Hyperplasia

An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.

Also Known As:

Networked: 20866 relevant articles (632 outcomes, 1837 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Adenoma (Adenomas)
2.	Neoplasms (Cancer)
3.	Hypertrophy
4.	Pathologic Constriction (Stenosis)
5.	Hyperaldosteronism (Conn Syndrome)

Experts

1.	Mintz, Gary S: 52 articles (01/2016 - 06/2002)
2.	Stratakis, Constantine A: 40 articles (01/2016 - 06/2002)
3.	Fitzgerald, Peter J: 29 articles (12/2012 - 02/2002)
4.	Kibbe, Melina R: 28 articles (12/2015 - 06/2007)
5.	Bourdeau, Isabelle: 26 articles (01/2016 - 06/2002)
6.	Serruys, Patrick W: 25 articles (08/2014 - 08/2002)
7.	Lacroix, André: 24 articles (01/2016 - 01/2002)
8.	National Toxicology Program: 24 articles (02/2013 - 01/2001)
9.	Leon, Martin B: 23 articles (11/2015 - 01/2002)
10.	Hong, Myeong-Ki: 23 articles (08/2014 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hyperplasia:

1.	Sirolimus (Rapamycin)FDA Link 04/01/2011 - "The NEVO SES with focal release of sirolimus from reservoirs achieved significantly greater and more consistent suppression of neointimal hyperplasia than the surface-coated TAXUS Liberté PES. " 06/01/2003 - "Neointimal hyperplasia is refractory to conventional immunosuppression although newer agents, such as rapamycin, have shown considerable promise in controlling it. " 08/01/2010 - "In either case, mice lacking Gab2 or treated with rapamycin showed attenuated myeloid hyperplasia and modestly improved survival, but the effects were not cytotoxic and were reversible. " 06/01/2005 - "To evaluate the efficacy of limited short-term systemic administration of rapamycin to prevent neointimal intimal hyperplasia (NIH) in a double-injury rat model of restenosis. " 05/10/2012 - "A perivascular system releasing sirolimus prevented intimal hyperplasia in a rabbit model in a medium-term study."
2.	AldosteroneIBA 04/01/1998 - "Basic hormonal studies and CT can be used effectively to differentiate aldosterone-producing neoplasia from hyperplasia in most cases." 01/01/1980 - "Adrenal vein catheterization with aldosterone determinations was helpful in establishing the presence of hyperplasia in approximately 70% of these cases. " 01/01/2011 - "This study was performed to further investigate if P-450(c11beta) contributes to the overproduction of aldosterone in APA and nodular hyperplasia tissues. " 01/01/2016 - "Conversely, nodular hyperplasia on final pathology may be a risk factor for ongoing aldosterone hypersecretion. " 01/26/2015 - "[High doses of aldosterone antagonist is a condition of sufficient blood pressure control in bilateral adrenal hyperplasia]."
3.	Insulin (Novolin)FDA Link 01/01/2016 - "Other important events observed after surgery were enhanced first phase insulin secretion in a in site pancreatic perfusion experiment, pancreatic hyperplasia, improved islet structure (revealed by immunohistochemical analysis), striking increase in β-cell mass, slight increase in ratio of β-cell area to total pancreas area, and increased number of small islets closely related to exocrine ducts. " 05/01/1994 - "Left-sided resection successfully cured symptoms in two patients with hyperplasia and prompted the diagnosis of insulin autoimmune syndrome. " 09/01/2010 - "In conclusion, these data demonstrate that NO is ineffective at inhibiting neointimal hyperplasia in an uncontrolled rat model of type 1 diabetes; however, insulin administration restores the efficacy of NO at inhibiting neointimal hyperplasia. " 03/01/2012 - "Preclinical studies have indicated that insulin therapy reduces intimal hyperplasia. " 03/01/2007 - "Our present study focuses on the mitochondrial transmembrane protein, hyperplasia suppressor gene/mitofusin2 (HSG/Mfn2), which regulates both mitochondrial fusion (as demonstrated by perinuclear mitochondria clustering) and insulin-dependent myogenesis in vitro. "
