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Isosorbide Dinitrate (Isordil)

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A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.

Also Known As:

Isordil; Cardonit 40; Dilatrate; Iso-Bid; Isodinit; Isoket; Isoket Retard-120; Isomak R; Isotrate; Nitrosorbide; Sorbitrate; Sorbonit; Dinitrate, Isosorbide; Iso Bid; IsoBid; Isoket Retard 120; Isoket Retard120; D-Glucitol, 1,4:3,6-dianhydro-, dinitrate

Networked: 1027 relevant articles (124 outcomes, 178 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Taylor, Anne L: 14 articles (12/2014 - 06/2002)
2.	Worcel, Manuel: 14 articles (12/2014 - 06/2002)
3.	Cohn, Jay N: 12 articles (12/2014 - 06/2002)
4.	Tam, S William: 11 articles (12/2014 - 12/2005)
5.	Sabolinski, Michael L: 10 articles (08/2012 - 12/2005)
6.	Yancy, Clyde W: 7 articles (12/2014 - 06/2002)
7.	Ghali, Jalal K: 6 articles (08/2012 - 12/2005)
8.	A-HeFT Investigators: 5 articles (08/2012 - 06/2002)
9.	Ziesche, Susan: 5 articles (08/2012 - 06/2002)
10.	Nakagawa, Keigo: 5 articles (12/2002 - 02/2002)

Related Diseases

1.	Heart Failure 12/01/1976 - "Isosorbide dinitrate, in conjunction with more usual therapeutic measures, has proved clinically beneficial in the treatment of heart failure." 08/01/1978 - "Isosorbide dinitrate effectively reduces left ventricular filling pressure in the resting patient with congestive cardiac failure but produces a more comprehensive improvement in left ventricular performance during exercise." 05/01/2005 - "The African-American Heart Failure Trial (AHeFT) evaluated the efficacy of a fixed dose combination of isosorbide dinitrate and hyrdalazine compared with placebo in black patients with advanced self-identified heart failure. " 07/01/1985 - "Role of isosorbide dinitrate in management of chronic congestive heart failure." 04/01/1983 - "Improved exercise capacity and differing arterial and venous tolerance during chronic isosorbide dinitrate therapy for congestive heart failure."
2.	Angina Pectoris 11/01/1994 - "Efficacy of eccentric dosing with sustained-release isosorbide dinitrate in patients with angina pectoris." 03/01/1991 - "A quadruple blind randomized cross-over study evaluated the therapeutic efficacy of twice a day long acting sustained release isosorbide dinitrate (SRISDN) in comparison with 4 times daily of the short acting isosorbide dinitrate in 18 patients with stable angina pectoris (NYHA class II-III) with a positive exercise treadmill test. " 01/01/2012 - "Meta-Analysis of Randomized Controlled Trials on the Efficacy of Di'ao Xinxuekang Capsule and Isosorbide Dinitrate in Treating Angina Pectoris." 01/01/2000 - "[Evaluation of antianginal efficacy of long-term therapy with low dose isosorbide dinitrate in patients with stable angina pectoris]." 01/01/1992 - "[The clinical evaluation of the efficacy of Isoket in patients with vasospastic stenocardia]."
3.	Spasm (Spasms) 12/01/1985 - "A selective right coronary opacification showed complete occlusion at the junction of segments 1 and 2. An intracoronary injection of isosorbide dinitrate relieved a coronary spasm and allowed a complete visualization of the right coronary artery. " 06/01/2012 - "Coronary angiogram revealed the severe and simultaneous spasm of three major epicardial arteries, which was promptly relieved by an intracoronary administration of isosorbide dinitrate. " 07/10/2007 - "Isosorbide dinitrate was injected immediately, and the provoked spasm was soon relieved. " 03/01/1992 - "Coronary artery spasm was promptly relieved by intracoronary isosorbide dinitrate infusion. " 01/01/2013 - "The spasm was reversed by administration of 2 mg of intracoronary isosorbide dinitrate. "
4.	Myocardial Ischemia (Ischemic Heart Diseases) 01/01/1981 - "According to the pre- and post-exercise bicycle ergometer testing estimated by triaxicardiometry, isosorbide dinitrate caused a significant reduction of subendocardial myocardial ischemia." 09/01/1991 - "[Isosorbide dinitrate ameliorates myocardial ischemia after development of collateral function in a canine model]." 03/01/1989 - "Isosorbide dinitrate ameliorates myocardial ischemia after development of collateral function in a canine model." 08/01/1995 - "This study assessed invasively the hemodynamics during supine rest before and for 50 min after peroral 30 mg isosorbide dinitrate (ISDN) in 16 patients with stable ischemic heart disease; 8 previously untreated patients (NT group) and 8 patients treated asymmetrically b.i.d. " 02/01/1992 - "This study investigates the systemic hemodynamic effects of intravenous Isosorbidi Dinitras, Isoket (ISDN) in 20 patients with coronary arterial disease to test the validity of the hypothesis concerning the relief of myocardial ischemia. "
5.	Unstable Angina 09/01/1995 - "Comparison of the therapeutic efficacy of continuous and intermittent injection of isosorbide dinitrate: a randomized study on unstable angina." 09/01/1995 - "Therapeutic efficacy of intermittent and continuous injection of isosorbide dinitrate (ISDN) was compared in 22 patients (mean age 64 +/- 10, 18 males and 4 females) with unstable angina at rest. " 05/01/1998 - "In a single-center prospective trial, 72 consecutive patients with unstable angina accompanied by typical ST-segment depression on electrocardiogram were randomly assigned to receive isosorbide dinitrate either as repeated intravenous boluses or as sublingual sprays while being delivered to the hospital by a mobile intensive care unit. " 01/01/1988 - "The aim of this study was to explore the capability of isosorbide dinitrate (ISDN) infusion to quench the 'hot phase' of unstable angina, a real cardiological emergency. " 09/01/2008 - "Irradiated NO donor isoket produced better normalizing effect on blood viscosity and erythrocyte deformability in patients with unstable angina."

Related Drugs and Biologics

1.	Hydralazine (Apresoline)
2.	Nifedipine (Adalat)
3.	Nitroglycerin (Dynamite)
4.	Nicorandil (SG 75)
5.	Verapamil (Calan)
6.	Propranolol (Inderal)
7.	Diltiazem (Cardizem)
8.	Enalapril
9.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
10.	Vasodilator Agents (Vasodilators)

Related Therapies and Procedures

1.	Intravenous Infusions
2.	Aftercare (After-Treatment)
3.	Sublingual Administration
4.	Oral Sprays
5.	Intra-Aortic Balloon Pumping