HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Chenodeoxycholic Acid (Chenix)

Subscribe to New Research on Chenodeoxycholic Acid

A bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.

Also Known As:

Chenix; Chenodiol; Antigen Brand of Chenodeoxycholic Acid; Chenique Acid; Chenofalk; Chenophalk; Estedi Brand of Chenodeoxycholic Acid; Falk Brand of Chenodeoxycholic Acid; Henohol; Quenobilan; Quenocol; Sodium Chenodeoxycholate; Solvay Brand of Chenodeoxycholic Acid; Tramedico Brand of Chenodeoxycholic Acid; Zambon Brand of Chenodeoxycholic Acid; Acid, Chenic; Acid, Chenique; Acid, Chenodeoxycholic; Acid, Gallodesoxycholic; Chenodeoxycholate, Sodium; Chenic Acid; Chenodeoxycholate; Gallodesoxycholic Acid; Cholan-24-oic acid, 3,7-dihydroxy-, (3alpha,5beta,7alpha)-

Networked: 715 relevant articles (36 outcomes, 93 trials/studies)

Relationship Network

Drug Context: Research Results

Polycyclic Compounds: 56
- Steroids: 18537
  - Bile Acids and Salts: 3397
    - Cholic Acids: 8
      - Deoxycholic Acid: 627
        Chenodeoxycholic Acid: 715
        chenodeoxycholate sulfate conjugate: 203
        Glycochenodeoxycholic Acid: 43
        Taurochenodeoxycholic Acid: 40
        HS 1200: 11
        3,7-dihydroxycholane-24-sulfonate: 6
        6-ethylchenodeoxycholic acid: 6
        HS-1199: 6
        23-norchenodeoxycholic acid: 1
        3,7-dihydroxy-25,26-bishomocholane-26-sulfonate: 1
        homochenodeoxycholic acid: 1
        1-hydroxychenodeoxycholic acid
        16-hydroxychenodeoxycholic acid
        23-hydroxychenodeoxycholic acid
        24-norchenodeoxycholic acid
        3,7-dihydroxy-12-oxocholanoic acid
        3,7-dihydroxy-24-norcholane-23-sulfonate
        3,7-dihydroxy-25-homocholane-25-sulfonate
        3,7-dihydroxychol-5-enoic acid
        3-glucosido-chenodeoxycholic acid
        3-oxo-7-hydroxychol-4-enoic acid
        3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate
        avicholic acid
        chenodeoxycholyl-2-(4-N-nitrobenzoxadiazolyl)aminobutyl-glycine
        chenodeoxycholyl-nitrobenzoxadiazolyl-lysine
        chenodeoxycholyllysylrhodamine
        chenodeoxycholyltyrosine
        deoxycholyl-L-lysyl-methylester
        methyl 3,7-dihydroxychol-4-en-24-oate
        methyl 3,7-dihydroxycholanate
        N-(2-aminoethyl)-3,7-dihydroxycholan-24-amide
        N-chenodeoxycholyl-2-fluoro-beta-alanine
        sarcochenodeoxycholic acid
        sodium 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanate
  - Cholanes
    - Cholic Acids: 8
      - Deoxycholic Acid: 627
        Chenodeoxycholic Acid: 715
        chenodeoxycholate sulfate conjugate: 203
        Glycochenodeoxycholic Acid: 43
        Taurochenodeoxycholic Acid: 40
        HS 1200: 11
        3,7-dihydroxycholane-24-sulfonate: 6
        6-ethylchenodeoxycholic acid: 6
        HS-1199: 6
        23-norchenodeoxycholic acid: 1
        3,7-dihydroxy-25,26-bishomocholane-26-sulfonate: 1
        homochenodeoxycholic acid: 1
        1-hydroxychenodeoxycholic acid
        16-hydroxychenodeoxycholic acid
        23-hydroxychenodeoxycholic acid
        24-norchenodeoxycholic acid
        3,7-dihydroxy-12-oxocholanoic acid
        3,7-dihydroxy-24-norcholane-23-sulfonate
        3,7-dihydroxy-25-homocholane-25-sulfonate
        3,7-dihydroxychol-5-enoic acid
        3-glucosido-chenodeoxycholic acid
        3-oxo-7-hydroxychol-4-enoic acid
        3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate
        avicholic acid
        chenodeoxycholyl-2-(4-N-nitrobenzoxadiazolyl)aminobutyl-glycine
        chenodeoxycholyl-nitrobenzoxadiazolyl-lysine
        chenodeoxycholyllysylrhodamine
        chenodeoxycholyltyrosine
        deoxycholyl-L-lysyl-methylester
        methyl 3,7-dihydroxychol-4-en-24-oate
        methyl 3,7-dihydroxycholanate
        N-(2-aminoethyl)-3,7-dihydroxycholan-24-amide
        N-chenodeoxycholyl-2-fluoro-beta-alanine
        sarcochenodeoxycholic acid
        sodium 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanate

Experts

1.	Kim, Nam Deuk: 9 articles (10/2008 - 03/2003)
2.	Suh, Hongsuk: 8 articles (10/2008 - 03/2003)
3.	Yoo, Young Hyun: 8 articles (04/2007 - 03/2003)
4.	Choi, Yung Hyun: 5 articles (10/2008 - 09/2003)
5.	Fiorucci, Stefano: 4 articles (12/2014 - 11/2004)
6.	Staels, Bart: 4 articles (03/2008 - 02/2003)
7.	Federico, A: 3 articles (01/2013 - 09/2001)
8.	Dotti, M T: 3 articles (01/2013 - 09/2001)
9.	Kosykh, Vladimir: 3 articles (11/2004 - 02/2003)
10.	Fruchart, Jean-Charles: 3 articles (11/2004 - 02/2003)

