465 patients with pituitary endosellar
adenomas have passed irradiation on the
synchrocyclotron PNPI (1000 MeV). Due to the high energy of the
proton beam the rotating-convergent shoot-through technique was used. The single dose of 80-100 Gy was given. In patients with
prolactin adenomas clinical remission was detected in 80%, and the stabilization of the disease was achieved in 15%. Pregnancies in 21 patients ended in the birth of healthy children, and 4 of them gave the birth twice. Complete clinical remission was observed in 92% of patients with
Cushing's disease. Sustained recovery and full normalization of
growth hormone level were observed during long-term follow-up in 86% of patients with
acromegaly. There was significant reducing of the high
hormone level on the fifth year of follow-up in any clinical form of
pituitary adenomas while the development of the secondary
hypopituitarism was not defected in the most of the patients. Clinical remission in patients with non-secreting
adenomas was 95%. Irradiation by the
proton beam was not accompanied by serious life-threatening complications. Thus this type of treatment for pituitary endosellar
adenomas is highly effective and safe and, sometimes, the only method.