Neurotoxins

Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept.

Also Known As:

Networked: 1305 relevant articles (30 outcomes, 100 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Johnson, Eric A: 20 articles (01/2015 - 09/2003)
2.	Montecucco, Cesare: 18 articles (12/2015 - 05/2003)
3.	Binz, Thomas: 16 articles (12/2015 - 02/2004)
4.	Rossetto, Ornella: 14 articles (12/2015 - 05/2003)
5.	Tepp, William H: 14 articles (01/2015 - 09/2003)
6.	Barr, John R: 13 articles (07/2015 - 01/2009)
7.	Kalb, Suzanne R: 12 articles (07/2015 - 01/2009)
8.	Barbieri, Joseph T: 12 articles (02/2014 - 04/2006)
9.	Rummel, Andreas: 11 articles (12/2015 - 02/2004)
10.	Smith, Leonard A: 11 articles (01/2015 - 10/2007)

Related Diseases

1.	Seizures (Seizure) 02/24/1995 - "In this study we have investigated whether excitotoxin-induced seizure activity affects the release and tissue content of CCK. " 01/01/1995 - "We are applying multi-nuclear high-field (500 MHz) MR spectroscopy of metabolising whole tissue preparations of the mammalian brain to studies on individual components of convulsions, which include prolonged depolarization, metabolic deprivation, and the effects of excitotoxins. " 01/01/1986 - "Here I have reviewed evidence from electron microscopic studies showing that each of several sustained limbic seizure syndromes is associated with a type of acute brain damage which is ultrastructurally indistinguishable from the brain damage induced by Glu and other excitotoxins. " 11/01/2013 - "That is why neurotoxins may elicit an effect for the restraint of the seizures. " 09/01/2013 - "Long-lasting attenuation of amygdala-kindled seizures after convection-enhanced delivery of botulinum neurotoxins a and B into the amygdala in rats."
2.	Alzheimer Disease (Alzheimer's Disease) 09/04/1989 - "A recent approach to identifying the factors that predispose neurons to an early death in Parkinson's or Alzheimer's disease has been to study how the effect of specific neurotoxins are altered by increasing maturity. " 07/21/2014 - "Oligomers of the Aβ42 peptide are significant neurotoxins linked to Alzheimer's disease (AD). " 03/16/2012 - "Soluble Aβ oligomers formed during early aggregation process are believed to be neurotoxins and causative agents in Alzheimer disease. " 05/04/2007 - "Thus, tau reduction can block Abeta- and excitotoxin-induced neuronal dysfunction and may represent an effective strategy for treating Alzheimer's disease and related conditions." 08/01/2005 - "Processes of novelty learning and keeping the results in Alzheimer's disease in two groups of rhesus-monkeys (three monkeys in each group), were studied: following neurotoxins administrati- on (I group) and saline administration (II group). "
3.	Paralysis (Palsy) 06/30/1986 - "The differences in efficacy of 3,4-DAP against the four serotypes of Bo Tx together with previously reported variations in specific toxicity and duration of paralysis may reflect differences in the pharmacological activity of these neurotoxins." 06/12/2015 - "botulinum neurotoxins (BoNT) via contaminated feed and is characterized by flaccid paralysis. " 05/01/2015 - "Botulinum neurotoxins (BoNTs) are the most poisonous substances known to mankind, which act on the peripheral nervous system leading to flaccid paralysis. " 01/01/2014 - "Botulinum neurotoxins (BoNTs) cause flaccid paralysis by inhibiting neurotransmission at cholinergic nerve terminals. " 09/03/2013 - "Botulinum neurotoxins (BoNTs) can cause paralysis at exceptionally low concentrations and include seven serotypes (BoNT/A-G). "
4.	Glaucoma 08/01/2014 - "Glaucoma considered as an imbalance between production and clearance of neurotoxins." 08/01/2014 - "Glaucoma considered as an imbalance between production and clearance of neurotoxins." 01/01/2015 - "This would suggest a new hypothesis for glaucoma, which, just like Alzheimer's disease, might be considered then as an imbalance between production and clearance of neurotoxins, including amyloid-β. "
5.	Parkinson Disease (Parkinson's Disease) 01/01/2016 - "In conclusion, this study demonstrates key differences in the pattern of motor dysfunction induced by Parkinsonian neurotoxins which should be taken into consideration when selecting the most appropriate model for Parkinson's disease preclinical studies. " 01/01/2010 - "It is a critical study of scientific methodology best suited to the etiology of Parkinson's disease, essential basis for its prevention, with an overview of the main factors incriminated between environmental highlighting the effect of neurotoxins, hoping to complete the health aspects this important disease in an essay in which he attends the literature." 07/01/2003 - "Numerous studies have shown that endogenous and/or environmental neurotoxins and oxidative stress may participate in the pathogenesis of Parkinson's disease (PD), but the detailed mechanisms are still unclear. " 03/01/1996 - "Our results warrant further studies on these and some related compounds as candidate neurotoxins causing Parkinson's disease." 01/01/2014 - "Mental disturbances in Parkinson's disease and related disorders: the role of excitotoxins."

Related Drugs and Biologics

1.	Amyloid (Amyloid Fibrils)
2.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
3.	Kainic Acid (Kainate)
4.	N-Methylaspartate (NMDA)
5.	Peptides
6.	Quinolinic Acid
7.	Oxidopamine (6 Hydroxydopamine)
8.	Venoms
9.	1-Methyl-4-phenylpyridinium (1 Methyl 4 phenylpyridinium)
10.	Sodium Glutamate (Accent)

Related Therapies and Procedures

1.	Injections
2.	Denervation
3.	Transplants (Transplant)
4.	Intranasal Administration
5.	Therapeutics