Autoantibodies

08/01/2013 - "Many autoimmune diseases are associated with a particular set of autoantibodies, which have emerged as highly useful to define and classify disease, predict flares, or monitor efficacy of therapy. "
07/01/2012 - "Autoantibodies may be helpful for the diagnosis of autoimmune diseases, but regular and long follow-up is needed in NHL patients with high levels of autoantibodies."
06/01/2009 - "Due to the overlap in autoantibody profiles in autoimmune diseases, and due to the complexity of MS, multiplex autoantibody profiling approaches are needed to generate a panel of MS-associated autoantibodies with high combined sensitivity and specificity for MS. In recent years, several multiplexing approaches have been applied in MS autoantibody profiling with promising results regarding the generation of a so-called MS-specific autoantibody fingerprint. "
03/01/1997 - "These findings suggest that LBZ may be effective in the treatment of other autoimmune diseases such as lupus erythematosus that are also characterized by the production of autoantibodies from activated B cells. "
08/01/2010 - "Therapy approaches based on lowering levels of pathogenic autoantibodies represent rational, effective, and safe treatment modalities of autoimmune diseases. "

06/15/2013 - "In the present study, treatment methods used for patients suffering from pemphigus vulgaris were not successful in significantly decreasing the circulative autoantibodies levels."
11/01/2010 - "The aim of this study was to determine its expression of desmosomal components and to evaluate its use as a detection tool for circulating autoantibodies in canine pemphigus. "
03/01/2009 - "Although several reports suggest an association between pemphigus and other autoimmune connective tissue disorders, studies that measure non-organ-specific autoantibodies are lacking. "
01/01/2009 - "The aim of the study was to determine the relationship between autoantibodies levels and the extent of both mucosal and skin lesions in 20 patients with pemphigus vulgaris at the time of diagnosis and during follow-up. "
10/01/2007 - "As it is unlikely that desmosomal signaling would occur only in response to pemphigus autoantibodies, these studies suggest that numerous different signaling molecules may play a role in desmosomal homeostasis. "

01/01/1988 - "Also no false-positive results were obtained with 20 sera from systemic lupus erythematosus patients which had high titers of cross-reactive autoantibodies. "
08/01/2004 - "Reduction of pathological autoantibodies may be useful in the treatment of systemic lupus erythematosus (SLE). "
01/01/2012 - "Systemic lupus erythematosus is characterized by dysfunctional clearance of apoptotic debris and the development of pathogenic autoantibodies. "
03/01/2015 - "The objectives of this study were to evaluate the neuropsychiatric involvement in systemic lupus erythematosus (SLE) patients and to detect the autoantibodies associated with them. "
11/01/2014 - "Future studies aimed at elucidating the intersection between autoantibodies generated in the context of systemic lupus erythematosus and the development of HIV-1 bnAbs will further our knowledge of specific roadblocks that hamper the production of bnAbs and, ultimately, inform us on how to implement vaccine strategies to circumvent them. "

09/01/2015 - "In this study, we show that Trex1 (-/-) mice lacking cGAS are completely protected from lethality, exhibit dramatically reduced tissue inflammation, and fail to develop autoantibodies. "
10/01/2013 - "TRA-8 treatment depleted these cell populations and resulted in a significant reduction in inflammation and in the titers of autoantibodies. "
06/23/1992 - "Common features of both diseases are chronic persistence, recurrent exacerbation and remission, the production of autoantibodies, as well as the expression of aberrant HLA-class II molecules on the surface of epithelial cells on the site of inflammation gut. "
08/09/2012 - "Murine studies have suggested that such vascular leak facilitates entry of autoantibodies and may thereby promote joint inflammation. "
01/01/2009 - "The aim of this study was to examine seroconversion and the relationship with age and inflammation of autoantibodies in a large group of patients attending an outpatient rheumatology clinic. "

01/01/2015 - "UsC or UsT ameliorates SLE in the MRL-lpr/lpr mice by significantly reducing lymphoproliferation, proteinuria, lesions (tail) and autoantibodies. "
11/01/1995 - "Previous studies indicate that these autoantibodies are probably not the sole mediator of proteinuria and GVEC damage. "
01/01/2015 - "The levels of proteinuria and anti-dsDNA and anti-ANA autoantibodies were further decreased in Dex + Rh1 group. "
01/01/2015 - "Dex significantly reduced the proteinuria and anti-dsDNA and anti-ANA autoantibodies. "
11/01/2014 - "Mice were followed for weight, autoantibodies titers, blood counts, proteinuria, kidney histology, neurocognitive functions (novel object recognition, staircase, Y-maze and the forced swimming tests) and brain histology. "