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Antinuclear Antibodies

Subscribe to New Research on Antinuclear Antibodies

Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.

Also Known As:

Antibodies, Antinuclear; Antinuclear Antibody; Antinuclear Factor; Anti DNA Antibodies; Antibodies, Anti DNA; Antibodies, Fluorescent Antinuclear; Antibody, Antinuclear; Antinuclear Antibodies, Fluorescent; Factor, Antinuclear; Factors, Antinuclear; Anti-DNA Antibodies; Antibodies, Anti-DNA; Antinuclear Factors; Fluorescent Antinuclear Antibodies

Networked: 3309 relevant articles (58 outcomes, 200 trials/studies)

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Blood Proteins: 4303
    - Serum Globulins: 75
      - Immunoglobulins: 23980
        Antibodies: 92632
        Autoantibodies: 18666
        Antinuclear Antibodies: 3309
        SS-A antibodies: 184
        MIB-1 antibody: 112
        anticentromere antibody: 90
        SS-B antibodies: 80
        antiperinuclear factor: 71
        Jo-1 antibody: 24
        anti-extractable nuclear antigen antibodies: 15
        anti-quadruplex DNA scFv
        deoxyribonucleoprotein antibodies
        mouse 3H9 protein
    - Immunoproteins: 33
      - Immunoglobulins: 23980
        Antibodies: 92632
        Autoantibodies: 18666
        Antinuclear Antibodies: 3309
        SS-A antibodies: 184
        MIB-1 antibody: 112
        anticentromere antibody: 90
        SS-B antibodies: 80
        antiperinuclear factor: 71
        Jo-1 antibody: 24
        anti-extractable nuclear antigen antibodies: 15
        anti-quadruplex DNA scFv
        deoxyribonucleoprotein antibodies
        mouse 3H9 protein
  - Globulins: 334
    - Serum Globulins: 75
      - Immunoglobulins: 23980
        Antibodies: 92632
        Autoantibodies: 18666
        Antinuclear Antibodies: 3309
        SS-A antibodies: 184
        MIB-1 antibody: 112
        anticentromere antibody: 90
        SS-B antibodies: 80
        antiperinuclear factor: 71
        Jo-1 antibody: 24
        anti-extractable nuclear antigen antibodies: 15
        anti-quadruplex DNA scFv
        deoxyribonucleoprotein antibodies
        mouse 3H9 protein

Experts

1.	Shoenfeld, Yehuda: 8 articles (07/2013 - 02/2002)
2.	Fritzler, Marvin J: 7 articles (12/2015 - 11/2007)
3.	Putterman, Chaim: 7 articles (09/2015 - 02/2004)
4.	Ramos-Casals, Manuel: 7 articles (04/2010 - 04/2002)
5.	Martini, Alberto: 6 articles (02/2015 - 08/2003)
6.	Ravelli, Angelo: 6 articles (07/2014 - 08/2003)
7.	Bossuyt, Xavier: 6 articles (04/2014 - 07/2003)
8.	Hansson-Hamlin, Helene: 5 articles (12/2015 - 12/2006)
9.	Mahler, Michael: 5 articles (12/2015 - 01/2012)
10.	Perl, Andras: 5 articles (10/2015 - 01/2005)

