Cholic Acid

02/01/1980 - "Plasma clearance of oral and intravenous cholic acid in subjects with and without chronic liver disease."
09/01/1977 - "This study raises the possibility that the clinical liver disease seen in patients with a metabolic block in the conversion of THCA into cholic acid may be caused by tauro-THCA."
03/01/1991 - "[Cholic acid levels in the serum of dairy cows with metabolically-caused liver diseases]."
01/01/1985 - "Diagnostic value of fasting and postprandial conjugated serum cholic acid in chronic liver diseases."
01/01/1985 - "In general, an increased serum level of cholic acid indicated more serious liver disease. "

09/01/1975 - "Studies were carried out in a family in which two children with cholestasis due to intrahepatic bile duct anomalies were shown to have increased amounts of the cholic acid precursor, 3alpha, 7alpha, 12alpha-trihydorxy-5beta-cholestan-26-oic acid (THCA). "
02/01/2013 - "However, coadministration of epiallopregnanolone sulfate with cholic acid exacerbated the hypercholanemia and resulted in aberrant gene expression profiles for hepatic bile acid-responsive genes consistent with cholestasis. "
06/01/2007 - "Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis."
07/30/1996 - "Cholic acid was the prevailing bile acid in chronic cholestasis (51%) and was elevated eight-fold as compared to group C (P < 0.005). "
01/01/1981 - "A cholic acid/chenodesoxycholic acid quotient higher than 1.0 is a sign of cholestasis. "

08/01/1973 - "Factors affecting plasma clearance of (14C) cholic acid in patients with cirrhosis."
11/01/1973 - "Patients with mild cirrhosis also had significantly reduced cholic acid synthesis (average 152 mg per day) but they all were well and alive three to 23 months after the study. "
11/01/1973 - "Nine of the 10 patients with advanced cirrhosis and a very low cholic acid synthetic rate (average 68 mg per day) died within one to 13 months from the start of the study. "
10/01/2010 - "KO mice on a cholic acid diet had higher hepatic and serum bile acid levels, bile ductular reaction, increased pericellular fibrosis, and dilated, misshapen bile canaliculi. "
06/01/2010 - "Cirrhosis produced a decrease in basal force, depressed beta-adrenoceptor responsiveness, and altered ECC similar to cholic acid. "

03/01/1979 - "Cholic acid (CA) production rate (171 +/- 28 to 395 +/- 9 mg/hr, p less than 0.05) and pool size (727 +/- 80 to 1209 +/- 132 mg/hr, p less than 0.05) were increased during long term treatment of gallstone subjects, while the proportion of CA in bile and deoxycholic aicd (DCA) in feces increased. "
01/01/1975 - "It is concluded that the CDCA metabolism is similar to that of cholic acid in gallstone patients. "
02/01/1989 - "In addition, the estimated hepatic uptake of unconjugated and conjugated cholic acid was determined in 15 gallstone patients undergoing cholecystectomy. "
07/01/1975 - "The use of cholic acid T tube infusion and of the Burhenne catheter has been investigated in the management of gallstones retained in the common bile duct following biliary surgery in 9 patients. "
04/21/2006 - "The results indicate a critical role for cholic acid for the development of hypercholesterolemia and gallstones in our animal model."

01/01/1990 - "[Bacteriocholia and cholic acid level in the bile in cholelithiasis]."
01/01/1990 - "Infection of the biliferous system in patients with cholelithiasis was shown to be the most frequent when the levels of cholic acid in bile were low. "
08/04/1973 - " the bile of patients without cholelithiasis the molar percent of cholic acid was significantly greater in men while that of chenodeoxycholic acid was significantly greater in women.In"
06/01/1989 - "Cholelithiasis in hamsters: effects of cholic acid and calcium on gallstone formation."
03/01/2004 - "To study whether mucin gene 1 (Muc1) influences susceptibility to cholesterol cholelithiasis, we investigated male Muc1-deficient (Muc1(-/-)) and wild-type mice fed a lithogenic diet containing 1% cholesterol and 0.5% cholic acid for 56 days. "