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Nitroglycerin (Dynamite)

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A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.

Also Known As:

Dynamite; Glyceryl Trinitrate; Sustak; Nitro-Bid; Nitro-Dur; Nitrol; Nitrostat; Transderm Nitro; Tridil; Anginine; Gilustenon; Nitrangin; Nitrocard; Nitroderm; Nitroderm TTS; Nitroglyn; Nitrolan; Nitrong; Nitrospan; Perlinganit; Susadrin; Sustac; Sustonit; Trinitrin; Trinitrolong; Nitro Bid; Nitro Dur; NitroBid; NitroDur; Trinitrate, Glyceryl; 1,2,3-Propanetriol, trinitrate

Networked: 3875 relevant articles (397 outcomes, 550 trials/studies)

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Drug Context: Research Results

Experts

1.	Olesen, J: 18 articles (11/2010 - 06/2000)
2.	Nappi, Giuseppe: 12 articles (01/2015 - 01/2003)
3.	Tassorelli, Cristina: 12 articles (01/2015 - 01/2003)
4.	Graham, Charles H: 12 articles (02/2014 - 09/2002)
5.	Greco, Rosaria: 11 articles (01/2015 - 01/2003)
6.	Sandrini, Giorgio: 10 articles (01/2014 - 01/2003)
7.	Nappi, G: 10 articles (03/2010 - 01/2000)
8.	Bath, Philip M W: 9 articles (02/2015 - 06/2006)
9.	Higashi, Yukihito: 9 articles (04/2007 - 05/2002)
10.	Sprigg, Nikola: 8 articles (01/2016 - 11/2006)

Related Diseases

1.	Angina Pectoris 02/01/1992 - "The nitroglycerin patches administration was effective for stable angina pectoris with excellent patient's compliance." 01/01/1988 - "Nitroglycerin patch demonstrated significant improvement of exercise tolerance comparing to placebo, in exercise time to the onset of angina pectoris and ST-segment depression of greater than or equal to 1.0 mm (+45% and +47%), in maximum walking time (+13%), as well as in diminished severity of maximum angina (-38%), in lower maximal ST-segment depression (-32%) and in faster recovery of ST-depression 3 and 6 minutes after the test (-28% and -44%). " 01/01/1988 - "The study demonstrated the efficacy of sustained-release buccal nitroglycerin in effort-induced stable angina pectoris, and an absence of (+) tolerance to the therapeutic effects of this mode of nitrate administration." 01/01/1988 - "The efficacy of a 2.5 mg sustained-release buccal nitroglycerin preparation given 8-hourly in effort-induced stable angina pectoris was investigated by means of graded exercise testing in 15 patients. " 01/01/1986 - "The efficacy of a once daily transdermally applied nitroglycerin system and of sustained release nitroglycerin capsules was assessed by ergometer stress testing in 12 patients with stable angina pectoris in a double-blind crossover study. "
2.	Pain (Aches) 07/01/2002 - "Women who completed this study experienced significant improvement in their overall pain and pain with sexual activity after nitroglycerin use. " 08/01/2001 - "Our study attempts to test the hypothesis that topical nitroglycerin applied to the perianal region is beneficial in reducing pain after hemorrhoidectomy. " 05/01/2001 - "A statistically significant reduction of pain was achieved by excision if compared with incision or conservative treatment with glyceryl trinitrate (p<0.001), and by conservative treatment with glyceryl trinitrate if compared with incision (p<0.01 on the 4th day of follow-up. " 05/01/2001 - "Nitroderm TTS bands effectively reduced anal resting pressure and relieved pain in patients with high preoperative anal resting pressure." 08/01/1999 - "Topical glyceryl trinitrate produces a successful internal sphincterotomy, which resulted in long-term healing of 59 percent of chronic anal fissures and significant improvement in pain. "
3.	Spasm (Spasms) 04/01/1980 - "The risk of serious complications (such as arrhythmias) is very low provided that an induced spasm is immediately relieved by intracoronary injection of nitroglycerin. " 05/01/1983 - "Intravenous nitroglycerin was effective in treating the second episode of coronary artery spasm. " 05/01/1981 - "These results demonstrate that nitroglycerin ointment provides effective, long-lasting protection against angina due to coronary spasm." 09/01/2006 - "We studied the efficacy of systemic versus local nitroglycerin in relieving radial artery spasm caused by needle entry resulting in failed cannulation. " 01/01/2002 - "Coronary angiography showed severe coronary spasm of the left anterior descending and left circumflex arteries; the spasm was relieved promptly by nitroglycerin. "
4.	Myocardial Infarction 03/01/1989 - "Nitroglycerin is an effective agent for reducing preload and afterload in acute myocardial infarction. " 07/01/1990 - "Thus transdermal nitroglycerin is a safe and effective treatment of acute myocardial infarction with signs of left ventricular failure when an intravenous nitroglycerin infusion cannot be properly implemented." 03/15/1998 - "We therefore performed a randomized double-blind, placebo-controlled trial designed to investigate the long-term (6 month) efficacy of intermittent transdermal nitroglycerin patches on LV remodeling in 291 survivors of acute myocardial infarction. " 03/07/1989 - "However, in this study, injection of nitroglycerin, 0.2 mg, into the totally or subtotally occluded coronary artery either released the occlusion or improved the patency in 13 of the 69 patients (18.8%) with acute transmural myocardial infarction in whom coronary arteriography was performed within 4.0 +/- 1.9 hours of the onset of symptoms. " 03/01/1999 - "[Improved detection of fill-in using sublingual nitroglycerin in technetium-99m tetrofosmin exercise/rest single photon emission computed tomography one day protocol for old myocardial infarction]."
5.	Chest Pain (Chest Pains) 08/01/1976 - "As the brachial artery pressure rose in one patient, chest pain and marked ST-segment elevation occurred which were relieved by nitroglycerin. " 01/01/1994 - "Six patients had a significant improvement of symptoms confirmed by a reduced incidence of chest pain and decreased used of nitroglycerin. " 01/01/1994 - "Nitroglycerin was beneficial in 41 patients (49%; 95% CI, 38-60%): 37 patients (45%) had relief or reduction in the severity of chest pain and 4 patients (5%) had other beneficial effects. " 04/01/1991 - "With evidence of altered vasomotor tone when compared to no therapy however it was beneficial in terms of reduction in chest pain and requirement for glyceryl trinitrate during daily life.(ABSTRACT TRUNCATED AT 250 WORDS)" 02/01/1986 - "When compared to the MED patients at time of follow-up, successful PTCA patients experienced less angina (13% vs 47%; p = 0.003), used less nitroglycerin (25% vs 73%, p = 0.003), were hospitalized less often for chest pain (8% vs 31%; p = 0.02), and subjectively felt their condition had improved (96% vs 20%; p less than 0.001). "

Related Drugs and Biologics

1.	Diltiazem (Cardizem)
2.	Nifedipine (Adalat)
3.	Nitroglycerin (Dynamite)
4.	Verapamil (Calan)
5.	Nitrates
6.	Vasopressins (Vasopressin)
7.	Nitric Oxide (Nitrogen Monoxide)
8.	Oxygen
9.	Nitroprusside (Sodium Nitroprusside)
10.	Isosorbide Dinitrate (Isordil)

Related Therapies and Procedures

1.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
2.	Catheters
3.	Transplants (Transplant)
4.	Oral Sprays
5.	Sclerotherapy