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Thrombin

An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.

Also Known As:

Ethicon Brand of Thrombin; Jones Brand of Thrombin; Park Davis Brand of Thrombin; Pfizer Brand of Thrombin; Thrimbin-JMI; Thrombinar; Thrombostat; alpha-Thrombin; beta,gamma-Thrombin; beta-Thrombin; gamma-Thrombin; Thrimbin JMI; ThrimbinJMI; Thrombin Ethicon Brand; Thrombin Jones Brand; Thrombin Pfizer Brand; Thrombase

Networked: 7252 relevant articles (338 outcomes, 830 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Xi, Guohua: 36 articles (01/2016 - 01/2002)
2.	Keep, Richard F: 34 articles (01/2016 - 01/2002)
3.	Undas, Anetta: 33 articles (10/2015 - 01/2002)
4.	Hua, Ya: 31 articles (01/2016 - 01/2002)
5.	Levi, Marcel: 27 articles (03/2015 - 03/2002)
6.	van der Poll, Tom: 25 articles (10/2015 - 05/2002)
7.	Lockwood, Charles J: 22 articles (10/2015 - 09/2002)
8.	ten Cate, Hugo: 22 articles (08/2015 - 05/2002)
9.	Rosing, Jan: 22 articles (07/2013 - 03/2002)
10.	Heemskerk, Johan W M: 21 articles (06/2015 - 12/2002)

Related Diseases

1.	Hemorrhage 07/01/2008 - "Preliminary data suggest that some of these tests, notably thromboelastography and the thrombin generation test, may be helpful for predicting the individual bleeding risk and for providing individually tailored treatment regimens. " 12/05/2015 - "Global coagulation assays (thrombin generation, thromboelastography) reflect the interaction between procoagulant factors, anticoagulant factors, platelets, and the fibrinolytic system and show promise for assessing bleeding risk and guiding therapy. " 09/01/2010 - "Newer Xa and thrombin inhibitors enjoy greater efficacy with equal or higher bleeding rates. " 06/01/2002 - "Our experience demonstrates that endoscopic therapy with thrombin appears safe and can be effective in the management of gastric variceal bleeding." 04/01/1999 - "Thrombin is effective in arresting bleeding from gastric variceal hemorrhage."
2.	Thrombosis (Thrombus) 02/01/2012 - "It also has a potent inhibitory effect on thrombin-induced platelet aggregation, making it effective in preventing both venous and arterial thrombosis. " 01/01/2003 - "While the in vitro results with ODN 2 were consistent with thrombus imaging, the rapid clearance of ODN 2 from circulation, combined with slow mass transfer in the clot, seem to work against in vivo thrombin-dependent imaging or washout analysis." 11/01/2008 - "ELISA and immunohistochemistry assay were used to study the improved thrombus selectivity of SFH and the results showed that SFH, compared with SAK, displayed higher affinity for thrombin and thrombin-rich thrombus. " 07/01/2015 - "Ecotin-RR was more effective in inhibiting thrombin than ecotin-WT. Both ecotins presented similar mechanisms of anticoagulation activity and were able to decrease thrombus formation. " 07/30/2010 - "These data show for the first time that: (i) STIM1 and Orai1 jointly contribute to GPVI-induced SOCE, procoagulant activity, and thrombus formation; (ii) a compensating Ca(2+) entry pathway is effective in the additional presence of thrombin; (iii) platelets contain two mechanisms of Ca(2+) entry and PS exposure, only one relying on STIM1-Orai1 interaction."
3.	False Aneurysm (Pseudoaneurysm) 11/01/2000 - "The good results from this study showed that ultrasound-guided thrombin injection is an effective method for the treatment of post-catheterization false aneurysms. " 01/01/2011 - "Femoral pseudoaneurysm closure with a low dose of thrombin is a valid and beneficial treatment. " 05/20/2004 - "Based on the good results reported in the literature and our own experience, we suggest that ultrasound-guided injection of thrombin should be the treatment of choice for femoral pseudoaneurysms." 12/16/2000 - "[Ultrasound guided percutaneous thrombin injection for treatment of a pseudoaneurysm after inguinal or brachial catheterization; good results in 14 patients]." 10/01/2000 - "Preliminary evidence suggests that sonographically guided percutaneous thrombin injection is a safe and effective method of treatment for iatrogenic pseudoaneurysms and offers significant advantages over conventional sonographically guided compression."
4.	Stroke (Strokes) 01/01/2012 - "Amongst these new agents, the recently approved direct thrombin inhibitor dabigatran provides effective stroke prevention with a significant reduction of ICH, and enables clinicians to tailor the dose according to age and haemorrhagic risk." 10/01/2009 - "Low levels of TAT are not associated with an increase in haemorrhagic complications after t-PA, indicating that the combination of thrombin blockers and t-PA could be a safe and effective treatment for ischaemic stroke in the future." 03/01/2001 - "Some statins have been shown to improve endothelial function and vasodilation and to normalize thrombin formation, which may be among the mechanisms involved in both coronary event and stroke prevention." 10/01/2015 - "Coagulation factor XII genetic variation, ex vivo thrombin generation, and stroke risk in the elderly: results from the Cardiovascular Health Study." 10/01/2013 - "However, there are few studies on thrombin generation using CAT in patients with manifest ischemic stroke, particularly in patients with cardioembolic stroke not yet on anticoagulation. "
5.	Venous Thromboembolism 01/01/2005 - "The THRombin Inhibitor in VEnous thromboembolism (THRIVE) clinical trial programme has demonstrated that this agent is as effective as standard therapy for the acute treatment (THRIVE Treatment) and secondary prevention (THRIVE lll) of VTE events and is well tolerated when used for 6 months or over extended periods up to 1.5 years. " 03/15/2002 - "Low-molecular-weight and unfractionated heparins are frequently used to treat venous thromboembolism, but it is not known whether they are equally effective in inhibiting in vivo generation of thrombin. " 10/01/2015 - "In patients with documented venous thromboembolism, increased thrombin generation values are seen in those patients at greatest risk for recurrence. " 02/01/2014 - "Inherited anti-thrombin deficiency is an autosomal dominant disorder which is associated with increased risk for venous thromboembolism (VTE). " 02/01/2012 - "The oral direct thrombin inhibitor dabigatran effectively prevents arterial and venous thromboembolism using fixed doses without the need for adjustment according to laboratory results. "

Related Drugs and Biologics

1.	Heparin (Liquaemin)
2.	Warfarin (Coumadin)
3.	ximelagatran (Exanta)
4.	Hirudins
5.	bivalirudin (Angiomax)
6.	Factor Xa (Coagulation Factor Xa)
7.	Fibrinogen (Factor I)
8.	Collagen
9.	argatroban (MPQA)
10.	Fibrin

Related Therapies and Procedures

1.	Stents
2.	Transplants (Transplant)
3.	Angioplasty (Angioplasty, Transluminal)
4.	Knee Replacement Arthroplasty (Total Knee Replacement)
5.	Arthroplasty