Factor X (Stuart Factor)

Storage-stable glycoprotein blood coagulation factor that can be activated to factor Xa by both the intrinsic and extrinsic pathways. A deficiency of factor X, sometimes called Stuart-Prower factor deficiency, may lead to a systemic coagulation disorder.

Also Known As:

Networked: 408 relevant articles (9 outcomes, 29 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Marte, Filippo: 11 articles (12/2011 - 05/2009)
2.	Patanè, Salvatore: 11 articles (12/2011 - 05/2009)
3.	Peyvandi, Flora: 5 articles (10/2015 - 10/2002)
4.	Wojtukiewicz, Marek Z: 4 articles (05/2014 - 01/2012)
5.	Menegatti, Marzia: 3 articles (10/2015 - 06/2009)
6.	Yang, Likui: 3 articles (11/2014 - 07/2005)
7.	Rezaie, Alireza R: 3 articles (11/2014 - 07/2005)
8.	Kisiel, Walter: 3 articles (05/2014 - 04/2012)
9.	Ostrowska-Cichocka, Krystyna: 3 articles (05/2014 - 04/2012)
10.	Sierko, Ewa: 3 articles (05/2014 - 04/2012)

Related Diseases

1.	Amyloidosis 09/01/1993 - "We suggest that the possibility of a spontaneous factor X recovery must be considered when evaluating efficacy of therapeutic agents in amyloidosis." 12/07/1992 - "Initially, factor X infusion studies showed a normal recovery, but when amyloidosis became overt the recovery decreased to 0%. " 06/01/1988 - "A reproducible model for the study of factor X kinetics in AA amyloidosis." 02/01/2014 - "Acquired factor X (FX) deficiency unrelated to amyloidosis is a rare disorder in which an anti-FX antibody is infrequently detected. " 03/01/2010 - "Systemic light-chain (AL) amyloidosis may be associated with acquired factor X (FX) deficiency and optimal management of this coagulopathy is unknown. "
2.	Factor X Deficiency 01/01/2005 - "Genetic analysis of hereditary factor X deficiency in a French patient of Sri Lankan ancestry: in vitro expression study identified Gly366Ser substitution as the molecular basis of the dysfunctional factor X." 11/01/1988 - "Congenital factor X (Stuart-Prower factor) deficiency: a family study." 07/01/2015 - "Inherited Factor X (Stuart-Prower Factor) deficiency and its management." 01/01/2015 - "A novel factor X gene mutation Val (GTC) 384Ala (GCC) in a Chinese family resulting in congenital factor X deficiency." 11/01/2013 - "Femur fracture in a woman with severe factor X deficiency - an experience using factor X concentrate in surgery."
3.	Hemorrhage 01/01/2016 - "The most frequent and severe bleeding complications occurred in patients with factor X levels below 10%. " 10/01/2015 - "Direct sequencing of the factor X gene (F10) identified two different mutations: the novel 33 bp in-frame deletion p.Thr176_Gln186, c.526_558del, which seems to be associated with milder bleeding symptoms and the c.785G>A, p.Gly262Asp missense mutation (previously reported as Gly222Asp), which is associated with severe bleeding symptoms. " 10/01/2015 - "Congenital factor X (FX) deficiency is a rare bleeding disorder inherited as an autosomal recessive trait with an incidence of 1 : 500 000-1 000 000. " 03/01/2015 - "Congenital factor X (FX) deficiency is a rare coagulation disorder of autosomal recessive inheritance, characterized by bleeding of variable severity. " 01/01/2014 - "The patient developed severe gastrointestinal bleeding as a result of a significant decrease of factor X activity. "
4.	Venous Thrombosis (Deep-Vein Thrombosis) 04/01/2006 - "In conclusion, APTT-based assays, but not direct factor X activation-based assays, effectively detect the risk for venous thrombosis independent of FVL. " 06/01/2001 - "Factor X levels, polymorphisms in the promoter region of factor X, and the risk of venous thrombosis." 02/16/2007 - "This exosite is physiologically highly relevant for the recognition and inhibition of factor X/Xa by macromolecular substrates and provides a structural motif for the development of a new class of inhibitors for the treatment of deep vein thrombosis and angioplasty." 04/01/2006 - "One hundred ninety-seven subjects with a history of venous thrombosis and 211 controls were explored using 3 APCR assays, the original APTT-based assay (test A), an APTT-based assay with factor V depleted plasma pre-dilution (test B) and a direct factor X activation-based assay with the same pre-dilution (test C). " 05/01/2003 - "Factor X inhibitors are also being evaluated for use in the treatment of the acute coronary syndromes, pulmonary embolism and deep vein thrombosis. "
5.	Disease Susceptibility (Diathesis) 10/01/1979 - "A case of severe haemorrhagic diathesis due to acquired deficiency of factor X (both immunologically and in procoagulant activity) is presented. " 12/01/2010 - "Factor X Umuahia: a severe bleeding diathesis associated with a novel mutation." 07/01/2004 - "The mutations in factor X, in this part of the world are most probably not the one, which would cause a severe bleeding diathesis." 01/01/2003 - "In utero transplantation of wild-type fetal liver cells rescues factor X-deficient mice from fatal neonatal bleeding diatheses." 12/01/1982 - "From these experiments, it is inferred that normal activation of factor X in plasma due to dilute thromboplastin requires factors VII, IX and VIII. An alternative extrinsic pathway that involves factors VII, IX, and VIII may be a major physiologic extrinsic pathway, and this pathway may help to explain the clinical observations of bleeding diatheses in patients deficient in factors IX or VIII."

Related Drugs and Biologics

1.	Thrombin
2.	Thromboplastin (Tissue Factor)
3.	Fibrinogen (Factor I)
4.	Factor Xa (Coagulation Factor Xa)
5.	prothrombin complex concentrates (PPSB)
6.	Amyloid (Amyloid Fibrils)
7.	Dacarbazine (DIC)
8.	fondaparinux (Arixtra)
9.	Prothrombin (Factor II)
10.	Factor IX (PTC)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Endarterectomy (Thromboendarterectomy)
3.	Splenectomy
4.	Catheters
5.	Angioplasty (Angioplasty, Transluminal)