Related Diseases

1.	Gallstones (Gallstone) 03/01/1982 - "Of 125 patients with radiolucent gallstones in functioning gallbladders treated with chenodeoxycholic acid (CDCA) between 1971 and 1977, 47 showed complete gallstone dissolution--an overall efficacy of 38%. " 01/01/1980 - "Chenodeoxycholic acid (CDCA) is an effective treatment for dissolving gallstones but experimental studies have suggested that it might be hepatotoxic. " 03/01/2002 - "Most clinical trials on PBC therapy have used conservative dosages of UDCA similar to those of chenodeoxycholic acid (CDCA) used for dissolution of gallstones. " 09/01/1991 - "Samples were obtained from National Cooperative Gallstone Study patients (n = 17) with abnormal light microscopic liver biopsy results or major aminotransferase elevations and from a matched control group of patients (n = 14) who received similar chenodiol doses but had no evidence of liver injury. " 06/01/1990 - "One hundred and twelve patients with radiolucent gallstones entered the study; 54 received chenodeoxycholic acid (CDCA) and 58 ursodeoxycholic (UDCA) at dosage of 15 mg/kg/daily. "
2.	Body Weight (Weight, Body) 12/01/2013 - "During the first 6 d after weaning, piglets were intragastrically infused once daily with either deionized water (control), chenodeoxycholic acid (CDC; 60 mg/kg body weight), or β-sitoesterol (BSE; 100 mg/kg body weight). " 08/01/1986 - "It was shown that feeding chenodeoxycholic acid (CDCA) for 24 days in dosages of 15, 30, and 60 mg/kg of body weight, all depressed PD equally but significantly (P less than 0.05) in three groups of dogs compared with a control group. " 06/01/1983 - "Chenodeoxycholic acid was given to 97 patients in a dosage of 15 mg/kg of body weight per day for a period of two years. " 11/01/1978 - "Chenodeoxycholic acid became a major bile acid averaging 10.4 +/- 1.6 mg/kg body weight/day. " 01/01/1985 - "Such patients may benefit from a trial of Chenodiol therapy at a dose of 15 mg/kg of body weight and experience both fewer symptoms and reduced need for medically indicated cholecystectomy. "
3.	Cholestasis 05/01/2013 - "Two neonatal cholestasis patients with mutations in the SRD5B1 (AKR1D1) gene: diagnosis and bile acid profiles during chenodeoxycholic acid treatment." 05/01/2005 - "Here, we describe the effect of 6-ethyl chenodeoxycholic acid (6-ECDCA or INT-747), a semisynthetic bile acid derivative and potent FXR ligand, in a model of cholestasis induced by 5-day administration of 17alpha-ethynylestradiol (E(2)17alpha) to rats. " 03/01/1995 - "Cholestatic concentrations of chenodeoxycholate conjugates directly inhibit the activity of microtubule motors, suggesting a possible mechanism for impairment of vesicular transport in cholestasis." 07/01/1993 - "Chenodeoxycholate is toxic to hepatocytes, and accumulation of chenodeoxycholate in the liver during cholestasis may potentiate hepatocellular injury. " 08/01/1992 - "Accordingly, we assessed the respective effects of cholestasis, chenodeoxycholic acid (CDCA), and UDCA, using mixed lymphocyte culture as a model of allogeneic immune response. "
4.	Liver Diseases (Liver Disease) 05/01/2013 - "Primary bile acid treatment using chenodeoxycholic acid was effective for these patients treated in early infancy before the late stage of chronic cholestatic liver dysfunction." 03/01/1990 - "An ultrastructural study of patients with and without overt liver disease and the effect of chenodeoxycholic acid treatment." 03/01/1977 - "A perfusion technique has been used to study the effect of sodium chenodeoxycholate (5 mmol 1-1) on absorption of oxalate (2 mmol 1-1) from the surgically excluded colon in two patients with chronic liver disease. " 09/01/2014 - "Liver disease in infancy caused by oxysterol 7 α-hydroxylase deficiency: successful treatment with chenodeoxycholic acid." 05/01/2002 - "Ursodeoxycholate (the beta- epimer of chenodeoxycholate) is approved for the treatment of chronic cholestatic liver disease. "
5.	Constipation 01/01/1983 - "The aim of this study was to investigate whether the cathartic effect of chenodeoxycholic acid (CDCA) could be helpful in the management of chronic constipation. " 01/01/1983 - "Treatment of constipation with chenodeoxycholic acid." 11/01/2010 - "Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysis." 12/01/1983 - "There was a significant improvement of constipation in the combined chenodeoxycholic acid groups when they were compared with the combined ursodeoxycholic acid groups. " 01/01/1994 - "Today, chenodeoxycholate has other medicinal uses and is used for the management of cerebrotendinous xanthomatosis, hypertriglyceremia, congenital liver diseases, rheumatoid arthritis, and constipation. "

Related Drugs and Biologics

1.	Ursodeoxycholic Acid (Urso)
2.	Cholesterol
3.	Cholic Acid
4.	Bile Acids and Salts (Bile Acids)
5.	Magnesium
6.	Phenobarbital (Luminal)
7.	hyodeoxycholic acid
8.	Taurine
9.	Glycine (Aminoacetic Acid)
10.	Cholestanol (Coprostanol)

Related Therapies and Procedures

1.	Lithotripsy (Extracorporeal Shockwave Lithotripsy)
2.	Oral Administration
3.	Withholding Treatment
4.	Liver Transplantation
5.	Cholecystectomy