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Nasal Obstruction

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Any hindrance to the passage of air into and out of the nose. The obstruction may be unilateral or bilateral, and may involve any part of the NASAL CAVITY.

Also Known As:

Bilateral Nasal Obstruction; Nasal Airway Obstruction; Nasal Blockage; Unilateral Nasal Obstruction; Airway Obstruction, Nasal; Blockage, Nasal; Blockages, Nasal; Nasal Blockages; Nasal Obstruction, Bilateral; Nasal Obstruction, Unilateral; Obstruction, Bilateral Nasal; Obstruction, Nasal; Obstruction, Nasal Airway; Obstructions, Nasal

Networked: 866 relevant articles (148 outcomes, 83 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Sneezing
2.	Rhinitis
3.	Pruritus (Itching)
4.	Hypertrophy
5.	Snoring

Experts

1.	Nabe, Takeshi: 15 articles (11/2015 - 03/2002)
2.	Mizutani, Nobuaki: 14 articles (11/2015 - 03/2002)
3.	Kohno, Shigekatsu: 14 articles (03/2012 - 03/2002)
4.	Mizutani, N: 7 articles (01/2009 - 04/2001)
5.	Nabe, T: 7 articles (01/2009 - 04/2001)
6.	Kohno, S: 7 articles (01/2009 - 04/2001)
7.	Takenaka, Hiroshi: 7 articles (12/2008 - 08/2003)
8.	Rhee, John S: 6 articles (11/2014 - 07/2008)
9.	Fujii, Masanori: 6 articles (08/2011 - 09/2006)
10.	Jang, Yong Ju: 5 articles (09/2015 - 07/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Nasal Obstruction:

