Vasopressins (Vasopressin)

Antidiuretic hormones released by the NEUROHYPOPHYSIS of all vertebrates (structure varies with species) to regulate water balance and OSMOLARITY. In general, vasopressin is a nonapeptide consisting of a six-amino-acid ring with a cysteine 1 to cysteine 6 disulfide bridge or an octapeptide containing a CYSTINE. All mammals have arginine vasopressin except the pig with a lysine at position 8. Vasopressin, a vasoconstrictor, acts on the KIDNEY COLLECTING DUCTS to increase water reabsorption, increase blood volume and blood pressure.

Also Known As:

Networked: 5571 relevant articles (300 outcomes, 681 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gheorghiade, Mihai: 53 articles (10/2015 - 06/2003)
2.	Wenzel, Volker: 43 articles (01/2012 - 04/2002)
3.	Konstam, Marvin A: 32 articles (10/2015 - 04/2005)
4.	Russell, James A: 31 articles (09/2014 - 03/2002)
5.	Walley, Keith R: 28 articles (09/2014 - 03/2002)
6.	Wenzel, V: 28 articles (02/2007 - 01/2000)
7.	Lindner, Karl H: 26 articles (11/2008 - 04/2002)
8.	Zannad, Faiez: 25 articles (10/2015 - 05/2005)
9.	Maggioni, Aldo P: 24 articles (10/2015 - 03/2007)
10.	Swedberg, Karl: 24 articles (10/2015 - 05/2005)

Related Diseases

1.	Heart Failure 11/13/2001 - "Inhibiting the action of vasopressin may be beneficial in patients with heart failure. " 09/01/1986 - "Vasopressin infusion, however, produced significantly greater increases in peripheral resistance in animals with heart failure than in controls. " 05/01/2008 - "Based on data from available clinical trials, vasopressin antagonists may offer a new treatment option for patients with congestive heart failure. " 01/01/2010 - "In line with previous clinical reports, our study on hypothalami of chronic heart failure patients revealed a significant increase in the relative profile density (+29%) of vasopressin-positive neurons in the hypothalamic supraoptic nucleus. " 03/01/2005 - "The following is a review of current experimental and clinical studies using vasopressin antagonists and their potential role in the treatment of heart failure."
2.	Hemorrhage 07/01/2010 - "Efficacy of bleeding control using a large amount of highly diluted vasopressin in laparoscopic treatment for interstitial pregnancy." 06/01/1974 - "However, arteriography proved very helpful in locating the site of bleeding and vasopressin infusion can still be recommended to decrease intraluminal hemorrhage and improve the general condition of the patient before undergoing operation." 09/01/1991 - "In both cases, the injection of dilute vasopressin paracervically when coupled with operative hysteroscopy was quite effective in determining the cause of the bleeding and was instrumental in avoiding major operative procedures. " 07/01/1988 - "Control of bleeding was not improved with higher doses of vasopressin. " 12/01/1992 - "Intra-arterial vasopressin infusion appears to be an effective method for controlling bleeding from a stapled intestinal anastomosis and can avert the need for reoperation."
3.	Heart Arrest (Cardiac Arrest) 10/01/2005 - "Although there is a suggestion that vasopressin may be effective in treatment of asystole, the evidence for this arises from a subgroup analysis that should be viewed as hypothesis generating. " 01/01/2012 - "Prior meta-analyses-reported results of randomised controlled trials (RCTs) published between 1997 and 2004 failed to show any vasopressin-related benefit in cardiac arrest. " 01/01/2012 - "Vasopressin for cardiac arrest: meta-analysis of randomized controlled trials." 04/01/2009 - "No veterinary clinical trials have been performed using vasopressin in cardiopulmonary arrest. " 10/01/2005 - "Prospective, randomized, controlled trials that evaluated efficacy or safety endpoints of vasopressin in the management of cardiac arrest were included. "
4.	Shock 09/01/2012 - "The major hemodynamic difference between the two groups was a significant reduction in heart rate in the patients treated with vasopressin (P <.0001), and this was most pronounced in the less severe shock stratum (treatment × shock stratum interaction, P =.03). " 01/01/2008 - "The use of vasopressin is an alternative therapy for vasodilatory shock with better outcome. " 04/01/2008 - "Any therapeutic efficacy of infusion of vasopressin for post-cardiotomy shock in children is likely due to reasons other than physiologic replacement." 08/01/2007 - "Examples of types of shock resistant to catecholamine pressors in which exogenous vasopressin was effective in restoring arterial pressure continued to accumulate. " 06/01/2000 - "Vasopressin effective in reversing catecholamine-resistant vasodilatory shock."
5.	Septic Shock (Toxic Shock Syndrome) 06/01/2013 - "We found a significant reduction of the mortality rate in septic shock patients who received vasopressin compared with PMX. " 09/01/2012 - "Vasopressin treatment in septic shock is associated with a significant reduction in heart rate but no change in cardiac output or other measures of perfusion. " 10/01/2009 - "However, vasopressin may be beneficial in the less severe septic shock subgroup. " 02/01/2009 - "However, vasopressin may be beneficial in the less severe septic shock subgroup. " 12/01/2004 - "There is growing evidence that vasopressin infusion in septic shock is safe and effective. "

Related Drugs and Biologics

1.	tolvaptan
2.	Epinephrine (Adrenaline)
3.	terlipressin
4.	Deamino Arginine Vasopressin (Desmopressin)
5.	Somatostatin (Somatotropin Release-Inhibiting Factor)
6.	Nitroglycerin (Dynamite)
7.	Sodium
8.	Norepinephrine (Noradrenaline)
9.	Hormones
10.	Octreotide (Sandostatin)

Related Therapies and Procedures

1.	Cardiopulmonary Resuscitation (CPR)
2.	Resuscitation
3.	Sclerotherapy
4.	Cardiopulmonary Bypass (Heart-Lung Bypass)
5.	Intravenous Infusions