Anisakiasis

Infection with roundworms of the genus ANISAKIS. Human infection results from the consumption of fish harboring roundworm larvae. The worms may cause acute NAUSEA; VOMITING; or penetrate into the wall of the DIGESTIVE TRACT where they give rise to EOSINOPHILIC GRANULOMA in the STOMACH; INTESTINES; or the OMENTUM.

Also Known As:

Networked: 130 relevant articles (2 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hypersensitivity (Allergy)
2.	Infection
3.	Trichuriasis
4.	Ascariasis
5.	Abdominal Pain (Pain, Abdominal)

Experts

1.	Daschner, A: 9 articles (02/2014 - 01/2000)
2.	Cuéllar, C: 8 articles (02/2014 - 05/2001)
3.	Daschner, Alvaro: 7 articles (05/2015 - 05/2002)
4.	Rodero, M: 7 articles (02/2014 - 05/2001)
5.	Ubeira, F M: 5 articles (02/2014 - 04/2000)
6.	Cuéllar, Carmen: 4 articles (05/2015 - 05/2002)
7.	Moneo, Ignacio: 4 articles (06/2014 - 07/2002)
8.	Ishizaki, Shoichiro: 4 articles (06/2011 - 05/2007)
9.	Nagashima, Yuji: 4 articles (06/2011 - 05/2007)
10.	Shiomi, Kazuo: 4 articles (06/2011 - 05/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Anisakiasis:

1.	Albendazole (Albenza)FDA Link 12/01/2014 - "The aim of this study was to determine the efficacy of peppermint essential oil (EO) and its main components against the parasite in comparison to albendazole, a drug currently prescribed to treat anisakiasis. " 12/01/2014 - "Peppermint (Mentha piperita) and albendazole against anisakiasis in an animal model." 07/06/2002 - "Treatment of anisakiasis with albendazole." 12/15/2005 - "Albendazole for the treatment of anisakiasis ileus."
2.	Immunoglobulin E (IgE)IBA 05/01/2014 - "Among patients presenting acute gastric anisakiasis-like symptoms, a diagnosis of gastroallergic anisakiasis may be strongly supported by a high Anisakis-specific IgE titer." 05/01/2014 - "Both the results of skin prick tests and elevated Anisakis-specific IgE titers (>17.5 kU/L) were found to be reliable indicators for the diagnosis of gastroallergic anisakiasis. " 05/01/2012 - "Diagnosis in gastro-allergic anisakiasis (GAA) is straightforward, when clinical history is combined with further allergological evaluation of specific IgE by means of skin prick test and serum specific IgE. " 01/01/2011 - "Low immunoglobulin E response in gastroallergic anisakiasis could be associated with impaired expulsion of larvae." 04/01/2003 - "She also had a serologic test for immunoglobulin E specific to anisakiasis and it was highly positive. "
3.	AntibodiesIBA 08/01/2002 - "We review 23 cases of digestive anisakiasis registered between 1989 and 2001, and confirmed by the measurement of specific serum Ig E antibodies. " 02/01/2008 - "Human anisakiasis can be specifically diagnosed by detection of immunoglobulin E (IgE) antibodies against O-deglycosylated nAni s 7 allergen captured by monoclonal antibody (mAb) UA3 (UA3-ELISA), although the nature of this important allergen is unknown. " 11/01/1986 - "[Analysis of antigens defined by anti-anisakis larvae IG-G and IG-E antibodies in sera of patients with acute gastric anisakiasis]." 04/01/2010 - "Our findings suggest that ELISA methods with Ani s 7 and Ani s 1 allergens as targets of IgE antibodies are currently the best option for serodiagnosis of human anisakiasis, combining specificity and sensitivity. " 02/01/2008 - "The sequence MCQCVQKYGTEFCKKRLA from rAni s 7 was identified as the epitope recognized by mAb UA3, and is the target for over 60% of human IgE antibodies that react with O-deglycosylated nAni s 7. In addition to their clear value for serodiagnosis of human anisakiasis, the nature of the novel sequences and epitopes identified in the Ani s 7 allergen are of interest for a better understanding of the mechanisms operating in Anisakis-induced allergy."
4.	AllergensIBA 01/01/2014 - "Anisakiasis is caused by the consumption of raw or undercooked fish or cephalopods parasitized by live L3 larvae of nematode Anisakis spp. Larvae anchor to stomach mucosa releasing excretion/secretion products which contain the main allergens. " 04/01/2010 - "Commercially available serological methods for serodiagnosis of human anisakiasis either are poorly specific or do not include some of the most relevant Anisakis allergens. " 04/01/2010 - "Diagnosing human anisakiasis: recombinant Ani s 1 and Ani s 7 allergens versus the UniCAP 100 fluorescence enzyme immunoassay." 04/01/2008 - "Not only may allergic symptoms arise from infection by the parasites ("gastroallergic anisakiasis"), but true anaphylactic reactions can also occur following exposure to allergens from dead worms by food-borne, airborne, or skin contact routes. " 04/01/2010 - "Our findings suggest that ELISA methods with Ani s 7 and Ani s 1 allergens as targets of IgE antibodies are currently the best option for serodiagnosis of human anisakiasis, combining specificity and sensitivity. "
5.	styrene-methylmethacrylate copolymerIBA 02/01/2015 - "Anisakiasis in humans in South Korea has been considered to be caused exclusively by the larvae of Anisakis simplex sensu stricto and Pseudoterranova decipiens. " 12/01/2014 - "Anisakis morphotype I is the principal etiologic agent of human anisakiasis, with differences in pathogenicity found between the Anisakis simplex s.s. " 06/01/2012 - "Anisakis simplex sensu stricto and Anisakis pegreffii: biological characteristics and pathogenetic potential in human anisakiasis." 12/01/2010 - "We analyse this symptom-complex in the context of Gastro-allergic Anisakiasis (GAA), where the human is an incidental host for the cosmopolitan fish-nematode Anisakis simplex (A. " 10/01/2010 - "Anisakiasis outbreak by Anisakis simplex larvae associated to Peruvian food in Spain."
6.	AntigensIBA 02/01/2014 - "The main objective of the study was to determine the degree of sensitization to Anisakis spp. antigens in healthy coastal population of Dalmatia given the high thermally unprocessed fish intake rate present in this area, suggested as a significant risk factor for anisakiasis. " 08/01/2004 - "This antigen detection assay may have application in the diagnosis of anisakiasis." 08/01/2004 - "Detection of circulating antigens in experimental anisakiasis by two-site enzyme-linked immunosorbent assay." 01/01/2003 - "When the sera from persons diagnosed with anisakiasis by means of endoscopy were analyzed using indirect ELISA and Western blot, the sera was classified into four groups depending on specific antigen recognition patterns. " 01/01/2003 - "Human anisakiasis: Diversity in antibody response profiles to the changing antigens in larval excretions/secretions."
7.	Immunoglobulin G (IgG)IBA 01/01/2003 - "Human anisakiasis was researched for specific IgG with L3 excretory secretory products (ESP). " 07/01/2002 - "Among patients with intestinal anisakiasis, 86% showed specific IgE, but only 29% had specific IgG (P < 0.001, two-tailed Fisher exact test). " 12/01/1991 - "Changes of IgM and IgG antibody levels in experimental rabbit anisakiasis as observed by ELISA and SDS-PAGE/immunoblot." 05/01/2015 - "haemoglobin IgE and IgG4 levels were higher in gastro-allergic anisakiasis than in chronic urticaria patients (P=0.002 and 0.026, respectively). " 12/01/1990 - "In nine cases of gastric anisakiasis, three of them were positive for IgG response, five for IgE, and six for IgA, respectively. "
8.	Immunoglobulins (Immunoglobulin)IBA 01/01/2008 - "Anisakis simplex is a nematode which can parasitize humans, producing anisakiasis and can induce immunoglobulin-(Ig)-E-mediated allergic symptoms. " 05/01/2002 - "Gastro-allergic anisakiasis has been reported as an entity in which an acute parasitism by Anisakis simplex is accompanied by an immunoglobulin (Ig)E-mediated systemic allergic reaction. " 05/01/2003 - "simplex and high total and specific immunoglobulin (IgE) in the first month after the parasitation, could be a useful tool in the diagnosis of gastrointestinal anisakiasis, even if the parasite cannot be isolated." 07/01/2002 - "Forty-nine non-fish-allergic patients with Anisakis simplex hypersensitivity, 21 patients without allergic episodes suffering intestinal anisakiasis with obstruction of the intestinal lumen, and 10 unrelated sera as a control were included in this study to determine specific immunoglobulin (Ig)E and IgG to Anisakis simplex major allergen Ani s 1 by immunoblotting. "
9.	BariumIBA 12/01/1992 - "Eighteen consecutive patients with intestinal anisakiasis were studied with high-resolution ultrasound (US) and barium studies. "
10.	Proteins (Proteins, Gene)IBA 08/01/1986 - "These findings suggest that, in addition to being potent immunogens, larval excretory secretory proteins are produced in sufficient quantity to modulate the host response in anisakiasis." 08/01/1986 - "Serum from a human anisakiasis patient reacted with these proteins in immunoblots, indicating that, during invasion of the gastric mucosa, enough of them are produced in vivo to induce an immune response. " 01/01/2012 - "Although no cases of human anisakiasis have been reported in Morocco to date, part of a randomly selected population in Northern Morocco shows sensitization to A simplex proteins." 05/01/2008 - "Larvae invading the gastrointestinal mucosa excrete/secrete proteins that are implicated in the pathogenesis of anisakiasis and can induce IgE-mediated symptoms. " 07/01/2007 - "Larvae invading the gastrointestinal mucosa excrete/secrete proteins implicated in the pathogenesis of anisakiasis that can induce IgE mediated symptoms. "