1.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/2008 - "All trials except one showed significant efficacy of intranasal corticosteroids in improving nasal obstruction symptoms and in reducing adenoid size. " 02/01/2015 - "At week 2 and week 6 visits, the nasal obstruction score in the combination therapy groups were significantly improved than that in nasal corticosteroids monotherapy groups (all P < 0.01). " 07/30/2001 - "Regular use of nasal topical corticosteroids are effective in reducing nasal blockage and obstruction. " 07/30/2001 - "The aims of this study were to clarify whether children having active symptoms of AR have increased PAP and to investigate the curative effect of reducing nasal obstruction by topical corticosteroids. " 07/30/2001 - "Our results showed that children with AR may have significantly higher PAP than healthy subjects and decreased to normal levels after relieving nasal blockage by nasal corticosteroids. "
2.	mometasone furoate (mometasone)FDA LinkGeneric 07/01/2010 - "However, mometasone furoate NS therapy significantly improved morning (P = .04) and evening (P = .01) TNSSs, morning (P = .049) and evening (P = .03) nasal obstruction/blockage/congestion, daily peak nasal inspiratory flow (P = .03), flow limitation index (P = .02), Epworth Sleepiness Scale score (P = .048), RQLQ-S score (P = .03), and 2 of 5 WPAI-AS domains. " 06/01/2012 - "This study aims to evaluate the effects of topical mometasone treatment on symptoms and size of adenoid tissue in children with complaints of nasal obstruction and to compare this approach to continuous nasal saline douching plus environmental control alone. " 12/01/2011 - "Powered-assisted partial turbinectomy versus mometasone furoate nasal spray for relief of nasal blockage in chronic or idiopathic rhinosinusitis." 01/01/2008 - "The third randomized, parallel-group trial showed that 77.7% of patients treated with mometasone (100 micrograms/day) for 40 days demonstrated an improvement in nasal obstruction symptoms and a decrease in adenoid size, such that adenoidectomy could be avoided, whereas no significant improvement was observed in the placebo group. " 03/01/2010 - "After ineffective revision sinus surgery and prolonged mometasone furoate application, 19 consecutive mild and moderate NP patients suffering from nasal obstruction (NO) and olfactory dysfunction (OD) were prospectively entered into the study to undergo DLPE under topical anesthesia. "
3.	Budesonide (Pulmicort)FDA LinkGeneric 11/01/2007 - "Both AR and OR can assess the efficacy of budesonide nasal spray treatment for nasal obstruction in patients with PAR. " 08/01/1992 - "Nasal obstruction was the predominant symptom and was subjectively and objectively improved by both doses of budesonide (P less than 0.001). " 11/01/2007 - "We studied the reliability of OR for assessing declining nasal obstruction after budesonide nasal spray treatment. " 12/01/1994 - "The budesonide-treated group also had lower scores for nasal blockage and two eye symptoms (runny and sore eyes), but the differences noted were not significant. " 12/01/1990 - "Switching placebo-treated patients to budesonide treatment resulted in a reduction of nasal blockage (p less than 0.001) and an increase in nasal IFR (p less than 0.001). "
4.	Histamine Antagonists (Antihistamines)IBA 03/01/1977 - "These subjective reports usually noted that nasal blockage or congestion was refractory to antihistamines or minimally relieved by them. " 01/01/1997 - "Antihistamines and nasal blockage." 03/01/1977 - "Before the development of whole body plethysmography, only subjective assessments of antihistamines' effects on nasal blockage or congestion were available. " 02/01/2005 - "Oral antihistamines cause statistically significant improvement in the symptom of nasal obstruction in patients with persistent allergic rhinitis." 02/01/2005 - "Oral antihistamines for the symptom of nasal obstruction in persistent allergic rhinitis--a systematic review of randomized controlled trials."
5.	desloratadine (Aerius)FDA LinkGeneric 04/01/2007 - "Analysis of objective data on nasal blockage demonstrated a significant improvement in nasal airflow with desloratadine, when compared with placebo (SMD 0.32; 95% CI 0.10 to 0.55; P = 0.005). " 06/01/2002 - "In subjects with allergen-induced SAR symptoms, desloratadine significantly reduced the severity of nasal obstruction and accompanying complaints of nasal congestion and other SAR symptoms compared with the effects of placebo." 01/01/2002 - "Positive results were obtained in three single-dose studies; desloratadine 5 mg resulted in a greater improvement from baseline than did placebo in the total symptom score and the nasal obstruction symptom score (P </= 0.02). " 04/01/2003 - "Desloratadine has demonstrated efficacy in treating SAR symptoms, including nasal obstruction. " 06/01/2002 - "Nasal obstruction, as measured by nasal airflow, was less severe with desloratadine than with placebo (P <.02). "
