2013 - "The study included 1234 patients from a single private practice; these patients had dentofacial deformities and underwent Lefort I osteotomy procedures. " 11/01/2011 - "The present study has demonstrated that Hunsuck/Epker–type mandibular split osteotomy together with osteosynthesis with placement of 2 bicortical positioning screws without the adjunctive use of a postoperative maxilla-mandibular fixation in the treatment of mandibular dentofacial deformities results in a low rate of major complications with a high rate of success" 11/01/2011 - "The aim of this study was to prospectively evaluate the accuracy and reliability of the use of the Hunsuck/Epker–type mandibular split osteotomy together with osteosynthesis with placement of 2 bicortical positioning screws without the adjunctive use of a postoperative maxilla-mandibular fixation in the treatment of mandibular dentofacial deformities. " 09/01/2009 - "The aim of the present study was to report the experience of 40 patients who had undergone intraoral verticosagittal ramus osteotomy (IVSRO) to treat dentofacial deformities. "
3.	Joint Prosthesis 04/01/2009 - "End-stage TMJ patients can be treated in one operation with TMJ custom-made total joint prostheses and maxillo-mandibular counter-clockwise rotation, for correction of dentofacial deformity and improvement in pain and TMJ dysfunction; Group 1 patients had better results than Group 2 patients." 01/01/2008 - "In conclusion, end-stage TMJ patients can achieve significant improvement in their pain, dysfunction, dentofacial deformity, and airway problems in one operation with TMJ reconstruction and mandibular advancement using TMJ custom-made total joint prostheses and simultaneous maxillary osteotomies for maxillomandibular counter-clockwise rotation." 09/01/2009 - "Surgical correction of rheumatoid-associated TMJ disease and the resulting dentofacial deformity can successfully be performed in a single operation using custom-made TMJ total joint prostheses to reconstruct the TMJs and advance the mandible, with maxillary orthognathic surgery and genioplasty performed at the same operation when indicated. "
4.	Maxillary Osteotomy 06/01/2014 - "To study the possible morphologic changes in the nose after subnasal modified Le Fort I maxillary osteotomy to correct class III dentofacial deformities in patients with considered normal nasal morphology. " 12/01/2011 - "A prospective, systematic non-randomized study is presented with a series of 47 patients who underwent a Le Fort I maxillary osteotomy due to dentofacial deformity between January 2008 and December 2008. " 06/01/2005 - "In order to mobilize and reposition the maxilla when treating dentofacial deformities, the Le Fort I maxillary osteotomy is commonly used. " 03/01/1979 - "The purpose of this paper is to describe an infraorbital-maxillary osteotomy for correction of this dentofacial deformity and to give a rationale for its use. " 04/01/1978 - "Total maxillary osteotomy for the correction of dentofacial deformities."
5.	Mandibular Advancement 10/01/2023 - "The effect of mandibular advancement for mandibular deficiency dentofacial deformities on laryngeal grade and intubation difficulty: a preliminary study." 10/01/2023 - "This retrospective case series included patients with a diagnosis of mandibular deficiency (Class II skeletal dentofacial deformity) who underwent mandibular advancement surgery (T1) followed by a subsequent surgery (T2) which required intubation. " 10/01/1997 - "Forty consecutive patients with dentofacial deformities requiring bimaxillary orthognathic surgery with maxillary superior repositioning combined with mandibular advancement or setback were included. " 04/01/2018 - "The selected studies fulfilled the criteria established by the following PICO model: (1) population: individuals with skeletal dentofacial deformities (class II or III facial patterns), without asymmetry; (2) intervention: orthognathic surgery for mandibular setback using an SSRO, with or without a Le Fort I osteotomy, and fixed with bicortical screws or plates and screws; (3) comparison: orthognathic surgery for mandibular advancement using an SSRO, with or without a Le Fort I osteotomy, and fixed with plates and screws or bicortical screws; and (4) outcome: condylar resorption rate and relapse. " 01/01/2008 - "In conclusion, end-stage TMJ patients can achieve significant improvement in their pain, dysfunction, dentofacial deformity, and airway problems in one operation with TMJ reconstruction and mandibular advancement using TMJ custom-made total joint prostheses and simultaneous maxillary osteotomies for maxillomandibular counter-clockwise rotation."