Plasma Exchange

Removal of plasma and replacement with various fluids, e.g., fresh frozen plasma, plasma protein fractions (PPF), albumin preparations, dextran solutions, saline. Used in treatment of autoimmune diseases, immune complex diseases, diseases of excess plasma factors, and other conditions.

Also Known As:

Networked: 2654 relevant articles (384 outcomes, 227 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	George, James N: 22 articles (12/2015 - 03/2003)
2.	Vesely, Sara K: 13 articles (12/2014 - 03/2003)
3.	Terrell, Deirdra R: 12 articles (12/2014 - 03/2003)
4.	Guillevin, Loïc: 11 articles (12/2015 - 02/2002)
5.	De Silvestro, Giustina: 9 articles (12/2015 - 01/2007)
6.	Carcillo, Joseph A: 9 articles (05/2015 - 10/2002)
7.	Fujimura, Yoshihiro: 9 articles (01/2014 - 05/2002)
8.	Marson, Piero: 8 articles (12/2015 - 01/2007)
9.	Nakae, Hajime: 8 articles (08/2015 - 01/2002)
10.	Winters, Jeffrey L: 8 articles (06/2015 - 02/2009)

Related Diseases

1.	Thrombotic Thrombocytopenic Purpura 01/01/2002 - "The clinical course of thrombotic thrombocytopenic purpura has dramatically improved after the introduction of plasma-based therapy, including plasma exchange and plasma infusion. " 04/01/1991 - "This study supports the hypothesis that plasma exchange has significantly improved the prognosis of patients with thrombotic thrombocytopenic purpura. " 06/01/1989 - "Laboratory data then were conclusive for a thrombotic thrombocytopenic purpura (Moschcowitz's disease) and therefore the patient was subjected to plasma exchange during seven days: this measure induced rapid and full clinical and laboratory remission. " 08/08/1991 - "Plasma exchange is more effective than plasma infusion in the treatment of thrombotic thrombocytopenic purpura." 12/01/2014 - "Safety and efficacy of cryoprecipitate-poor plasma as a replacement fluid for therapeutic plasma exchange in thrombotic thrombocytopenic purpura: a single center retrospective evaluation."
2.	Myasthenia Gravis 01/01/2002 - "On the other hand,experience from many non-randomised studies suggests that plasma exchange is beneficial in myasthenia gravis. " 05/01/1981 - "Antibody-negative acquired myasthenia gravis: successful therapy with plasma exchange." 08/01/1993 - "Immunoadsorption plasmapheresis is an effective treatment for severe generalised myasthenia gravis of childhood and is superior to plasma exchange with respect to safety." 04/01/2013 - "Plasma exchange (PLEX) is effective in myasthenia gravis (MG), but there are concerns about its safety. " 04/01/1991 - "A short plasma exchange protocol is effective in severe myasthenia gravis."
3.	Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) 01/01/2015 - "Moderate- to high-quality evidence from two small trials shows that plasma exchange provides significant short-term improvement in disability, clinical impairment, and motor nerve conduction velocity in CIDP but rapid deterioration may occur afterwards. " 01/01/2012 - "Moderate to high quality evidence from two small trials showed that plasma exchange provides significant short-term improvement in disability, clinical impairment and motor nerve conduction velocity in CIDP but rapid deterioration may occur afterwards. " 06/01/1995 - "We report 7 patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) who showed significant clinical improvement by plasma exchange (PE). " 01/01/1982 - "It is too early to draw any conclusion from these studies other than that the double-blind study employed here is feasible and should provide information on the efficacy of plasma exchange in CIDP if its effect is prompt and large. " 01/01/2012 - "To evaluate the efficacy of plasma exchange in CIDP. "
4.	Thrombocytopenia (Thrombopenia) 12/01/2002 - "She received early plasma exchange and it markedly improved her thrombocytopenia without sequelae. " 05/01/2009 - "Renal function and thrombocytopenia improved gradually after intensive treatment of plasma exchange (PE) and high-dose steroid therapy. " 10/01/2013 - "US-guided CVC is a safe and effective approach in haematological patients with severe thrombocytopenia requiring urgent cannulation for life support, plasma-exchange, chemotherapy and transfusion." 10/01/2007 - "After three plasma exchanges and four sessions of hemodialysis, the thrombocytopenia improved to the normal range. " 12/01/2002 - "Plasma exchange led to recovery from thrombocytopenia and improvement in renal function. "
5.	Proteinuria 07/01/2012 - "Although allograft function was excellent immediately after surgery, massive proteinuria (35 g/d) appeared on post-transplantation day 5. After the allograft biopsy taken on post-transplantation day 6, he was treated with 12 cycles of plasma exchange, but the nephrotic-range proteinuria showed no remission. " 03/01/2004 - "Plasma exchange (PE) can reduce proteinuria and even induce complete remission of proteinuria. " 11/01/1999 - "Treatment with plasma exchange can lead to complete remission of proteinuria and relapsing patients may respond to repeated sessions. " 11/01/2006 - "To treat recurrent FSGS, plasma exchange was partially effective to reduce proteinuria. " 09/01/2004 - "To treat recurrent FGS, plasma exchange was partially effective, reducing the proteinuria but not stopping the progression of disease. "

Related Drugs and Biologics

1.	thymidine 5'-triphosphate (TTP)
2.	Immunoglobulins (Immunoglobulin)
3.	Adrenal Cortex Hormones (Corticosteroids)
4.	Intravenous Immunoglobulins (IVIG)
5.	Cyclophosphamide (Cytoxan)
6.	Steroids
7.	rituximab (Mabthera)
8.	Methylprednisolone
9.	Prednisone (Sone)
10.	Antibodies

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Plasmapheresis
3.	Renal Dialysis (Hemodialysis)
4.	Splenectomy
5.	Blood Component Removal (Apheresis)