6.	Histamine (Histamine Dihydrochloride)FDA Link 06/01/2007 - "The purpose of this study was to characterize the late phase nasal obstruction that is induced by a nasal histamine challenge in sensitized guinea pigs. " 03/01/2005 - "1. The aim of this study was to investigate the mechanisms by which histamine causes nasal blockage. " 07/01/2014 - "The subjects were scored regarding nasal response encompassing histamine dose and time after histamine administration that caused nasal obstruction (NPT20 score) to assess the treatments' effects. " 06/01/2007 - "A nasal histamine challenge to unsensitized animals induced nasal obstruction at 30 minutes after the challenge while a challenge to sensitized animals induced nasal obstruction not only at 30 minutes but also at 4-6 hours. " 03/01/2005 - "In the presence of both antagonists, there was residual histamine-induced nasal blockage. "
7.	SteroidsIBA 01/01/2004 - "Nasal airflow and nasal obstruction were not significantly altered by steroids during the first 2 h of the study. " 05/01/2013 - "Nasal Obstruction Symptom Evaluation survey preoperatively and postoperatively, prospective outpatient questionnaire to determine use of nasal steroids and presence of nasal allergic symptoms preoperatively and postoperatively. " 12/01/2012 - "Reversible nasal airway obstruction: does change in nasal peak inspiratory flow following decongestion predict response to topical steroids in chronic rhinosinusitis patients?" 01/01/2008 - "Intranasal steroids may be used to reduce nasal airway obstruction. " 01/01/2007 - "This trial showed a significant improvement in quality of life and nasal symptom scores (comprising nasal obstruction and loss of smell scores) and a significant reduction in polyp size after two weeks of treatment with oral steroids compared to no steroid treatment. "
8.	Beclomethasone (Beclometasone)FDA Link 01/01/2008 - "In contrast, one randomised, parallel-group trial did not find significant improvement in nasal obstruction symptoms and adenoid size after eight weeks of treatment with beclomethasone (200 micrograms/day). " 01/01/2008 - "The first eight-week cross-over study showed that treatment with beclomethasone (336 micrograms/day) yielded a greater improvement in mean symptom scores than placebo (-18.5 vs. -8.5, P < 0.05) and a larger reduction in mean adenoid/choana ratio than placebo (right, -14% vs. +0.4%, p=0.002; left, -15% vs. -2.0%, p=0.0006) between week 0 and week 4. The second four-week cross-over study demonstrated that the nasal obstruction index decreased by at least 50% from baseline in 38% of patients treated with beclomethasone (400 micrograms/day) between week 0 and week 2, whereas none of the patients treated with placebo had such improvement (p<0.01). " 03/01/1977 - "A double-blind cross-over study of the effect of insufflation of beclomethasone dipropionate 400 microgram per day for four weeks showed favourable results, as verified statistically, concerning nasal blockage at the end of the treatment period. " 07/01/2007 - " interview after the endoscopy revealed that the patient, a 69-year-old female was diagnosed as chronic perennial allergic rhinitis a few years ago, and had been inhaling rhinenchysis Beclometasone dipropionate (BDP) before sleep every day for the past two years because using this collunarium seemed to mitigate the nasal obstruction and mucus during sleep. " 05/01/1986 - "Sneezing and rhinorrhoea were the same on both drugs, but nasal blockage tended to be less severe on beclomethasone dipropionate. "
9.	fluticasone (Cutivate)FDA LinkGeneric 01/01/2009 - "Fluticasone propionate compared with placebo provided significantly greater relief from nasal obstruction; computed tomographic scans showed significant reductions in the mucosal area of the lower turbinates. " 10/01/1994 - "Clinician- and patient-rated symptom scores indicated greater improvement in nasal symptoms, including nasal obstruction on awakening, among patients receiving intranasal fluticasone propionate. " 09/01/1991 - "Improvement in clinician-rated and patient-rated nasal symptom scores, including morning nasal obstruction, was evident within three days of fluticasone propionate therapy and continued throughout the treatment period. " 12/01/2003 - "To investigate the effect of fluticasone propionate (FP) on the symptom of nasal obstruction and to assess the correlation between the subjective visual analogue score (VAS) and the objective acoustic rhinometry (AR) measurements. " 11/01/1998 - "On the contrary, fluticasone, which acted effectively on nasal obstruction, resulted inefficacious on the other symptoms. "
10.	azelastine (Optivar)FDA LinkGeneric 03/01/2001 - "Intent-to-treat analysis revealed better results in the azelastine group for all assessed symptoms; the significance level was reached for nasal obstruction on day 15 (p = 0.042). " 11/01/1996 - "Intranasal azelastine is useful for the therapeutic management of PAR, mainly in those for whom nasal blockage is not important." 10/01/2013 - "Nevertheless, phototherapy reduced nasal obstruction better than azelastine (p=0.038). " 02/01/2015 - "Azelastine nasal spray and intranasal corticosteroid in combination may provide a substantial therapeutic benefit for patients with persistent non-allergic rhinitis, especially nasal obstruction. " 02/14/1997 - "In conclusion, azelastine has been shown to be effective in the treatment of perennial rhinitis in children aged 5-12 years and to be superior to placebo in the relief of all symptoms assessed, namely sneezing, nasal blockage, nasal itch and rhinorrhea."