4.	Glucose (Dextrose)FDA LinkGeneric 07/01/2011 - "Fluid flow stress promoted hyperplasia and epithelial-mesenchymal transition (EMT) of mesothelial cells independent of glucose concentration. " 10/01/2010 - "High-fat feeding stimulates endocrine, glucose-dependent insulinotropic polypeptide (GIP)-expressing cell hyperplasia in the duodenum of Wistar rats." 10/01/2009 - "Fad24 causes hyperplasia in adipose tissue and improves glucose metabolism." 11/01/2008 - "Ileal adaptation for glucose transport occurs through cellular proliferation (hyperplasia) and not through cellular upregulation of glucose transporters." 01/01/2002 - "Glucose suppresses peritoneal inflammatory reactions and mesothelial hyperplasia caused by intraperitoneal saline infusion."
5.	Dexamethasone (Maxidex)FDA LinkGeneric 08/01/2008 - "Histopathological analysis revealed a marked decrease in epidermal hyperplasia and neutrophil infiltration in animals pretreated with CA or AHAL, in a manner similar to dexamethasone. " 05/01/1994 - "The aim of this study was to determine whether sustained, local administration of the synthetic glucocorticoid dexamethasone reduces the severity of intimal hyperplasia induced by arterial stenting in a porcine model of restenosis. " 06/24/2003 - "Here we report that apoptosis could be induced in TGase2-/- mice; however, the clearance of apoptotic cells was defective during the involution of thymus elicited by dexamethasone, anti-CD3 antibody, or gamma-irradiation, and in the liver after induced hyperplasia. " 03/01/2008 - "In the present study, we evaluated the effects of multiple dexamethasone treatments to assess the relationship between the aggravation of symptoms and mast cell hyperplasia. " 07/01/1999 - "Experimental studies in vivo have demonstrated that dexamethasone inhibits neointimal hyperplasia following arterial injury. "
6.	Adrenocorticotropic Hormone (ACTH)FDA Link 05/28/1983 - "CT of the adrenal glands rapidly and accurately detected the adrenal mass lesions in 2 cases and was effective in documenting bilateral hyperplasia due to ectopic ACTH-dependent disease. " 01/01/2013 - "We evaluated the technical feasibility and efficacy of laparoscopic enucleation of adrenal macronodules in a patient with ACTH-independent macronodular adrenal hyperplasia (AIMAH). " 05/01/2014 - "Four groups of nuclei were used for the current study: spongiocytes and compact cells obtained from adrenocorticotropic hormone (ACTH)-independent macronodular hyperplasia, which were hypothesized to be high risk for nuclear asymmetry, and primary pigmented nodular adrenocortical disease and micronodular adrenocortical hyperplasia samples were used as internal controls. " 11/01/2012 - "The aim of the study was to study the PDE11A gene in a large cohort of patients with ACTH-independent macronodular adrenal hyperplasia (AIMAH) and in control subjects. " 08/01/1994 - "Adrenocorticotropic hormone-independent bilateral adrenocortical macronodular hyperplasia: a case report and immunohistochemical studies."
7.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 04/01/2008 - "In general, the large model exhibits better and more uniform hemodynamic phenomena near the vessel wall and may be effective in preventing the initiation and development of postoperative intimal hyperplasia and restenosis." 07/01/1993 - "Local sustained release from a biodegradable polymeric gel coated on an injured vessel was also effective in the prevention of myointimal hyperplasia. " 06/15/1996 - "We hypothesized that the enforced mechanical remodeling produced by the selection of an oversized Wallstent might result in improved accommodation of subsequent reactive intimal hyperplasia and prevention of chronic recoil of the vessel. " 03/01/2013 - "Sulodexide may alleviate venous intimal hyperplasia by regulating the angiopoietin/Tie system, which may play a significant role in assisting remodeled veins to cope with their new biomechanical environment, but whether the angiopoietin/Tie system is beneficial or not requires further study." 09/01/2005 - "The different in literature proposed conceivable causes of intimal hyperplasia development like surgical interventions, compliance mismatch, wall shear stress (WSS) and shear rate, vessel wall thrill and blood pressure are discussed on the basis of in vivo, in vitro and in numero studies."