Therapies and Procedures

1.	Laparotomy 02/01/2013 - "Enteric anisakiasis is very rare, and its diagnosis is usually made after laparotomy. " 01/01/2003 - "Enteric anisakiasis is very rare, and its diagnosis is usually only made after laparotomy. " 07/01/2003 - "Anisakiasis is a misdiagnosed and underestimated cause of acute abdomen: most patients undergo laparotomy, and virtually no cases are diagnosed before surgery. " 09/08/1979 - "To the list of the well known parasitic diseases which are expressed by acute abdominal syndromes and which need laparotomy, we may now add the anisakiasis. " 03/01/1998 - "Patients who have acute abdomen after recent ingestion of seafood and in whom ascites, small bowel dilatation, and focal edema of Kerckring's folds are seen by sonography should be suspected of having small intestinal anisakiasis and should be treated conservatively without laparotomy."
2.	Surgical Instruments (Clip) 07/01/1989 - "Endoscopic examination with biopsy forceps has facilitated the diagnosis of gastric anisakiasis. " 02/15/1985 - "Because the larvae of Anisakis can always be observed by endoscopy and removed with biopsy forceps, early performance of endoscopy is highly recommended for patients in whom acute gastric anisakiasis is suspected and for those who have eaten raw fish within 12 hours before onset of the gastric symptoms. "
3.	First Aid (Aids, First) 07/01/2011 - "The oral administration of medicine containing wood creosote might be effective as a first aid to ameliorate the symptoms of Anisakiasis."
4.	Colectomy 07/01/2008 - "A total colectomy was performed and the diagnosis of synchronous sigmoid colon cancer and anisakiasis of the ascending colon was confirmed. "
5.	Oral Administration 07/01/2011 - "The oral administration of medicine containing wood creosote might be effective as a first aid to ameliorate the symptoms of Anisakiasis." 07/01/2011 - "Two cases of gastric Anisakiasis for which oral administration of a medicine containing wood creosote (Seirogan) was effective."