Therapies and Procedures

1.	Aftercare (After-Treatment) 11/01/2008 - "After treatment, the symptom of nasal obstruction was significantly improved in the two groups (P < 0.01), with no significant difference between the two groups (P > 0.05). " 12/01/2005 - "Concerning the nasal obstruction and related symptoms, significant improvement was observed at 1 month after treatment in all patients (P < 0.05) and continued up to 3 months after surgery (P < 0.0001). " 05/01/2004 - "Thirteen (93%) of the 14 patients with concomitant external and internal valve dysfunction had improvement in nasal obstruction after treatment. " 12/01/1998 - "Eight weeks after treatment, nasal breathing improved in 21 of 22 patients, with a 58.5% reduction in severity and a 56.5% decrease in the frequency of nasal obstruction. " 09/01/2014 - "Mean VAS scores for nasal obstruction were 6.5±1.2 before treatment and 3.8±1.0 two months after treatment, and the difference between two results was statistically significant (p=0.001). "
2.	Rhinoplasty 08/01/2015 - "In addition, regardless of initial demand and type of surgery, rhinoplasty provides improvement in nasal obstruction, and a positive impact on QoL in most of the patients undergoing rhinoplasty." 05/01/2013 - "Vertical dome division is a versatile technique for nasal tip refinement that resulted in significant improvement in quality-of-life outcomes related to rhinoplasty and nasal obstruction, as well as satisfaction with nasal appearance in a short-term follow-up period. " 07/01/2015 - "Preoperative and 6- and approximately 12-month postoperative scores on the Nasal Obstruction Symptom Evaluation (NOSE) scale (range, 0-20; decreased scores indicate improved functional results) and the Rhinoplasty Outcomes Evaluation (ROE) questionnaire (range, 0-24; increased scores indicate improved aesthetic results). " 07/01/2008 - "There is substantial level 4 evidence to support the efficacy of modern-day rhinoplasty techniques for treatment of nasal obstruction due to nasal valve collapse. " 07/01/2008 - "To systematically review the existing literature supporting the efficacy of modern-day rhinoplasty techniques for treatment of nasal obstruction due to nasal valve compromise. "
3.	Adenoidectomy 01/01/1990 - "In 12 of these cases there was a marked decrease in nasal resistance following decongestion, evidencing the prevalence of functional factors in determining nasal obstruction and contra-indicating adenoidectomy. " 03/01/2003 - "In this study, we followed 227 children <10 years of age who underwent inferior turbinectomy (27 children also underwent a revision of an earlier adenoidectomy), of whom 179 children had significant relief of nasal obstruction at the 1-year follow-up. " 04/01/2014 - "Eighty children between the ages of three and sixteen that had adenoidectomy in our clinic between 2006 and 2010 were compared against eighty age-matched controls who had not had nasal obstruction in their lifetime and were proven to have open nasal airways on physical examination. " 01/01/2013 - "He had recurrent adenoidectomy operation due to nasal obstruction. " 01/01/2013 - "Intranasal steroid provides an efficient nonsurgical alternative to adenoidectomy for theimprovement of adenoid nasal obstruction. "
4.	Lasers (Laser) 12/01/2014 - "After three months, a significant reduction of nasal obstruction was observed for laser treatment and radiofrequency therapy with no significant difference between them. " 11/01/2011 - "There was a significant reduction of nasal obstruction on day 21 postoperatively compared to the preoperative condition on both sides regardless of the laser system used. " 06/01/2005 - "Laser-assisted outpatient septoplasty (LAOS) has a specific clinical application in chronic nasal obstruction due to moderate anterior septal deviation. " 06/01/2004 - "Laser rhinoscopy was used to treat a nasal obstruction in a captive California sea lion (Zalophus californianus). " 06/01/2004 - "Use of laser rhinoscopy to treat a nasal obstruction in a captive California sea lion (Zalophus californianus)."
5.	Osteotomy 10/01/2013 - "The results of this study showed that PIT performed simultaneously with Le Fort I osteotomy is a safe method of managing nasal airway obstruction related to hypertrophied turbinates with minimal complications. " 10/01/2013 - "Hypertrophied turbinates causing significant nasal airway obstruction were present in 603 (49%) of the 1234 patients undergoing Le Fort I osteotomy. " 11/01/1992 - "Management of common problems of nasal airway obstruction in cleft and noncleft patients by the subnasal approach through the maxillary Le Fort I osteotomy are discussed. " 07/01/2014 - "Rhinoplasty with or without osteotomy is an effective treatment for alleviating nasal obstruction symptoms. " 02/01/1998 - "Revision osteotomy with outfracture should be included in the surgeon's armamentarium for the treatment of post-rhinoplasty nasal obstruction."