Protein Glutamine gamma Glutamyltransferase 2

Calcium-dependent acyltransferase that catalyzes cross-linking of proteins at a GLUTAMINE in one chain with primary amine such as in LYSINE in another chain. In addition it can also accept monoamine substrates to catalyze post-translational modifications (e.g., protein serotonylation).

Also Known As:

Networked: 1663 relevant articles (45 outcomes, 140 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kim, Soo-Youl: 35 articles (04/2020 - 06/2002)
2.	Sollid, Ludvig M: 33 articles (01/2022 - 09/2002)
3.	Mäki, Markku: 29 articles (10/2021 - 03/2002)
4.	Kaukinen, Katri: 28 articles (05/2021 - 03/2002)
5.	Mehta, Kapil: 26 articles (01/2017 - 02/2002)
6.	Drukarch, Benjamin: 25 articles (01/2021 - 05/2008)
7.	Murray, Joseph A: 24 articles (01/2021 - 01/2005)
8.	Griffin, Martin: 22 articles (02/2021 - 08/2003)
9.	Khosla, Chaitan: 22 articles (01/2021 - 01/2002)
10.	Wilhelmus, Micha M M: 20 articles (01/2021 - 05/2008)

Related Diseases

1.	Celiac Disease (Celiac Sprue) 05/01/2000 - "These results proved that the human tissue transglutaminase-based ELISA represents a cost-effective strategy for identifying both symptomatic and atypical forms of celiac disease and could mean that intestinal biopsy need no longer be the gold standard for diagnosing this clinical condition. " 01/28/2018 - "Outcome measures The primary outcome measures used to indicate clinical, histological, and immunological recovery of celiac disease were clinical improvement at eight weeks and the proportion of patients with improved histology by at least one grade and who were tissue transglutaminase (tTg) seronegative at eight weeks. " 03/01/2023 - "Inhibition of Transglutaminase 2 as a Therapeutic Strategy in Celiac Disease-In Vitro Studies in Intestinal Cells and Duodenal Biopsies." 10/14/2021 - "A Trial of a Transglutaminase 2 Inhibitor in Celiac Disease. " 10/14/2021 - "A Trial of a Transglutaminase 2 Inhibitor in Celiac Disease."
2.	Neoplasms (Cancer) 01/01/2019 - "Previous studies have shown that transglutaminase 2 (TG2) induces epithelial to mesenchymal transition (EMT) in various tumors. " 01/01/2015 - "We found that SQAP directly bound to and inhibited transglutaminase 2. This study provides evidence that upregulation of tumor pVHL is a promising target, which can induce "angiogenic switch off" in HCC. " 12/01/2013 - "The role of tissue transglutaminase (tTG) in cancer development remains an important field of study. " 11/07/2006 - "Recent studies have suggested that the transamidation activity of TGase-II is necessary for the survival of cancer cells confronted with different stresses and cellular insults. " 11/01/2023 - "Transglutaminase 2 (TG2) is associated with mobilization, invasion, and chemoresistance of tumor cells. "
3.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 09/01/2023 - "The when, why and whom to biopsy of type 1 diabetes mellitus children with positive anti-tissue transglutaminase serology." 11/28/2021 - "Our aim was to assess the frequency of transitional elevation of anti-tissue transglutaminase in our type 1 diabetes patients. " 05/01/2001 - "Two hundred thirty-three children with type 1 diabetes were prospectively screened for CD using blind testing with the current 'gold standard', immunoglobulin A endomysium antibody (EmA), and the novel immunoglobulin A tissue transglutaminase (tTG) antibody. " 11/28/2021 - "Development of transitional elevation of anti-tissue transglutaminase antibodies in the diagnosis of type 1 diabetes is reported in some studies. " 10/14/2015 - "The objectives of this study were to establish the prevalence of positive antibodies to endomysium (EMA) and tissue transglutaminase (tTG) in children with type 1 diabetes living in Newfoundland and Labrador (NL), and to examine clinical features associated with positive antibodies. "
4.	Dermatitis Herpetiformis (Disease, Duhring's) 01/01/2003 - "Our results suggest that tissue transglutaminase can be recognised in the basal epidermal layer both of patients with dermatitis herpetiformis and controls. " 01/01/2001 - "Tissue transglutaminase antibody assessment in dermatitis herpetiformis." 01/01/2003 - "To study the distribution of tissue transglutaminase in the skin of dermatitis herpetiformis patients and controls, and to investigate whether the dermal IgA deposits, diagnostic for dermatitis herpetiformis, are related to tissue transglutaminase expression in the skin. " 03/01/2007 - "Tissue transglutaminase (tTG) is an autoantigen in coeliac disease and the related disorder, dermatitis herpetiformis. " 11/01/2005 - "Medical pearl: Using tissue transglutaminase antibodies to diagnose dermatitis herpetiformis."
5.	Huntington Disease (Huntington's Disease) 08/01/2000 - "Further, immunohistochemical studies have demonstrated that there is an increase in tissue transglutaminase reactivity in affected neurons in both Alzheimer's and Huntington's disease. " 01/01/2014 - "Genetic deletion of transglutaminase 2 does not rescue the phenotypic deficits observed in R6/2 and zQ175 mouse models of Huntington's disease." 09/01/2012 - "Tissue transglutaminase overexpression does not modify the disease phenotype of the R6/2 mouse model of Huntington's disease." 02/09/2012 - "Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease." 09/01/2010 - "The article by McConoughey et al in the current issue of EMBO Molecular Medicine examines the contribution of transglutaminase 2 (TG2) to Huntington's disease (HD) pathogenesis. "

Related Drugs and Biologics

1.	Antibodies
2.	Immunoglobulin A (IgA)
3.	Gliadin
4.	Autoantibodies
5.	Peptides (Polypeptides)
6.	Immunoglobulin G (IgG)
7.	Antigens
8.	Cystamine
9.	Proteins (Proteins, Gene)
10.	Glutens (Glutelin)

Related Therapies and Procedures

1.	Gluten-Free Diet
2.	Nephrectomy
3.	Therapeutics
4.	Drug Therapy (Chemotherapy)
5.	Liver Transplantation