B7 Antigens

A family of cell-surface proteins found on ANTIGEN-PRESENTING CELLS. B7 antigens are ligands for specific cell surface receptor subtypes found on T-CELLS. They play an immunomodulatory role by stimulating or inhibiting the T-CELL activation process.

Also Known As:

Networked: 157 relevant articles (4 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Schlom, Jeffrey: 7 articles (08/2019 - 10/2002)
2.	Hodge, James W: 4 articles (09/2015 - 10/2002)
3.	Hodge, J W: 4 articles (05/2003 - 08/2000)
4.	Schlom, J: 4 articles (05/2003 - 08/2000)
5.	Donahue, Renee N: 2 articles (08/2019 - 11/2017)
6.	Gulley, James L: 2 articles (08/2019 - 11/2017)
7.	Heery, Christopher R: 2 articles (08/2019 - 11/2017)
8.	Madan, Ravi A: 2 articles (08/2019 - 11/2017)
9.	Palena, Claudia: 2 articles (08/2019 - 11/2017)
10.	Dirmeier, Ulrike: 2 articles (11/2017 - 09/2015)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2008 - "Recent studies have shown that human and rodent cancer cells, and stromal cells and immune cells in the cancer microenvironment upregulate expression of inhibitory B7 molecules and that these contribute to tumour immune evasion. " 08/01/2016 - "In cancer, deregulation of co-inhibitory B7 molecules is associated with reduced antitumor immunity and cancer immune evasion. " 05/01/2014 - "To test whether fowlpox virus gene therapy is safe and can elicit immune responses in patients with cancer, we conducted a randomized phase I clinical trial of two recombinant fowlpox viruses encoding human B7.1 or a triad of costimulatory molecules (B7.1, ICAM-1, and LFA-3; TRICOM). " 11/01/2012 - "Cancer-associated B7 molecules including B7-H1, B7-DC, B7-H3 and B7-H4 are thought to be involved in the immunoescape of cancer cells and to function as prognostic markers. " 08/01/2011 - "These inhibitory B7 molecules were expressed at high but variable levels by cancer cells. "
2.	Infections 08/01/2023 - "A thorough understanding of the role of B7 molecules during H. pylori infection and GC progression is helpful for the treatment and prevention of GC and the prediction of H. pylori infection outcomes, providing evidence for H. pylori eradication." 07/01/2006 - "The objective of this study was to determine whether adenoviral infection induces B7 molecules and TLR9 on human CEC. " 08/01/1998 - "In the present study we have demonstrated that Salmonella typhimurium infection in mice leads to a progressive loss of CD4+ T helper (Th) cell population, abnormal T-cell death by apoptosis and loss of accessory molecules (B7 and intracellular adhesion molecule-1) on macrophages. " 01/01/2010 - "Expression of B7 costimulatory molecules represents an important compartment of immune response of epithelial cells after microbial infection. " 07/01/2006 - "Ad5 infection induced the expression of B7 molecules and TLR-9 on CEC."
3.	Vaccinia 05/01/2003 - "Murine cells provided with signal 1 and infected with either recombinant vaccinia or avipox vectors containing a TRIad of COstimulatory Molecules (B7-1/ICAM-1/LFA-3, designated TRICOM) induced the activation of T cells to a far greater extent than cells infected with vectors expressing any one or two costimulatory molecules. " 12/12/2001 - "We have recently designed and characterized both recombinant vaccinia and recombinant avipox vectors containing the transgenes for a triad of human T cell costimulatory molecules (B7-1, ICAM-1, LFA-3; designated TRICOM). " 11/15/1999 - "Murine cells provided with signal 1 and infected with either recombinant vaccinia or avipox vectors containing a TRIad of COstimulatory Molecules (B7-1/ICAM-1/LFA-3, designated TRICOM) induced the activation of T cells to a far greater extent than cells infected with any one or two costimulatory molecules. " 07/01/2001 - "The studies reported here demonstrate that one can utilize other APCs, such as bone marrow progenitor cells (BMPCs) and make them markedly more effective as APCs; this was accomplished by their infection with recombinant poxviruses (either the replication-defective avipox or vaccinia), which contain transgenes for a triad of costimulatory molecules (B7-1, ICAM-1 and LFA-3, designated TRICOM). " 09/29/2015 - "An alternative therapeutic strategy is a vaccine comprised of a Modified vaccinia Ankara (MVA), incorporating the Twist transgene and a TRIad of COstimulatory Molecules (B7-1, ICAM-1, LFA-3; TRICOM). "
4.	Multiple Sclerosis 01/01/1984 - "Some immunogenetic HLA markers are significantly correlated with multiple sclerosis, e.g.: the antigens B7, DR2, and the associations B7-DR2, A3-B7-DR2. " 05/03/1999 - "Blocking B7 molecules may be beneficial in the treatment of established CNS inflammatory demyelinating diseases such as multiple sclerosis." 04/01/1999 - "The aberrant expression of B7 costimulatory molecules is involved in the pathogenesis of autoimmune diseases and overexpression of B7-1 was found in inflammatory multiple sclerosis (MS) lesions. " 11/01/1990 - "The data suggest a lack of association between A3 and B7 antigens and Italian multiple sclerosis and a relevance of other DR locus antigens (mainly DR4 and DR5), in addition to DR2, in the susceptibility to the disease."
5.	Neoplasm Metastasis (Metastasis) 08/01/1999 - "This chapter deals with: 1) comparative studies on the use of a dual-gene construct of a recombinant vaccinia (rV) vector containing a tumor-associated antigen (TAA) gene and a co-stimulatory molecule gene vs the use of admixtures of rV-TAA and rV containing the co-stimulatory molecule to induce anti-tumor immunity; 2) the use of an admixture of vaccinia viruses containing a TAA gene and the B7-1 co-stimulatory molecule gene to induce a therapeutic response in a lung metastasis tumor model; 3) the antitumor efficacy of whole-tumor-cell vaccines in which the B7-1 co-stimulatory molecule is expressed in a tumor-cell vaccine via a vaccinia vs a retroviral vector; 4) the use of recombinant poxviruses containing the genes for the co-stimulatory molecules ICAM-1 or LFA-3 to induce antitumor immunity; and 5) the use of poxvirus vectors containing a triad of co-stimulatory molecules (B7-1, ICAM-1 and LFA-3) that synergize to enhance both CD4+ and CD8+ T-cell responses to a new threshold."

Related Drugs and Biologics

1.	Antigens
2.	Vaccines
3.	Proteins (Proteins, Gene)
4.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
5.	Cytokines
6.	Interleukin-12 (IL 12)
7.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
8.	Interleukin-10 (Interleukin 10)
9.	Interleukin-7 (Interleukin 7)
10.	Genetic Markers (Genetic Marker)

Related Therapies and Procedures

1.	Immunotherapy
2.	Therapeutics
3.	Ligation