Anticoagulants

01/01/2014 - "Oral anticoagulants (OAC) are highly effective in preventing stroke, and there are evidence-based guidelines for the optimal use of OAC in patients with AF. "
09/01/2008 - "Antiplatelet therapy is highly effective in reducing the risk of recurrent vascular events and is recommended over oral anticoagulants for non-cardioembolic stroke. "
02/01/2000 - "Further studies examining the efficacy of anticoagulants in different stroke subgroups will be necessary in order to clarify optimal clinical practice."
10/15/2011 - "Our findings suggest important opportunities for practice-level improvement in stroke prevention for outpatients with AF and define a benchmark treatment rate before the introduction of newer anticoagulant agents."
12/01/2009 - "Anticoagulants are very effective for stroke prevention in patients with AF, overall a 64% relative risk reduction. "

01/01/2013 - "Novel oral anticoagulants appear as a very promising treatment option for atrial fibrillation."
04/01/2009 - "Oral anticoagulants (OA) are effective in the prevention of cerebrovascular events among patients with atrial fibrillation (AF). "
01/01/2016 - "Meta-Analysis of Renal Function on the Safety and Efficacy of Novel Oral Anticoagulants for Atrial Fibrillation."
05/05/2014 - "Due to improved implementation of guidelines, new scoring approaches to improve risk categorisation, and introduction of novel oral anticoagulants, medical management of patients with atrial fibrillation (AF) is continuously improving. "
01/01/2014 - "Consistency of safety and efficacy of new oral anticoagulants across subgroups of patients with atrial fibrillation."

08/01/2012 - "However, like other anticoagulants, it can cause severe bleeding complications and lacks a specific antidote with proven efficacy. "
10/01/2010 - "The widespread use of antiplatelet and anticoagulant agents has resulted in a significant reduction in morbidity and mortality but has also increased the risk for bleeding complications. "
03/01/2009 - "In order to optimize patient outcomes, anticoagulants should ideally combine high antithrombotic efficacy with a low risk of bleeding. "
01/01/1995 - "Although anticoagulants are beneficial in the prevention and management of many thromboembolic disorders, they can cause serious bleeding. "
02/01/2014 - "We evaluated the benefit-to-harm ratio of the use of newer anticoagulants as thromboprophylaxis in patients undergoing major orthopaedic surgery using the likelihood of being helped or harmed (LHH), and assessed the effects of variation in the definition of major bleeding on the results. "

07/01/2012 - "Oral anticoagulants offer the best maternal protection against thrombosis, but their use might be associated with an appreciable risk of fetal malformations and pregnancy loss. "
10/01/2007 - "Oral anticoagulants are the best available and most effective treatment for the secondary prevention of recurrent venous or arterial thrombosis. "
09/01/2010 - "Once proven well tolerated and effective for treating thrombosis, these new oral anticoagulants should next be studied for treating HIT."
03/01/2002 - "In addition, these affinity improved hTFAA variants are more potent anticoagulants and have increased antithrombotic activity relative to hTFAA in an ex vivo flow chamber model of thrombosis. "
05/01/2013 - "Preservation therapy using anticoagulants for a long duration was effective for controling the of clinical symptom of thrombosis. "

09/01/2009 - "Since it has been shown that most venous thromboembolism events occur following hospital discharge, these new anticoagulants may result in very significant reduction in the overall incidence of venous thromboembolism events."
02/01/2015 - "Objective diagnosis and treatment are important in optimizing clinical outcomes in patients with venous thromboembolism (VTE), and anticoagulants are the mainstay of treatment. "
11/01/2011 - "In the last decade, parenteral anticoagulants have proven to be effective in the prevention of venous thromboembolism (VTE) in patients admitted to hospitals. "
04/01/2013 - "After reports from observational studies suggesting an association between acutely ill medical patients and venous thromboembolism (VTE), interventional trials with anticoagulants drugs have demonstrated a significant reduction of VTE during and immediately after hospitalisation. "
06/01/2007 - "Clinical trials have repeatedly demonstrated superior efficacy over other anticoagulants as venous thromboembolism prophylaxis and several cost-effectiveness studies have demonstrated cost savings with this drug."