8.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 02/20/2004 - "These findings suggest that PDT may be beneficial in reducing intimal hyperplasia for up to three or six months in swine." 01/01/1995 - "These results showed that intravascular PDT was effective in reducing intimal hyperplasia following arterial injury. " 07/01/2004 - "In this study, five patients with oral verrucous hyperplasia (OVH) were treated with a new protocol of ALA-PDT composed of multiple 3-min irradiations with a light emitting diode (LED) red light at 635+/-5 nm separated with several 3-min rests for a total of 1000 s (fluence rate, 100 mW/cm(2); light exposure dose, 100 J/cm(2)) after topical application of 20% ALA for 1.5 or 2 h. " 05/01/1999 - "This study demonstrated that PDT with HPD inhibits smooth muscle cell growth and decreases the intimal hyperplasia response in rabbits." 01/01/1998 - "The aim of this study was to quantify serum and arterial tissue uptake after site-specific photosensitizer delivery and, following PDT, determine its effectiveness at inhibiting intimal hyperplasia. "
9.	DNA (Deoxyribonucleic Acid)IBA 11/01/1995 - "In DNA analysis the relative number of scattered cells in the DNA synthesis phase was significantly greater in nodular than in diffuse hyperplasia. " 01/01/2015 - "Administration of Physalis peruviana L with NNK led to a mild pulmonary hyperplasia and weak expression of Ki-67 and p53 with an improvement in the lung DNA content. " 12/01/2006 - "The purpose of this study was to investigate the presence of HPV DNA in children with benign tonsillar and/or adenoid hyperplasia. " 01/01/2001 - "The aim of the study was to determine whether microcrystals such as these could enhance macrophage survival and induce DNA synthesis, thus indicating that they may contribute to the tissue hyperplasia. " 11/01/1992 - "It was extremely important to measure nuclear DNA content in patients with atypical hyperplasia of the breast in order to study the precancerous lesion and to supervise clinically the tendency of cancerous."
10.	Paclitaxel (Taxol)FDA LinkGeneric 09/01/2007 - "At gross and histological evaluation, considerable pseudointimal hyperplasia had formed in the control group and statistically significant differences were found upon microscopic evaluation in the maximum pseudointimal hyperplasia thickness between the control (2.41 mm, range 1.7-3.16 mm) and animals receiving paclitaxel (0.63 mm, range 0.42-0.98 mm, p<0.05) Local delivery of paclitaxel at the time of TIPS creation may have been effective in reducing pseudointimal/intimal hyperplasia in swine TIPS models." 11/20/2007 - "It is safe and effective to locally use low dose of paclitaxel carried by FG in the prevention of vascular anastomotic site intimal hyperplasia. " 05/01/2007 - "This study evaluated the effect of a bioabsorbable mesh containing paclitaxel on neointimal hyperplasia in a sheep model of dialysis access failure. " 01/01/2007 - "The aim of this study was to assess the effects of paclitaxel and radiation, both singly and in combination on the proliferation of cell types present within the lesion of venous neointimal hyperplasia (vascular smooth muscle cells, fibroblasts and endothelial cells within the neointimal microvessels). " 07/19/2005 - "The aim of this study was to evaluate the effect of variable dose and release kinetics of paclitaxel on neointimal hyperplasia. "

