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Amoxicillin-Potassium Clavulanate Combination (Co-amoxiclav)

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A fixed-ratio combination of amoxicillin trihydrate (see AMOXICILLIN), an aminopenicillin, and potassium clavulanate (see CLAVULANIC ACID), a beta-lactamase inhibitor, used to treat a broad-spectrum of bacterial infections, especially resistant strains.

Also Known As:

Co-amoxiclav; Augmentin; Synulox; Amoxicillin Clavulanic Acid; Amox-clav; Amoxi-Clavulanate; Amoxycillin-Clavulanic Acid; BRL-25000; Clavulanate Potentiated Amoxycillin; Clavulin; Coamoxiclav; Spektramox; Amox clav; Amoxi Clavulanate; Amoxicillin Potassium Clavulanate Combination; Amoxycillin Clavulanic Acid; Amoxycillin, Clavulanate Potentiated; BRL 25000; BRL25000; Clavulanate-Amoxicillin Combination, Potassium; Co amoxiclav; Combination, Potassium Clavulanate-Amoxicillin; Potassium Clavulanate Amoxicillin Combination; Potentiated Amoxycillin, Clavulanate; Amoxicillin-Clavulanic Acid; Potassium Clavulanate-Amoxicillin Combination

Networked: 833 relevant articles (129 outcomes, 161 trials/studies)

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Drug Context: Research Results

Experts

1.	Kenyon, S: 5 articles (10/2008 - 01/2001)
2.	Taylor, D J: 5 articles (10/2008 - 03/2001)
3.	Perry, Caroline M: 5 articles (01/2004 - 01/2002)
4.	Jacobs, Michael R: 4 articles (03/2007 - 10/2002)
5.	Wynne, Brian: 4 articles (08/2006 - 10/2002)
6.	Soriano, Francisco: 4 articles (08/2006 - 11/2003)
7.	Ponte, Carmen: 4 articles (08/2006 - 11/2003)
8.	Twynholm, Monique: 3 articles (01/2015 - 11/2003)
9.	van der Palen, Job: 3 articles (01/2015 - 04/2011)
10.	Hendrix, Ron: 3 articles (01/2015 - 04/2011)

Related Diseases

1.	Infection 06/01/1986 - "BRL25000 proved to be very effective in the treatment of PPNG infection and cured all of 121 patients treated. " 02/16/1985 - "It was concluded that clavulanate-potentiated amoxycillin was an effective treatment of skin infections both under experimental and clinical conditions." 02/01/1985 - "From these results it is concluded that BRL 25000 will be a clinically effective drug in the treatment of mild and moderate infections in the pediatric field." 04/01/1989 - "Augmentin provides safe and effective therapy for infections commonly seen in the pediatric population." 03/01/1986 - "Therefore, BRL 25000 is considered useful for the treatment of genital infections."
2.	Respiratory Tract Infections (Respiratory Tract Infection) 03/01/1993 - "Amoxycillin/clavulanic acid possesses a high clinical and microbiological efficacy for lower respiratory tract infections." 12/01/1985 - "Amoxycillin/clavulanic acid combination was a safe and effective antimicrobial agent for the treatment of respiratory tract infections." 09/01/2000 - "[Pharmacodynamic basis for the use of amoxicillin-clavulanic acid in respiratory infections due to Streptococcus pneumoniae: In vitro studies in an experimental model]." 05/01/1988 - "This study investigated the effects of clavulanate-potentiated amoxycillin in the management of moderate to severe respiratory tract infections. " 05/01/2015 - "Amoxicillin/clavulanic acid (OR = 4.08, 95% CI 1.57-10.56), and respiratory tract infections (RTI) (OR = 6.17, 95% CI 2.55-14.94) were associated with low compliance with guidelines. "
3.	Otitis Media 12/07/1991 - "To determine the efficacy of coamoxiclav in children aged 6 months to 12 years with recurrent acute otitis media. " 12/07/1991 - "Co-amoxiclav in recurrent acute otitis media: placebo controlled study." 01/01/2003 - "Amoxicillin/clavulanic acid: a review of its use in the management of paediatric patients with acute otitis media." 12/01/2002 - "In the intention to treat analysis the frequency of acute otitis media was 16.2% (16/99) in the placebo group and 9.6% (10/104) in the amoxicillin/clavulanic acid group (P = 0.288). " 12/07/1991 - "Co-amoxiclav has no significant benefit over placebo in treating children over 2 years with acute otitis media."
4.	Pneumonia (Pneumonitis) 01/01/2007 - "We investigated the efficacy of 2 formulations of Augmentin on experimental pneumonia due to Haemophilus influenzae (HI) in rabbits. " 01/01/2007 - "Efficacy of humanlike Augmentin SR (2000/125 mg) twice daily treatment on Haemophilus influenzae experimental pneumonia in rabbits." 01/01/2013 - "Finally, we employ the data taken from a trial comparing once-daily gatifloxican with three-times-daily co-amoxiclav in the treatment of community-acquired pneumonia to illustrate the use of these test procedures and sample size calculation formula. " 11/01/2003 - "This randomized, double-blind, double-dummy, multicentre study compared the efficacy and safety of oral co-amoxiclav 2000/125 mg twice daily versus co-amoxiclav 875/125 mg three times daily, for 7 or 10 days, in the treatment of community-acquired pneumonia (CAP). " 02/01/2011 - "The efficacy and safety of amoxicillin-clavulanic acid 1000/125mg twice daily extended release (XR) tablet for the treatment of bacterial community-acquired pneumonia in adults."
5.	Urinary Tract Infections (Urinary Tract Infection) 11/01/1985 - "Amoxicillin-clavulanic acid is effective and safe therapy for acute urinary tract infections caused by susceptible bacteria." 09/01/1983 - "Efficacy of BRL 25000 against Serratia marcescens, Enterobacter cloacae, and Citrobacter freundii in urinary tract infections." 03/01/1990 - "[Clinical study of Augmentin in urinary tract infections in children]." 01/01/2008 - "difficile diarrhoea after co-amoxiclav therapy for a urinary tract infection. " 02/01/2002 - "Exposure to co-amoxiclav as a risk factor for co-amoxiclav-resistant Escherichia coli urinary tract infection."

Related Drugs and Biologics

1.	Amoxicillin (Wymox)
2.	Clavulanic Acid (Potassium Clavulanate)
3.	beta-Lactamases (beta-Lactamase)
4.	Ciprofloxacin (Cipro)
5.	Anti-Bacterial Agents (Antibiotics)
6.	Erythromycin (Erycette)
7.	Azithromycin (Zithromax)
8.	Clarithromycin (Biaxin)
9.	Ofloxacin (Levofloxacin)
10.	Cefuroxime (Zinacef)

Related Therapies and Procedures

1.	Middle Ear Ventilation (Tympanostomy)
2.	Cholecystectomy
3.	Aftercare (After-Treatment)
4.	Intravenous Injections
5.	Injections