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Gastrointestinal Diseases (Functional Gastrointestinal Disorders)

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Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.

Also Known As:

Functional Gastrointestinal Disorders; Gastrointestinal Disorders, Functional; Disease, Gastrointestinal; Diseases, Gastrointestinal; Disorder, Functional Gastrointestinal; Disorders, Functional Gastrointestinal; Functional Gastrointestinal Disorder; Gastrointestinal Disease; Gastrointestinal Disorder, Functional; Infantum, Cholera; Cholera Infantum

Networked: 1735 relevant articles (71 outcomes, 147 trials/studies)

Relationship Network

Disease Context: Research Results

Digestive System Diseases: 46
- Gastrointestinal Diseases: 1735

Related Diseases

1.	Pain (Aches)
2.	Irritable Bowel Syndrome (Syndrome, Irritable Bowel)
3.	Neoplasms (Cancer)
4.	Abdominal Pain (Pain, Abdominal)
5.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease)

Experts

1.	Camilleri, Michael: 10 articles (03/2013 - 01/2005)
2.	McClane, Bruce A: 8 articles (01/2013 - 01/2005)
3.	Ehling-Schulz, Monika: 7 articles (01/2015 - 01/2005)
4.	Suchodolski, Jan S: 6 articles (01/2015 - 10/2006)
5.	Steiner, Jörg M: 6 articles (01/2015 - 10/2006)
6.	Saps, Miguel: 6 articles (08/2014 - 04/2009)
7.	Balescu, Irina: 5 articles (12/2015 - 06/2015)
8.	Dima, Simona: 5 articles (12/2015 - 06/2015)
9.	Popescu, Irinel: 5 articles (12/2015 - 06/2015)
10.	Ruaux, C G: 5 articles (05/2013 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Gastrointestinal Diseases:

1.	Antidepressive Agents (Antidepressants)IBA 02/01/2009 - "Several studies have suggested that antidepressants might be beneficial in the treatment of patients with functional gastrointestinal disorders. " 01/01/2000 - "Treatment of functional gastrointestinal disorders with antidepressants appears to be effective. " 01/01/2000 - "We performed a meta-analysis of published, English-language, randomized clinical trials on the use of antidepressants for the treatment of patients with functional gastrointestinal disorders. " 06/01/2015 - "All patients with complex functional gastrointestinal disorders visiting for consultation were included and treated with antidepressants, psychotherapy, or both, or given advice for treatment in their own region. " 02/01/2014 - "Gastrointestinal symptoms are frequently reported adverse effects of antidepressants, but antidepressants are also a treatment modality in functional gastrointestinal disorders. "
2.	Ganciclovir (Cytovene)FDA LinkGeneric 08/01/1987 - "Ganciclovir may be effective in treating cytomegalovirus gastrointestinal disease in patients with the acquired immunodeficiency syndrome." 04/01/1988 - "Extensive trials with intravenous ganciclovir, a nucleoside analogue with myelosuppressive toxicity, have shown that ganciclovir halts the progression of cytomegalovirus retinitis and gastrointestinal disease. " 04/01/1993 - "Nineteen male homosexuals with AIDS and biopsy-proven CMV gastrointestinal disease who had twice failed standard ganciclovir induction (defined as progression of clinical CMV disease) were studied. " 09/01/1990 - "Favorable clinical responses to ganciclovir have been reported in approximately 80% of immunocompromised patients with CMV retinitis or gastrointestinal disease. " 06/01/1988 - "In both retinitis and gastrointestinal disease patients, ganciclovir decreased recovery of CMV from urine and blood markedly. "
3.	Foscarnet FDA LinkGeneric 06/01/1997 - "Twice-daily foscarnet appeared to be safe and efficacious in the treatment of CMV gastrointestinal disease in this study, resulting in endoscopic or histologic improvement in 9 of the 10 (90%) patients. " 07/01/1995 - "For HCMV gastrointestinal disease, complete or partial response rates of 57-95% have been reported with foscarnet. " 04/01/1993 - "Foscarnet appears to induce remission of CMV gastrointestinal disease in 67% of patients when ganciclovir induction has failed. " 09/01/1995 - "Patients with symptomatic gastrointestinal disease due to cytomegalovirus (CMV) were randomized to receive open-label ganciclovir (22) or foscarnet (26). " 04/01/1993 - "This compassionate-use study examined the efficacy of foscarnet in patients with AIDS and cytomegalovirus (CMV) gastrointestinal disease who had failed ganciclovir induction. "
4.	Amitriptyline (Elavil)FDA LinkGeneric 08/28/2014 - "The study findings suggest that once patients with functional gastrointestinal disorders have been screened for prolonged QTc interval on baseline EKG, they probably do not need a second EKG for reevaluation of cardiac conduction after starting low dose amitriptyline." 09/01/2012 - "The study was a secondary analysis of data obtained from a double-blind, randomized, placebo-controlled trial, evaluating amitriptyline in children with functional gastrointestinal disorders. " 10/01/2009 - "Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders." 08/28/2014 - "Electrocardiograms changes in children with functional gastrointestinal disorders on low dose amitriptyline." 10/01/2009 - "The aim of this study was to evaluate the efficacy of amitriptyline in children with pain-predominant functional gastrointestinal disorders. "
5.	rifaximin (L 105)FDA Link 02/15/2006 - "Additional studies should be performed to further define the role of rifaximin in the treatment of gastrointestinal diseases in adults and children." 10/24/2004 - "According to the clinical studies rifaximin could be an adequate therapeutic approach in all gastrointestinal diseases and interventions when antibacterial therapy is needed." 01/01/2016 - "Introduction: understanding mechanisms of the actions of rifaximin in selected gastrointestinal diseases." 11/21/2015 - "Rifaximin is a non-absorbable antibiotic used in the management of several gastrointestinal diseases. " 08/01/2015 - "Therapeutic Effects and Mechanisms of Action of Rifaximin in Gastrointestinal Diseases."
6.	AntibodiesIBA 01/01/2009 - "To examine content, diagnostic and prognostic role of autologous antibodies in gastrointestinal diseases (GID). " 10/01/2005 - "A high rate of seropositivity for antibodies against Helicobacter pylori has been found in many extra-gastrointestinal diseases. " 06/01/2000 - "* Detection of anti-enteric neuronal antibodies may be a useful diagnostic test for early stages of inflammatory degenerative neuropathy in patients with symptoms of a functional gastrointestinal disorder. " 01/01/1999 - "To measure circulating antibodies to yeast organisms that could be used to characterise the yeast specific immune response in gastrointestinal disease. " 01/01/1999 - "Circulating antibodies to Saccharomyces cerevisiae (bakers'/brewers' yeast) in gastrointestinal disease."
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/01/2009 - "TNF alpha inhibition as treatment modality for certain rheumatologic and gastrointestinal diseases." 08/01/2002 - "Functional relevance of soluble TNF-alpha, transmembrane TNF-alpha and TNF-signal transduction in gastrointestinal diseases with special reference to inflammatory bowel diseases." 08/01/1996 - "As tumour necrosis factor (TNF)-alpha may mediate these features this cytokine was measured in the faeces of HIV-seropositive individuals with diarrhoea to assess its role in the pathogenesis of HIV-related gastrointestinal disease and the association with specific intestinal pathogens. " 01/01/2014 - "Treatment of Crohn's disease with an anti-tumor necrosis factor alpha agent (infliximab) successfully induced remission of both the gastrointestinal disease and the oral lesion. " 10/01/2013 - "The objectives of this study were to (1) evaluate the effects of equine soluble CD14 (sCD14) and monoclonal antibodies (mAb) to equine CD14 on lipopolysaccharide-induced tumor necrosis factor α (TNF-α) secretion from equine peripheral blood mononuclear cells (PBMC); and to (2) determine serum concentrations of sCD14 in a population of horses with gastrointestinal diseases or other illnesses likely to result in endotoxemia. "
8.	EnterotoxinsIBA 11/01/2005 - "An enterotoxin (cpe) plasmid was cured from a Clostridium perfringens non-food-borne gastrointestinal disease (NFBGID) isolate, and the heat resistance levels of wild-type, cpe knockout, and cpe plasmid-cured strains were compared. " 06/01/2011 - "The Agr-like quorum-sensing system regulates sporulation and production of enterotoxin and beta2 toxin by Clostridium perfringens type A non-food-borne human gastrointestinal disease strain F5603." 02/01/2006 - "Complete sequencing and diversity analysis of the enterotoxin-encoding plasmids in Clostridium perfringens type A non-food-borne human gastrointestinal disease isolates." 05/01/2005 - "Association of beta2 toxin production with Clostridium perfringens type A human gastrointestinal disease isolates carrying a plasmid enterotoxin gene." 01/01/1998 - "Evidence that the enterotoxin gene can be episomal in Clostridium perfringens isolates associated with non-food-borne human gastrointestinal diseases."
9.	Lactose FDA LinkGeneric 11/01/2006 - "Although rare, intolerance to lactose should be considered in the differential diagnosis of gastrointestinal diseases that can cause malabsorption of LT(4). " 03/01/1982 - "Of 123 children with chronic gastrointestinal diseases examined on an inpatient basis, 65 (53%) showed lactose hydrolysis disorder. " 03/01/1985 - "Considering 50 children affected by sub-acute gastrointestinal diseases by severe growth disorders, we have compared the "one-hour blood xylose test" with the "xylose and lactose H2 breath test, looking for a relationship with the duodeno-jejunal mucosal damage. " 08/01/1990 - "3. In 143 patients with gastrointestinal disease, excretion of both ingested raffinose and lactose was significantly increased in coeliac disease in relapse or in partial remission and in Crohn's disease, but not in the irritable bowel syndrome, coeliac disease in remission or ulcerative colitis. " 11/01/1990 - "To assess the hydrolytic capability of lactase-containing tablets taken immediately before oral lactose challenge, we studied 18 children previously identified as being lactose intolerant and having no underlying organic gastrointestinal disease. "
10.	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA 09/01/2011 - "Long-term efficacy of low-dose tricyclic antidepressants for children with functional gastrointestinal disorders." 04/01/1996 - "The efficacy of unselected monoamine reuptake inhibitors (tricyclic antidepressants) in the treatment of patients with functional gastrointestinal disorders (FGD) has not been convincingly demonstrated. " 04/01/2009 - "Patients with functional gastrointestinal disorders treated with tricyclic antidepressants sometimes report nongastrointestinal symptoms; it is unclear whether these are drug side effects or reflect a behavioral tendency to report symptoms. " 02/01/1998 - "Tricyclic antidepressants in low doses are widely used in the therapy of patients with functional gastrointestinal disorders, yet the mechanism(s) of action of these drugs in these disorders is not known. "