Therapies and Procedures

1.	Stents 11/01/2008 - "They have been very effective in reducing the extent of neointimal hyperplasia and therefore in preventing or minimizing the occurrence of in-stent restenosis. " 05/01/2015 - "In conclusion, 125I seed‑pre‑loaded esophageal stents inhibited benign hyperplasia in the upper edge of the stent to a certain extent, which relieved benign restenosis following implantation with a good safety profile." 03/01/2012 - "From OCT findings at the segment with minimal lumen cross-sectional area (CSA), neointimal hyperplasia (NIH) CSA (5.4 ± 1.7 mm² vs 4.2 ± 2.1 mm²; P=.024) and percent NIH CSA (NIH CSA x 100/stent CSA) were significantly greater in lesions with microvessels (79 ± 12% vs 67 ± 16%; P=.001). " 06/15/2009 - "Moreover, intravascular ultrasound showed a significant reduction of in-stent neointimal hyperplasia formation related to DES use compared with BMS use (Delta neointimal hyperplasia volume 5.4 mm(3) [95% CI 2.7 to 28.1] vs 35.9 mm(3) [95% CI 22.0 to 43.6], p = 0.035). " 02/01/2008 - "Angiographic significant reduction of in-stent restenosis after moderate heating (50 degrees C) was related to in-stent neointimal hyperplasia trend to be lower after moderate local heating when compared with controls. "
2.	Transplants (Transplant) 04/01/2013 - "Although bypass surgery is highly efficacious in the short term, long-term outcomes are limited by relatively high failure rates as a result of intimal hyperplasia, which is a common feature of vein graft disease. " 07/01/2013 - "As constrictive external mesh support of vein grafts led to the complete suppression of intimal hyperplasia (IH) in infrainguinal grafts, we investigated whether mesh constriction is equally effective in the coronary position. " 03/01/2012 - "This was associated with a significant reduction of intimal hyperplasia (average thickness 1.03 ± 0.09 mm in controls vs. 0.69 ± 0.04 mm in coated grafts; P=0.009) and significantly less adhesion of thrombotic material in the middle part of the graft (P=0.029). " 07/01/1990 - "Histologic examination using computer morphometry showed significant reduction of intimal hyperplasia at the proximal, middle, and distal graft segments (p less than 0.05). " 01/01/2009 - "This ability of MRI to more completely identify the geometry of hyperplasia and to quantify the tissue volume in vivo could provide benefits over histologic analysis in assessing the pathology of AV graft failure and the efficacy of antihyperplasia interventions."
3.	Adrenalectomy 04/01/2015 - "PA may be also caused by unilateral hyperplasia, which may be cured by unilateral adrenalectomy. " 09/01/2002 - "All the patients underwent unilateral adrenalectomy, among whom 7 were cured and 1 suffered recurrence 1 month after operation because of medullar hyperplasia in the contralateral adrenal gland. " 02/01/1999 - "Variants of adrenal hyperplasia that share these characteristics can also be cured by unilateral adrenalectomy." 05/01/1990 - "We present 4 patients with clinical, biochemical, imaging, and morphological findings of sporadic unilateral adrenomedullary hyperplasia cured by unilateral adrenalectomy. " 12/01/2008 - "He had coelioscopic left adrenalectomy without complications, microscopic studies showed an hyperplasia of the adrenal medulla. "
4.	Angioplasty (Angioplasty, Transluminal) 02/19/1999 - "These results suggest that MCP-1 promotes neointimal hyperplasia in early neointimal lesion formation and that neutralization of MCP-1 before, and immediately after, arterial injury may be effective in preventing restenosis after angioplasty. " 03/01/1998 - "Gene therapy may be effective in preventing the proliferative component of the intimal hyperplasia: therapeutic genes can be delivered locally to the arterial wall cells at the dilated site during or immediately after angioplasty, using viral (e.g., adenoviruses) or nonviral vectors. " 06/01/2000 - "We wished to (a) assess the efficacy of purified M-T7 protein in inhibiting intimal hyperplasia after angioplasty injury and (b) exploit unique species-specific functions of M-T7 in order to judge the relative importance of each cytokine class on plaque growth. " 09/01/2009 - "Aberrant coronary vascular smooth muscle cell (CSMC) proliferation is a pivotal event underlying intimal hyperplasia, a phenomenon impairing the long-term efficacy of bypass surgery and angioplasty procedures. " 11/01/1998 - "These results suggest that the benefits of c7E3 treatment in coronary angioplasty were not from inhibition of intimal hyperplasia or improved artery wall remodeling. "
5.	Thymectomy 01/01/1990 - "A direct relationship was discovered between the efficacy of thymectomy and intensity of hyperplasia of the glandular lobules of the thymus. " 12/01/2015 - "Value of Prophylactic Cervical Thymectomy in Parathyroid Hyperplasia." 09/15/2015 - "Thymectomy revealed mild thymic nodular hyperplasia. " 07/01/2013 - "She underwent thymectomy, and histological examination revealed follicular hyperplasia. " 12/01/2012 - "Here, we give an overview of the rationale of thymectomy and the standardized macroscopic and histopathological work-up of thymectomy specimens as fixed in MGTX standard operating procedures, including the grading of thymic lymphofollicular hyperplasia and the morphometric strategy to assess thymic involution."