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[The results of proton radiosurgery for pituitary endosellar adenomas].

Abstract
465 patients with pituitary endosellar adenomas have passed irradiation on the synchrocyclotron PNPI (1000 MeV). Due to the high energy of the proton beam the rotating-convergent shoot-through technique was used. The single dose of 80-100 Gy was given. In patients with prolactin adenomas clinical remission was detected in 80%, and the stabilization of the disease was achieved in 15%. Pregnancies in 21 patients ended in the birth of healthy children, and 4 of them gave the birth twice. Complete clinical remission was observed in 92% of patients with Cushing's disease. Sustained recovery and full normalization of growth hormone level were observed during long-term follow-up in 86% of patients with acromegaly. There was significant reducing of the high hormone level on the fifth year of follow-up in any clinical form of pituitary adenomas while the development of the secondary hypopituitarism was not defected in the most of the patients. Clinical remission in patients with non-secreting adenomas was 95%. Irradiation by the proton beam was not accompanied by serious life-threatening complications. Thus this type of treatment for pituitary endosellar adenomas is highly effective and safe and, sometimes, the only method.
AuthorsA M Granov, R A Shalek, D L Karlin, V M Vinogradov, N N Ialynych, T V Pushkareva, O P Zargarova, S V Gerasimov, Iu A Koshkin
JournalVoprosy onkologii (Vopr Onkol) Vol. 59 Issue 4 Pg. 465-9 ( 2013) ISSN: 0507-3758 [Print] Russia (Federation)
PMID24032220 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Pituitary Hormones
  • Adrenocorticotropic Hormone
  • Prolactin
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
  • Thyrotropin
  • Growth Hormone
  • Hydrocortisone
Topics
  • Adenoma (blood, surgery)
  • Adolescent
  • Adrenocorticotropic Hormone (blood)
  • Adult
  • Female
  • Follicle Stimulating Hormone (blood)
  • Follow-Up Studies
  • Growth Hormone (blood)
  • Humans
  • Hydrocortisone (blood)
  • Luteinizing Hormone (blood)
  • Male
  • Pituitary Hormones (blood, radiation effects)
  • Pituitary Neoplasms (blood, surgery)
  • Prolactin (blood)
  • Proton Therapy
  • Radiosurgery (adverse effects, methods)
  • Radiotherapy, Computer-Assisted
  • Thyrotropin (blood)
  • Time Factors
  • Treatment Outcome

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