Related Diseases

1.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 07/01/2007 - "Immunofluorescence microscopy is superior to fluorescent beads for detection of antinuclear antibody reactivity in systemic lupus erythematosus patients." 09/01/2004 - "To study associations between antinuclear antibodies (ANA) and signs/symptoms in patients with systemic lupus erythematosus (SLE). " 01/01/2002 - "Several excellent animal models for systemic lupus erythematosus are available to study the pathogenetic mechanisms of anti-DNA antibodies, immunological mechanisms for their origin and the influence of susceptibility genes for the development of anti-DNA antibodies. " 08/25/2001 - "The aim of this study is to prepare magnetic poly(2-hydroxyethylmethacrylate) (mPHEMA) beads and to investigate their utility for the removal of anti-DNA antibodies from systemic lupus erythematosus (SLE) patient plasma. " 02/01/1996 - "The ELISA procedure established in this study is showed to be a available method to detect anti-DNA antibodies associated with renal disease in patients with systemic lupus erythematosus."
2.	Proteinuria 05/01/1978 - "Such treated mice had reduced anti-DNA antibodies, reduced proteinuria, and improved survival. " 05/01/1986 - "Similar to our past studies, this treatment resulted in a marked prolongation of survival, decrease in proteinuria, and decrease in serum anti-DNA antibodies compared with untreated littermate controls. " 11/01/2015 - "SMAs 11a and 12b were evaluated for their ability to suppress antinuclear antibody (ANA) generation and consequent kidney pathology in MRL/Lpr mice when administered after the onset of proteinuria. " 04/01/2015 - "The parasitic worm product ES-62 targets myeloid differentiation factor 88-dependent effector mechanisms to suppress antinuclear antibody production and proteinuria in MRL/lpr mice." 10/01/2014 - "Disease was monitored by antinuclear antibody (ANA) production, proteinuria, and renal histology. "
3.	Arthritis (Polyarthritis) 01/01/1991 - "This study presents 8 dogs of German Shepherd breed (6 males, 2 females, 2-5 years of age at onset of the disease) with a lupus like syndrome characterized by febrile polyarthritis, wasting, nephropathy, cutaneous lesions and high positive titres of ANA (antinuclear antibodies) of speckled type. " 09/01/2015 - "Common clinical features in ILE include antinuclear antibody seropositivity, polyarthritis, immunologic manifestations, and hematological disorders. " 11/01/2014 - "In contrast, the allele FCGR2A-H-131 was associated with susceptibility to arthritis and anti-DNA antibodies (p = 0.05 for both). " 09/01/2014 - "These patients were also distinctive as being significantly older, more likely to be male, and less likely to have positive antinuclear antibody titers than other patients with ankle/hindfoot/midfoot complex arthritis. " 07/01/2014 - "Risk factors included sex, age at arthritis onset, disease category, and antinuclear antibody (ANA) status. "
4.	Rheumatic Diseases (Rheumatism) 01/01/2013 - "Indirect immunofluorescence (IIF) is the gold standard method for the detection of antinuclear antibodies (ANA) which are essential markers for the diagnosis of systemic autoimmune rheumatic diseases. " 05/01/2000 - "The facilities to detect antinuclear antibodies (ANA) patterns in patients with systemic rheumatic diseases/connective tissue disorders (CTD) using indirect immunofluorescence (IIF) technique (the gold standard) are sparse; the technique is technically difficult and expensive. " 03/01/2015 - "The study was organized to comparatively analyze automated and visual interpretation of results of IRIF HEp-2 in detection of content antinuclear antibodies in patients with rheumatic diseases. " 01/01/2008 - "The aim of this study was to investigate the types and prevalence of disease-specific antinuclear antibodies (ANAs) and their relationship to rheumatic diseases in the general Japanese population. " 11/01/2015 - "For the serological diagnosis of systemic autoimmune rheumatic diseases, a two-tier approach starting with sensitive antinuclear antibody (ANA) detection by indirect immunofluorescence (IIF) on HEp-2 cells followed by characterization of positive findings with different immunoassays is recommended. "
5.	Rheumatoid Arthritis 03/01/1977 - "Skin immunofluorescence studies are helpful in differential diagnosis when patients with a clinical picture of rheumatoid arthritis present with serum antinuclear antibodies and lupus erythematosus cells. " 07/01/1982 - "Studies of antinuclear antibodies in rheumatoid arthritis." 06/01/2015 - "Systemic examinations revealed hyperglobulinemia, increased blood viscosity, increased antinuclear antibody, increased rheumatoid arthritis particle aggregation, and increased anti-SS-A antibody. " 01/01/2005 - "[immunological and serological tests for diagnosis of rheumatoid arthritis: antinuclear antibodies]." 07/01/1998 - "Examinations of 121 patients with rheumatoid arthritis (RA) included immunological testing for antinuclear antibodies (ANA), lymphocyte blastogenesis test, and leukocyte migration inhibition test and functional cardiological examinations (ECG and EchoCG). "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Antibodies
3.	Rheumatoid Factor
4.	Antigen-Antibody Complex (Immune Complex)
5.	Complement System Proteins (Complement)
6.	Prednisone (Sone)
7.	Anticardiolipin Antibodies
8.	Antigens
9.	Steroids
10.	Urea (Carbamide)

Related Therapies and Procedures

1.	Plasma Exchange
2.	Aftercare (After-Treatment)
3.	Injections
4.	Transplants (Transplant)
5.	Breast Implants (Breast Implant)