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 05/01/2014 - "Although more controlled trials are needed, faecal microbiota transplantation therapy shows promise in both adults and children with gastrointestinal diseases such as CDI and IBD." 01/01/2015 - "Is fecal microbiota transplantation (FMT) an effective treatment for patients with functional gastrointestinal disorders (FGID)?" 04/01/2014 - "Intestinal microbiota and the efficacy of fecal microbiota transplantation in gastrointestinal disease." 11/27/2015 - "Fecal microbiota transplantation in gastrointestinal diseases: what practicing physicians should know." 01/01/2015 - "Fecal microbiota transplantation in gastrointestinal disease: 2015 update and the road ahead."
2.	Enteral Nutrition (Feeding, Tube) 12/01/2000 - "We conclude that enteral nutrition is very useful for gastrointestinal disease, but that social problems affect home care with enteral nutrition." 11/01/2014 - "Cost-effectiveness analysis of an enteral nutrition protocol for children with common gastrointestinal diseases in China: good start but still a long way to go." 01/01/2007 - "[Enteral nutrition in the therapy of gastrointestinal diseases (according to materials of the European Association of Parenteral and Enteral Nutrition)]." 05/01/2001 - "[Parenteral and enteral nutrition in children with gastrointestinal diseases]." 12/01/2000 - "[Enteral nutrition for gastrointestinal disease in home care]."
3.	Parenteral Nutrition 05/01/2002 - "Therefore, the hypothesis that parenteral nutrition (PN) is beneficial for horses with severe gastrointestinal disease was investigated in a retrospective study. " 06/01/1991 - "The present study investigated the effects of two modalities of parenteral nutrition (continuous nutrition over the 24-hour period vs. cyclic nutrition, i.e., administered only during the night) on O2 consumption during sleep in children affected by severe gastrointestinal diseases. " 07/01/2015 - "IF was defined as severe congenital or acquired gastrointestinal diseases during infancy with dependence on parenteral nutrition (PN) >60 days. " 01/01/2011 - "Our experience in the treatment of paediatric patients with gastrointestinal diseases confirms that long-term parenteral nutrition has become a safe and appropriate method in the treatment of severe chronic intestinal failure." 05/01/2002 - "Parenteral nutrition for horses with gastrointestinal disease: a retrospective study of 79 cases."
4.	Complementary Therapies (Alternative Medicine) 03/01/2012 - "The aim of this study was to describe the complementary and alternative medicine methods most commonly used to alleviate symptom distress in persons with functional gastrointestinal disorders. " 08/01/2008 - "This study was designed to assess complementary and alternative medicine use in children with different gastrointestinal diseases, including functional disorders, to determine which factors predicted complementary and alternative medicine use and to assess the willingness of parents to participate in future studies on complementary and alternative medicine efficacy and safety. " 01/01/2002 - "Our study indicates the use of alternative medicine occurs across all demographic groups in one-third of patients with chronic liver and gastrointestinal diseases at a major general hospital in Taipei. " 01/01/2002 - "A hospital-based study on the use of alternative medicine in patients with chronic liver and gastrointestinal diseases." 07/01/2015 - "Complementary and Alternative Medicine Use Is Prevalent Among Patients with Gastrointestinal Diseases."
5.	Drug Therapy (Chemotherapy) 03/01/1998 - "The best treatment of CMV gastrointestinal disease has been controversial, with some centers adding intravenous (i.v.) Ig to antiviral chemotherapy. " 07/01/2015 - "In this article, we describe a case of complex functional gastrointestinal disorders associated with posttraumatic autonomic neuropathy that was refractory to pharmacotherapy and was successfully treated with an integrative East-West approach. " 12/14/2014 - "In refractory autoimmune gastrointestinal diseases high-dose chemotherapy followed by HSCT seems feasible and safe and might result in long-term improvement of disease activity. " 03/01/2012 - "However, pharmacogenetics could have a beneficial role in enabling pharmacotherapy for nonmalignant gastrointestinal diseases to be targeted to the individual patient." 09/01/2010 - "Challenges and prospects for pharmacotherapy in functional gastrointestinal disorders."